Abstract:Immune homeostasis is crucial in a normal physiological, diseased, or pathogenic state and is mediated by numerous biological molecules. Certain pairs of costimulatory molecules, such as CD40-CD154 play major roles in many different situations. The functions of CD40-CD154 are pivotal for the maintenance of the immune system, cancer prevention, promotion of autoimmune disorders, and fighting against many pathogens. Since the discovery of CD40-CD154, numerous approaches have been taken to dissect this pathway fa… Show more
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