Coumarins from <i>Seseli hartvigii</i>

Zhang, Lin; Tosun, Alev; Baba, M.; Okada, Yoshihito; Li-jun, WU; Okuyama, Torn

doi:10.1177/1934578x1000500717

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…Besides, the genus Seseli is known to be rich in coumarins, a number of which are recognized for their medicinal properties [12][13][14][15]. Attempts were also made to explore the detailed underlying mechanism of coumarins isolated from Seseli species, as active pharmacological agents.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Biological and Chemical Evaluation of Two Seseli Species (S. gummiferum and S. transcaucasicum)

et al. 2021

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Seseli L. is one of the largest genera of the Apiaceae family widely known for their traditional uses as herbal remedies. In the present study, the methanolic and water extracts of two Seseli species, S. gummiferum and S. transcaucasicum were evaluated for their bioactive contents and biological activities. The total phenolic and flavonoid contents in the extracts ranged from 19.09 to 24.33 mg GAE/g and from 0.45 to10.09 mg RE/g, respectively. Moreover, while narcissin was detected as the most abundant component in the methanolic extract of S. transcaucasicum (261.40 µg/g), chlorogenic acid was identified as the major component in all the other extracts, although a high amount was also present in the methanolic S. transcaucasicum extract (107.48–243.12 µg/g). The total antioxidant capacity was also determined by the phosphomolybdenum assay (0.66–1.18 mM TE/g). Other antioxidant assays such as the radical scavenging assays (DPPH: 5.51–11.45 mg TE/g; ABTS: 43.46–51.91 mg TE/g), reducing assays (CUPRAC: 41.67–53.20 mg TE/g; FRAP: 31.26–34.14 mg TE/g), as well as the metal chelating activity assay (14.38–38.57 mg EDTAE/g) were conducted. All the extracts showed inhibitory potential against the enzyme’s amylase (0.12–0.78 mM ACAE/g), acetyl- and butyryl-cholinesterase (0.15–9.71 mg GALAE/g), while only the methanolic extracts acted as inhibitors of tyrosinase (107.15 and 109.37 mg KAE/g) and only the water extract of S. gummiferum displayed anti-glucosidase activity (0.13 mM ACAE/g). Interestingly, the methanolic extracts of both Seseli species showed lower cytotoxicity towards HaCaT cells (IC50: >500 µg/mL), compared to the water extracts (IC50: 267.8 and 321.41 µg/mL). Besides, only the methanolic extracts showed a slight wound healing effect (28.21 and 31.23%). All extracts showed antibacterial action against Staphylococcus lugdunensis (minimum inhibitory and bactericidal concentrations: 0.025–2 mg/mL). S. gummiferum methanolic extract, which exhibited the highest antibacterial potency was found to inhibit adhesion and invasion of S. lugdunensis to HaCaT cells as well. Taken together, this study demonstrated the two Seseli species to harbour interesting bioactive components, in particular polyphenolics and to exhibit several biological properties that could be further investigated for their potential exploitation as healing agents as supported by various traditional medicinal uses.

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Section: Introductionmentioning

confidence: 99%

Comprehensive Biological and Chemical Evaluation of Two Seseli Species (S. gummiferum and S. transcaucasicum)

et al. 2021

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“…In Turkey, there are limited studies on Seseli species based on the coumarins Tosun, 2006;Tosun et al, 2006a, Zhang et al, 2010Shehzad et al, 2013) and the essential oils (Baser et al, 2000;Kaya et al, 2003;2006b;2006c). Previously, antimicrobial (Tosun et al, 2004), anti-inflammatory and antinociceptive (Küpeli et al, 2005;Tosun et al, 2009;Chun et al, 2016) effects have been performed on Turkish Seseli species.…”

Section: Introductionmentioning

confidence: 99%

EVALUATION of ANTIOXIDANT POTENCY on SESELI L. SPECIES (APIACEAE)

Önder¹,

Çınar²,

Sarıaltın³

et al. 2019

tjps

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“…On the basis of previously conducted chemical studies, it is known that Seseli species are a source of coumarins, sesquiterpenes, and phenyl propanoides. 5-9 Previous analyses of the essential oils from various Seseli species demonstrated that the main components are quite different from species to species: sabinene, α-pinene, and β-phellandrene in S. globiferum aerial parts 10 ; α-pinene in S. rigidum Waldst. & Kit.…”

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confidence: 99%

Chemical Compositions of the Essential Oils and Headspace Volatiles of Seseli peucedanoides Plant Parts

Petrović

Stamenković

Jovanović

et al. 2019

Natural Product Communications

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The chemical compositions of the essential oils of Seseli peucedanoides (M.Bieb.) Koso-Pol. inflorescences and leaves, isolated by hydrodistillation, and headspace volatiles, obtained by the static headspace method, were analyzed in detail by gas chromatography (GC) and GC/mass spectrometry (MS). In total, 74 constituents were identified, representing more than 98% of the observed GC peaks. The number of identified essential oil components obtained from the inflorescences was 63 while for the leaf essential oil it was 46. A much smaller number of compounds, 26 for inflorescences and 21 for leaves, were detected in the headspace samples. In both essential oils the most abundant compounds were the same, (E)-caryophyllene and germacrene D, only in different proportions. The main components in the headspace specimens were α-pinene and (E)-β-ocimene with (E)-caryophyllene and (Z)-3-hexen-1-ol also determined in significant percentages. The major class of compounds identified in the investigated essential oils was hydrocarbon sesquiterpenes with a share of over 80%, while the most dominant class of the headspace volatiles was hydrocarbon monoterpenes, which contribute slightly less than 80% of the total.

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Coumarins from Seseli hartvigii

Cited by 4 publications

References 12 publications

Comprehensive Biological and Chemical Evaluation of Two Seseli Species (S. gummiferum and S. transcaucasicum)

Comprehensive Biological and Chemical Evaluation of Two Seseli Species (S. gummiferum and S. transcaucasicum)

EVALUATION of ANTIOXIDANT POTENCY on SESELI L. SPECIES (APIACEAE)

Chemical Compositions of the Essential Oils and Headspace Volatiles of Seseli peucedanoides Plant Parts

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