Country of birth modifies the association of fatty liver index with insulin action in Middle Eastern immigrants to Sweden

Bennet, Louise; Groop, Leif; Franks, Paul W.

doi:10.1016/j.diabres.2015.07.011

Cited by 10 publications

(4 citation statements)

References 28 publications

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“…On the other hand, a study in adults in Sweden demonstrated NAFLD prevalence was higher in individuals born in Middle East countries compared to individuals born in Sweden. 35 The null association of Nordic background with NAFLD in this study may be due to the categorization of ethnic background or lack of statistical power to detect the difference. Moreover, we cannot exclude that ethnicity and/or genetic components may differ in cases which are more prone to develop NAFLD.…”

Section: Some Studies In Children and Adolescents With Obesity Havementioning

confidence: 79%

Risk and protective factors of non‐alcoholic fatty liver disease in paediatric obesity: A nationwide nested case–control study

2021

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Not all children with obesity carry a similar risk of non-alcoholic fatty liver disease (NAFLD). We investigated the effect of obesity severity, metabolic risk parameters, and obesity treatment outcome on later risk of NAFLD in paediatric obesity. We conducted a nested case-control study of children and adolescents enrolled in the Swedish Childhood Obesity Treatment Register (BORIS) (2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016). NAFLD was ascertained from the National Patient Register. Five controls per case were matched by sex and age at index date and at the obesity treatment initiation. Seventy-six pairs (n cases = 76, n controls = 241) were included in the analysis (29% females, mean age at obesity treatment initiation was 10.8 ± 3.07 years). Mean age of NAFLD diagnosis was 14.2 ± 3.07 years. The risk for NAFLD increased with severe obesity (odds

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Section: Some Studies In Children and Adolescents With Obesity Havementioning

confidence: 79%

Risk and protective factors of non‐alcoholic fatty liver disease in paediatric obesity: A nationwide nested case–control study

2021

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“…IMCL was significantly associated with IR in European Americans, while in African Americans, IMCL varied independent of IR ( 96 ). Another study reported a stronger association between IHCL and IR in individuals born in Iraq as compared to individuals born in Sweden ( 97 ). Moreover, it is well-established that South-Asians are more likely to develop IR and have more ectopic fat (both IHCL and IMCL) when compared to BMI-matched Caucasians ( 98 – 101 ).…”

Section: Ectopic Fat and Insulin Resistance: Pathophysiology And Intementioning

confidence: 97%

Ectopic Fat Accumulation in Distinct Insulin Resistant Phenotypes; Targets for Personalized Nutritional Interventions

et al. 2018

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Cardiometabolic diseases are one of the leading causes for disability and mortality in the Western world. The prevalence of these chronic diseases is expected to rise even further in the next decades. Insulin resistance (IR) and related metabolic disturbances are linked to ectopic fat deposition, which is the storage of excess lipids in metabolic organs such as liver and muscle. Notably, a vicious circle exists between IR and ectopic fat, together increasing the risk for the development of cardiometabolic diseases. Nutrition is a key-determining factor for both IR and ectopic fat deposition. The macronutrient composition of the diet may impact metabolic processes related to ectopic fat accumulation and IR. Interestingly, however, the metabolic phenotype of an individual may determine the response to a certain diet. Therefore, population-based nutritional interventions may not always lead to the most optimal (cardiometabolic) outcomes at the individual level, and differences in the metabolic phenotype may underlie conflicting findings related to IR and ectopic fat in dietary intervention studies. Detailed metabolic phenotyping will help to better understand the complex relationship between diet and metabolic regulation, and to optimize intervention outcomes. A subgroup-based approach that integrates, among others, tissue-specific IR, cardiometabolic parameters, anthropometrics, gut microbiota, age, sex, ethnicity, and psychological factors may thereby increase the efficacy of dietary interventions. Nevertheless, the implementation of more personalized nutrition may be complex, costly, and time consuming. Future studies are urgently warranted to obtain insight into a more personalized approach to nutritional interventions, taking into account the metabolic phenotype to ultimately improve insulin sensitivity and reduce the risk for cardiometabolic diseases.

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“…Researchers have clarified the associations between FLI and the risk of diabetes [ 39 , 40 ]. Several previous studies mentioned that high FLI increases the risk of developing diabetes mellitus [ 41 – 43 ]. For instance, FLI > 60 is independently related to the occurrence of T2DM after three years of follow-up in the Spanish PREDAPS study regardless of sex, age, or education level [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

The association between fatty liver index and onset of diabetes: secondary analysis of a population-based cohort study

Zhu

et al. 2023

BMC Public Health

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Background According to research, the fatty liver index (FLI) is associated with diabetes. However, few studies have been conducted to investigate the relationship between FLI and diabetes risk from various perspectives. This study comprehensively investigated the relationship between FLI and incident diabetes in a large Japanese population. Methods This retrospective cohort study included 14,280 participants from Murakami Memorial Hospital in Japan from 2004 to 2015. The independent and dependent variables are FLI and risk of type 2 diabetes mellitus (T2DM), respectively. To examine the link between FLI and incident T2DM, Cox proportional-hazards regression was employed. In addition, we performed a number of sensitivity studies to guarantee the validity of the results. Moreover, we conducted subgroup analyses. Results After adjusting covariates, the results showed that FLI was positively associated with the risk of T2DM (HR = 1.019, 95%CI: 1.012, 1.025). Additionally, the sensitivity analysis showed how reliable the outcomes were. And a stronger association between FLI and incident T2DM was observed in the regular exercisers (HR = 1.036, 95%CI: 1.019–1.053, P < 0.0001) and the population without ethanol consumption (HR = 1.028, 95%CI: 1.017–1.039, P < 0.0001). Besides, receiver operating characteristic (ROC) curve analysis showed that FLI was better than waist circumference, triglycerides, body mass index, and gamma-glutamyl transferase in predicting incident T2DM. Conclusion FLI is positively associated with incident T2DM.

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Country of birth modifies the association of fatty liver index with insulin action in Middle Eastern immigrants to Sweden

Cited by 10 publications

References 28 publications

Risk and protective factors of non‐alcoholic fatty liver disease in paediatric obesity: A nationwide nested case–control study

Risk and protective factors of non‐alcoholic fatty liver disease in paediatric obesity: A nationwide nested case–control study

Ectopic Fat Accumulation in Distinct Insulin Resistant Phenotypes; Targets for Personalized Nutritional Interventions

The association between fatty liver index and onset of diabetes: secondary analysis of a population-based cohort study

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