Coupling electrochemistry to capillary electrophoresis-mass spectrometry

Cindric, Marija; Matysik, Frank‐Michael

doi:10.1016/j.trac.2015.02.019

Cited by 17 publications

(8 citation statements)

References 24 publications

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“…Other detection schemes are less suitable and much less often utilized for peptide detection in CE and CEC than the above UV‐absorption, fluorescence, and MS detectors. For that reason only some recent reviews are cited here, which are dealing with general developments and applications of these detectors in separation methods, such as contact or contacless capacitively coupled conductivity detection (C 4 D) , electrochemical , chemiluminiscence , electrochemiluminiscence , infrared spectroscopy, and NMR . In these reviews, few applications of these detectors for CE and CEC separations of peptides as model analytes can be found.…”

Section: Detectionmentioning

confidence: 99%

Recent developments in capillary and microchip electroseparations of peptides (2015–mid 2017)

Kašička

2017

Electrophoresis

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The review brings a comprehensive overview of recent developments and applications of high performance capillary and microchip electroseparation methods (zone electrophoresis, isotachophoresis, isoelectric focusing, affinity electrophoresis, electrokinetic chromatography, and electrochromatography) to analysis, microscale isolation, purification, and physicochemical and biochemical characterization of peptides in the years 2015, 2016, and ca. up to the middle of 2017. Advances in the investigation of electromigration properties of peptides and in the methodology of their analysis (sample preseparation, preconcentration and derivatization, adsorption suppression and EOF control, and detection) are described. New developments in particular CE and CEC methods are presented and several types of their applications to peptide analysis are reported: qualitative and quantitative analysis, determination in complex (bio)matrices, monitoring of chemical and enzymatical reactions and physical changes, amino acid, sequence and chiral analysis, and peptide mapping of proteins. Some micropreparative peptide separations are shown and capabilities of CE and CEC methods to provide important physicochemical characteristics of peptides are demonstrated.

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Section: Detectionmentioning

confidence: 99%

Recent developments in capillary and microchip electroseparations of peptides (2015–mid 2017)

Kašička

2017

Electrophoresis

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“…Indirect electrochemical detection with serial dual‐electrode detector based on electrogeneration of bromine on the first electrode and on the detection of remaining bromine (nonconsumed by the reaction with analytes in the on‐line end‐column flow‐through cell) by the downstream electrode has been applied to analysis of GSH and GSH disulfide (GSSG) in commercial GSH supplement with LODs 0.16 μM for GSH and 0.14 μM for GSSG . For the other detection modes only some recent reviews are cited, which are dealing with general developments and applications of these detectors, such as electrochemical , contactless conductivity , chemiluminescence , electrochemiluminescence , and NMR . In these reviews few applications of these detectors for CE separation of peptides as model analytes can be found.…”

Section: Detectionmentioning

confidence: 99%

Recent developments in capillary and microchip electroseparations of peptides (2013–middle 2015)

Kašička

2015

Electrophoresis

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The review brings a comprehensive survey of recent developments and applications of high performance capillary and microchip electroseparation methods (zone electrophoresis, isotachophoresis, isoelectric focusing, affinity electrophoresis, electrokinetic chromatography, and electrochromatography) to analysis, micropreparation, purification, and physicochemical and biochemical characterization of peptides in the years 2013, 2014, and ca. up to the middle of 2015. Advances in the investigation of electromigration properties of peptides, in the methodology of their analysis, including sample preseparation, preconcentration and derivatization, adsorption suppression and EOF control, as well as in detection of peptides, are described. New developments in particular CE and CEC modes are presented and several types of their applications to peptide analysis are reported: conventional qualitative and quantitative analysis, determination in complex (bio)matrices, monitoring of chemical and enzymatical reactions and physical changes, amino acid, sequence, and chiral analysis, and peptide mapping of proteins. Some micropreparative peptide separations are shown and capabilities of CE and CEC techniques to provide important physicochemical characteristics of peptides are demonstrated.

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“…[5] Some excellent techniques were previously developed to enable product determination with improved temporal/ potential resolution. [8] Koper and co-workers combined cyclic voltammetry with online fraction collection at the electrode vicinity and post-analyzed the collected samples with chromatography to achieve temporal resolution in the order of about one minute. [6] The analysis of liquids in real time is in general possible with electrospray ionization (ESI) or atmospheric pressure chem-ical ionization (APCI), but their use in electrochemistry is often complicated because of ion suppression by non-volatile salts that are used as electrolytes.…”

mentioning

confidence: 99%

Electrochemical Real‐Time Mass Spectrometry (EC‐RTMS): Monitoring Electrochemical Reaction Products in Real Time

et al. 2019

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Coupling electrochemistry to capillary electrophoresis-mass spectrometry

Cited by 17 publications

References 24 publications

Recent developments in capillary and microchip electroseparations of peptides (2015–mid 2017)

Recent developments in capillary and microchip electroseparations of peptides (2015–mid 2017)

Recent developments in capillary and microchip electroseparations of peptides (2013–middle 2015)

Electrochemical Real‐Time Mass Spectrometry (EC‐RTMS): Monitoring Electrochemical Reaction Products in Real Time

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