Coumarins from <i>Murraya exotica</i> Collected in Egypt

Negi, Naoko; Abou-Dough, Ahmad Muhamad; Kurosawa, Masumi; Kitaji, Yukako; Saito, Keiko; Ochi, Asae; Ushijima, Kaori; Kusakabe, Eri; Kitaguchi, Yoshimi; Jinguji, Yu; Teshima, Naoko; Ju‐ichi, Motoharu; Ito, Chihiro

doi:10.1177/1934578x1501000420

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…Of these, 72 compounds belong to the polymethoxylated flavonoid family, 90 were isolated from M. paniculata , and 24 were isolated from M. exotica , confirming that flavonoids were isolated mainly from M. paniculata ( Lu et al, 2021a ). Twenty-one compounds were isolated from M. paniculata and M. exotica ( Negi et al, 2015 ; Sangkaew et al, 2020 ). Depending on their structure, flavonoids can be divided into six types: flavones, flavonols, flavanones, flavan-3-ols, chalcones, and isoflavones; of these, flavones are the primary structures of flavonoids in MFC ( Figure 3 ).…”

Section: Phytochemistrymentioning

confidence: 99%

A comprehensive review of the botany, phytochemistry, pharmacology, and toxicology of Murrayae Folium et Cacumen

Qi,

Wang,

Wang

et al. 2024

Front. Pharmacol.

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Ethnopharmacological relevance: Murrayae Folium et Cacumen (MFC) is a plant considered to be a traditional Chinese medicine with culinary value as well. The dry leaves and twigs of Murraya paniculata and M. exotica are used to treat stomach aches, rheumatism, toothaches, swelling, and insect and snake bites. They are also used to prepare spicy chicken dishes.Aim of the review: This review comprehensively summarizes the available information on the botanical characterization, phytochemistry, pharmacological activities, pharmacodynamics, pharmacokinetics, and toxicity of MFC.Methods: Relevant scientific literature up to August 2023 was included in the study. Chinese and English studies on MFC were collected from databases, including PubMed, Elsevier, Web of Science, Springer, Science Direct, Wiley, ACS, and CNKI (Chinese). Doctoral and Master’s dissertations were also included.Results: In total, 720 compounds have been identified and reported in the literature, including flavonoids, coumarins, alkaloids, sterols, phenylpropenols, organic acids, spirocyclopentenones, and volatile oils. Flavonoids and coumarins are the two most important bioactive compounds responsible for these pharmacological activities. MFC has anti-inflammatory, anti-bacterial, anti-microbial, anti-diabetic, anti-tumor, anti-oxidant, anti-depressant, potential anti-Alzheimer’s disease, chondroprotective, and analgesic properties. The pharmacological effects include interrupting the STAT3/NF-κB/COX-2 and EGFR signaling pathways, downregulating EpCAM expression, inhibiting NF-κB and ERK signals, inhibiting the EP/cAMP/PKA signaling pathway and miR-29a/Wnt/β-catenin signaling activity, and upregulating Foxo3a expression.Conclusion: This review demonstrates that the chemical constituents, pharmacological activities, pharmacodynamics, pharmacokinetics, and toxicity of MFC support its use in traditional Chinese botanical medicines. MFC contains a wide range of chemical compounds. Flavonoids and coumarins promote strong pharmacological activity and, are low-toxicity natural phytomedicines that are widely used in medicine, food, ornamentation, and cosmetics, making MFC a promising compound for development and use in the treatment of several medical conditions.

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Section: Phytochemistrymentioning

confidence: 99%

A comprehensive review of the botany, phytochemistry, pharmacology, and toxicology of Murrayae Folium et Cacumen

Qi,

Wang,

Wang

et al. 2024

Front. Pharmacol.

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Coumarins from African medicinal plants: A review of their cytotoxic potential towards drug sensitive and multidrug-resistant cancer cell lines

Nchiozem-Ngnitedem,

Dongmo,

Tsamo

et al. 2024

Advances in Botanical Research

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Biological Importance and Pharmacological Activities of Meranzin and Meranzin Hydrate Against Human Disorders

Patel

2022

CCCHEM

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Background: Herbal plant based products and their derived phytochemicals have been used in the complementary and alternative system of medicine for the treatment of human disorders. Vegetables, fruits, seeds, nuts, coffee, tea, and wine contain significant amounts of coumarin class phytochemicals. Coumarin is found to be present in cassia leaf oil, cinnamon bark oil, lavender oil and in microorganism derived drugs. Methods: Scientific databases such as Google, Google Scholar, Science Direct, Scopus, and PubMed have been searched to collect the scientific information of meranzin and meranzin hydrate in the present work in order to know the medicinal importance and pharmacological activities in the medicine. Pharmacological activity data of meranzin and meranzin hydrates has been thoroughly studied from these scientific databases and analyzed in the present work to know their biological potential against human disorders. Analytical data of meranzin and meranzin hydrates have been also collected and analyzed in the present work to know the importance of analytical techniques for the standardization of plant material. Results: Scientific data analysis revealed the biological potential of meranzin and meranzin hydrates against human health complications. Meranzin were found to be present in the Fructus aurantii, Triphasia trifolia, Cnidium monnieri and Murraya exotica. Scientific data analysis revealed the biological potential of meranzin and meranzin hydrates in the medicine due to its anti-depressant, anti-fibrotic, anti-proliferative, and anti-atherosclerosis, anti-bacterial activities. Further scientific data analysis revealed the biological effectiveness of meranzin and meranzin hydrates on neuroinflammation, intestinal motility and various forms of enzymes. Pharmacokinetic parameters for meranzin and meranzin hydrates have been also investigated in the present work. Chromatography techniques used for the analysis have been also summarized and discussed in the present work to know the importance of isolation, separation, and quantification of meranzin and meranzin hydrates. Conclusion: Present study will be supportive to the scientist for the development of effective medicine from meranzin and meranzin hydrates against various form of human health complications.

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Coumarins from Murraya exotica Collected in Egypt

Cited by 3 publications

References 26 publications

A comprehensive review of the botany, phytochemistry, pharmacology, and toxicology of Murrayae Folium et Cacumen

A comprehensive review of the botany, phytochemistry, pharmacology, and toxicology of Murrayae Folium et Cacumen

Coumarins from African medicinal plants: A review of their cytotoxic potential towards drug sensitive and multidrug-resistant cancer cell lines

Biological Importance and Pharmacological Activities of Meranzin and Meranzin Hydrate Against Human Disorders

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