“…Also prolongation of L-DOPA activity by 7-NI would be considered to be a beneficial effect due to avoidance of pulsatile stimulation of striatal postsynaptic DA receptors, that is one of the main cause of L-DOPA-induced dyskinesia (Huot et al, 2013). Consistently with our results, Del- Bel et al (2014) reported that 7-NI, decreasing DA turnover, simultaneously reduced L-DOPA induced DA dyskinesia. However, L-NAME that was also described to reduce L-DOPA-induced dyskinesia (Padovan-Neto et al, 2009;Takuma et al, 2012) did not affect DA turnover in our study.…”