Counteractive functions are encrypted in the residues of CD154

Bandyopadhyay, Syamdas; Chandel, Himanshu Singh; Singh, Shailza; Roy, Somenath; Krishnasastry, M.V.; Saha, Bhaskar

doi:10.1016/j.humimm.2015.09.019

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…[4][5][6] . The information presented above attests to the fact that CD40 shows pleiotropism in its functions and can be considered as a double-edged sword in which, on one hand, the ligation of CD40 with CD154 is crucial for the execution of several important immunological functions that maintain immune homeostasis such as anti-leishmanial functions [7][8][9] , on the other hand, successful CD40-CD154 engagement drives several pathological conditions in humans promoting diseases. This leads us to think about the feasibility of CD40 signaling being manipulated to evoke agonistic or antagonistic effector functions.…”

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confidence: 86%

“…Because amino acid residues are crucial for the effective interaction between CD40 and CD154, attempts have been made to perform point mutations on the ligand to alter the final outcome. Five residues were targeted for sitedirected mutagenesis: S128, E129, K143, G144, and Y145 8 . Substitution of S128 to V [S128V] shows a lower value of K D indicating reduced affinity of the interaction with CD40 as compared to the wild type.…”

Section: Mutational Manipulation Of Cd154mentioning

confidence: 99%

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Advances in the CD40-mediated Manipulation Strategies

Bandyopadhyay

2023

Biosci., Biotech. Res. Asia

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Immune homeostasis is crucial in a normal physiological, diseased, or pathogenic state and is mediated by numerous biological molecules. Certain pairs of costimulatory molecules, such as CD40-CD154 play major roles in many different situations. The functions of CD40-CD154 are pivotal for the maintenance of the immune system, cancer prevention, promotion of autoimmune disorders, and fighting against many pathogens. Since the discovery of CD40-CD154, numerous approaches have been taken to dissect this pathway favoring the interest of the host. Ranging from generating small peptides to mutated CD40L to agonistic or antagonistic antibodies have been tested in different models with varying levels of success. This review focuses on the various strategies that have been employed to manipulate CD40-CD154 dyad. Comprehensive knowledge of the understanding of different manipulation strategies of the CD40-CD154 pathway could be important for therapeutic purposes.

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mentioning

confidence: 86%

Section: Mutational Manipulation Of Cd154mentioning

confidence: 99%