Coupling between somatosensory evoked potentials and hemodynamic response in the rat

Franceschini, Maria Angela; Nissilä, Ilkka; Wu, Wei‐Cheng; Diamond, Solomon; Bonmassar, Giorgio; Boas, David A.

doi:10.1016/j.neuroimage.2008.02.061

Cited by 70 publications

(77 citation statements)

References 71 publications

(107 reference statements)

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“…For anesthesia-free neural recording, telemetry systems and linear arrays of microelectrodes have been introduced in behaving small animals (Schregardus et al, 2006) and humans (Keller et al, 2009). Electroencephalogram and magnetoencephalogram also provide less-invasive neural measurements and allow concurrent recording with cortical hemodynamics in anesthetized animals (Franceschini et al, 2008) and in conscious humans (Rosengarten and Kaps, 2010;Ou et al, 2009).…”

Section: Why Is Anesthesia Needed?mentioning

confidence: 99%

Anesthesia and the Quantitative Evaluation of Neurovascular Coupling

Masamoto

Kanno²

2012

J Cereb Blood Flow Metab

237

187

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Anesthesia has broad actions that include changing neuronal excitability, vascular reactivity, and other baseline physiologies and eventually modifies the neurovascular coupling relationship. Here, we review the effects of anesthesia on the spatial propagation, temporal dynamics, and quantitative relationship between the neural and vascular responses to cortical stimulation. Previous studies have shown that the onset latency of evoked cerebral blood flow (CBF) changes is relatively consistent across anesthesia conditions compared with variations in the time-to-peak. This finding indicates that the mechanism of vasodilation onset is less dependent on anesthesia interference, while vasodilation dynamics are subject to this interference. The quantitative coupling relationship is largely influenced by the type and dosage of anesthesia, including the actions on neural processing, vasoactive signal transmission, and vascular reactivity. The effects of anesthesia on the spatial gap between the neural and vascular response regions are not fully understood and require further attention to elucidate the mechanism of vascular control of CBF supply to the underlying focal and surrounding neural activity. The in-depth understanding of the anesthesia actions on neurovascular elements allows for better decision-making regarding the anesthetics used in specific models for neurovascular experiments and may also help elucidate the signal source issues in hemodynamic-based neuroimaging techniques.

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Section: Why Is Anesthesia Needed?mentioning

confidence: 99%

Anesthesia and the Quantitative Evaluation of Neurovascular Coupling

Masamoto

Kanno²

2012

J Cereb Blood Flow Metab

237

187

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“…Increases in synaptic activity drive the vascular response [1][2][3][4], which involves coordinated signalling among cells of the neurovascular unit. The initial trigger of the haemodynamic signature is the change in the activity of the neural network processing the incoming stimulus [5][6][7], although signalling in astrocytes [8][9][10], pericytes [11], smooth muscle [12] and endothelial [13] cells may contribute to the changes in vessel diameter.…”

Section: Introductionmentioning

confidence: 99%

Neuronal networks and mediators of cortical neurovascular coupling responses in normal and altered brain states

Lecrux

Hamel

2016

Phil. Trans. R. Soc. B

101

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One contribution of 15 to a Theo Murphy meeting issue 'Interpreting BOLD: a dialogue between cognitive and cellular neuroscience'. Brain imaging techniques that use vascular signals to map changes in neuronal activity, such as blood oxygenation level-dependent functional magnetic resonance imaging, rely on the spatial and temporal coupling between changes in neurophysiology and haemodynamics, known as 'neurovascular coupling (NVC)'. Accordingly, NVC responses, mapped by changes in brain haemodynamics, have been validated for different stimuli under physiological conditions. In the cerebral cortex, the networks of excitatory pyramidal cells and inhibitory interneurons generating the changes in neural activity and the key mediators that signal to the vascular unit have been identified for some incoming afferent pathways. The neural circuits recruited by whisker glutamatergic-, basal forebrain cholinergic-or locus coeruleus noradrenergic pathway stimulation were found to be highly specific and discriminative, particularly when comparing the two modulatory systems to the sensory response. However, it is largely unknown whether or not NVC is still reliable when brain states are altered or in disease conditions. This lack of knowledge is surprising since brain imaging is broadly used in humans and, ultimately, in conditions that deviate from baseline brain function. Using the whisker-to-barrel pathway as a model of NVC, we can interrogate the reliability of NVC under enhanced cholinergic or noradrenergic modulation of cortical circuits that alters brain states.This article is part of the themed issue 'Interpreting BOLD: a dialogue between cognitive and cellular neuroscience'.

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“…Simultaneously acquired EEG can account for more of the variation in hemodynamics measured with NIRS than a task paradigm alone. 1 This suggests that the covariance in task related responses in simultaneously acquired EEG and NIRS contain additional information about neurovascular function or brain activity that cannot be observed when using these systems sequentially. It has also been suggested that hemodynamic factors can modify neural activity through the so-called hemo-neural hypothesis.…”

Section: Introductionmentioning

confidence: 99%

Compliant head probe for positioning electroencephalography electrodes and near-infrared spectroscopy optodes

Giacometti

Diamond

2013

J. Biomed. Opt

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Abstract. A noninvasive head probe that combines near-infrared spectroscopy (NIRS) and electroencephalography (EEG) for simultaneous measurement of neural dynamics and hemodynamics in the brain is presented. It is composed of a compliant expandable mechanism that accommodates a wide range of head size variation and an elastomeric web that maintains uniform sensor contact pressure on the scalp as the mechanism expands and contracts. The design is intended to help maximize optical and electrical coupling and to maintain stability during head movement. Positioning electrodes at the inion, nasion, central, and preauricular fiducial locations mechanically shapes the probe to place 64 NIRS optodes and 65 EEG electrodes following the 10-5 scalp coordinates. The placement accuracy, precision, and scalp pressure uniformity of the sensors are evaluated. A root-mean-squared (RMS) positional precision of 0.89 AE 0.23 mm, percent arc subdivision RMS accuracy of 0.19 AE 0.15%, and mean normal force on the scalp of 2.28 AE 0.88 N at 5 mm displacement were found. Geometric measurements indicate that the probe will accommodate the full range of adult head sizes. The placement accuracy, precision, and uniformity of sensor contact pressure of the proposed head probe are important determinants of data quality in noninvasive brain monitoring with simultaneous NIRS-EEG.

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Coupling between somatosensory evoked potentials and hemodynamic response in the rat

Cited by 70 publications

References 71 publications

Anesthesia and the Quantitative Evaluation of Neurovascular Coupling

Anesthesia and the Quantitative Evaluation of Neurovascular Coupling

Neuronal networks and mediators of cortical neurovascular coupling responses in normal and altered brain states

Compliant head probe for positioning electroencephalography electrodes and near-infrared spectroscopy optodes

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