Coupling of abiotic stresses and phytohormones for the production of lipids and high-value by-products by microalgae: A review

Zhao, Yongteng; Wang, Huiping; Han, Benyong; Yu, Xuya

doi:10.1016/j.biortech.2018.12.030

Cited by 189 publications

(47 citation statements)

References 97 publications

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“…It is now universally acknowledged that valuable product accumulation in microalgae cannot go without efficient carbon conversion among the main carbon sink 36 . Harnessing cultivation condition and environment is considered as a useful approach to produce the products purposefully.…”

Section: Discussionmentioning

confidence: 99%

Harnessing C/N balance of Chromochloris zofingiensis to overcome the potential conflict in microalgal production

et al. 2020

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Accumulation of high-value products in microalgae is not conducive with rapid cell growth, which is the potential conflict in microalgal production. Overcoming such conflict faces numerous challenges in comprehensively understanding cell behavior and metabolism. Here, we show a fully integrated interaction between cell behavior, carbon partitioning, carbon availability and path rate of central carbon metabolism, and have practically overcome the production conflict of Chromochloris zofingiensis. We demonstrate that elevated carbon availability and active path rate of precursors are determinants for product biosynthesis, and the former exhibits a superior potential. As protein content reaches a threshold value to confer survival advantages, carbon availability becomes the major limiting factor for product biosynthesis and cell reproduction. Based on integrated interaction, regulating the C/N balance by feeding carbon source under excess light increases content of high-value products without inhibiting cell growth. Our findings provide a new orientation to achieve great productivity improvements in microalgal production.

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Section: Discussionmentioning

confidence: 99%

Harnessing C/N balance of Chromochloris zofingiensis to overcome the potential conflict in microalgal production

et al. 2020

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“…The hormone and concentration range were chosen based on the preliminary investigations and previously reported studies [10,67]. All the hormones were obtained from Sigma Aldrich (USA).…”

Section: Methodsmentioning

confidence: 99%

Plant hormone induced enrichment of Chlorella sp. omega-3 fatty acids

Sivaramakrishnan

Incharoensakdi

2020

Biotechnol Biofuels

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Background: Omega-3 fatty acids have various health benefits in combating against neurological problems, cancers, cardiac problems and hypertriglyceridemia. The main dietary omega-3 fatty acids are obtained from marine fish. Due to the pollution of marine environment, recently microalgae are considered as the promising source for the omega-3 fatty acid production. However, the demand and high production cost associated with microalgal biomass make it necessary to implement novel strategies in improving the biomass and omega-3 fatty acids from microalgae. Results: Four plant hormones zeatin, indole acetic acid (IAA), gibberellic acid (GBA) and abscisic acid (ABA) were investigated for their effect on the production of biomass and lipid in isolated Chlorella sp. The cells showed an increase of the biomass and lipid content after treatments with the plant hormones where the highest stimulatory effect was observed in ABA-treated cells. On the other hand, IAA showed the highest stimulatory effect on the omega-3 fatty acids content, eicosapentaenoic acid (EPA) (23.25%) and docosahexaenoic acid (DHA) (26.06%). On the other hand, cells treated with ABA had highest lipid content suitable for the biodiesel applications. The determination of ROS markers, antioxidant enzymes, and fatty acid biosynthesis genes after plant hormones treatment helped elucidate the mechanism underlying the improvement in biomass, lipid content and omega-3 fatty acids. All four plant hormones upregulated the fatty acid biosynthesis genes, whereas IAA particularly increased omega-3-fatty acids as a result of the upregulation of omega-3 fatty acid desaturase. Conclusions: The contents of omega-3 fatty acids, the clinically important compounds, were considerably improved in IAA-treated cells. The highest lipid content obtained from ABA-treated biomass can be used for biodiesel application according to its biodiesel properties. The EPA and DHA enriched ethyl esters are an approved form of omega-3 fatty acids by US Food and Drug Administration (FDA) which can be utilized as the therapeutic treatment for the severe hypertriglyceridemia.

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“…The major reason for the decreased photosynthesis activity is the production of reactive oxygen species (ROS), which impairs the photosynthetic systems [130]. To solve this problem, a number of approaches have been suggested to reduce the oxidative stress caused by stressful conditions and hence increase lipid and biomass production [131,132].…”

Section: Inducer Additionmentioning

confidence: 99%

“…In an investigation, manipulating the iron, nitrate, and carbonate was reported to increase lipid and biomass production of three microalgae Chlorella sp., Scenedesmus sp., and Chlamydomonas sp. [133] Apart from bicarbonate addition, phytohormones also play an important role in metabolism regulation and growth of microalgae [86,131]. Phytohormone could increase the antioxidant system in the microalgae, which keeps a redox balance state under stressful conditions.…”

Section: Inducer Additionmentioning

confidence: 99%

Improving ‘Lipid Productivity’ in Microalgae by Bilateral Enhancement of Biomass and Lipid Contents: A Review

Shokravi

Ong

et al. 2020

Sustainability

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Microalgae have received widespread interest owing to their potential in biofuel production. However, economical microalgal biomass production is conditioned by enhancing the lipid accumulation without decreasing growth rate or by increasing both simultaneously. While extensive investigation has been performed on promoting the economic feasibility of microalgal-based biofuel production that aims to increase the productivity of microalgae species, only a handful of them deal with increasing lipid productivity (based on lipid contents and growth rate) in the feedstock production process. The purpose of this review is to provide an overview of the recent advances and novel approaches in promoting lipid productivity (depends on biomass and lipid contents) in feedstock production from strain selection to after-harvesting stages. The current study comprises two parts. In the first part, bilateral improving biomass/lipid production will be investigated in upstream measures, including strain selection, genetic engineering, and cultivation stages. In the second part, the enhancement of lipid productivity will be discussed in the downstream measure included in the harvesting and after-harvesting stages. An integrated approach involving the strategies for increasing lipid productivity in up- and down-stream measures can be a breakthrough approach that would promote the commercialization of market-driven microalgae-derived biofuel production.

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Coupling of abiotic stresses and phytohormones for the production of lipids and high-value by-products by microalgae: A review

Cited by 189 publications

References 97 publications

Harnessing C/N balance of Chromochloris zofingiensis to overcome the potential conflict in microalgal production

Harnessing C/N balance of Chromochloris zofingiensis to overcome the potential conflict in microalgal production

Plant hormone induced enrichment of Chlorella sp. omega-3 fatty acids

Improving ‘Lipid Productivity’ in Microalgae by Bilateral Enhancement of Biomass and Lipid Contents: A Review

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