Coumarins from Cedrelopsis grevei (Ptaeroxylaceae)

Mulholland, Dulcie A.; Kotsos, Maria; Mahomed, Hamdani; Koorbanally, Neil A.; Randrianarivelojosia, Milijaona; Ufford, Linda Quarles van; Berg, A. J. J. van den

doi:10.1016/s0031-9422(02)00440-5

Cited by 19 publications

(15 citation statements)

References 9 publications

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“…In accordance with data reported in the literature (21,27), fractionation studies of CG lead to the isolation of coumarins, triterpenes, chromones, and polyphenols (O. Rakotoarison; unpublished data). Five coumarins have been isolated: norbraylin, methyl-O-cedrelopsin, cedrecoumarin A, scoparone, and braylin, and they are among the constituents responsible for the vasorelaxing activity observed for the crude extract (24).…”

Section: Discussionsupporting

confidence: 80%

“…The endothelium-dependent component of the response was completely prevented by NOS and guanylyl cyclase inhibitor, suggesting the involvement of the NO pathway (O. Rakotoarison; unpublished observations). It should be noted that some of chemical constituents of CG have been described as antihypertensive and vasodilator [for scoparone (24,28)] or as antioxidant (21). In addition, CG contains flavonoids like quercertin, which is known to have many beneficial effects as an antihypertensive and antioxidant (12).…”

Section: Discussionmentioning

confidence: 99%

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Cedrelopsis grevei induced hypotension and improved endothelial vasodilatation through an increase of Cu/Zn SOD protein expression

Ranaivo¹,

Rakotoarison²,

Tesse³

et al. 2004

American Journal of Physiology-Heart and Circulatory Physiology

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. Cedrelopsis grevei induced hypotension and improved endothelial vasodilatation through an increase of Cu/Zn SOD protein expression. Am J Physiol Heart Circ Physiol 286: H775-H781, 2004. First published November 6, 2003 10.1152/ajpheart.00584.2003.-This study was designed to investigate the cardiovascular consequences of oral administration of Cedrelopsis grevei (CG) in normotensive rats. Experiments were designed to investigate hemodynamic parameters in vivo as well as the consequences of CG treatment on the vasoconstriction response to norepinephrine and the vasorelaxant response to ACh ex vivo in isolated aortas and small mesenteric arteries (SMA). Treatment of male Wistar rats with 80 mg/kg CG for 4 wk induced a progressive decrease in systolic blood pressure. In the aorta, CG did not significantly alter the response to norepinephrine despite the participation of extraendothelial nitric oxide (NO)-induced hyporeactivity. In the SMA, contraction to norepinephrine was not modified by CG treatment even though it enhanced the participation of endothelial NO. Endothelium-dependent relaxation to ACh was increased in both the aorta and SMA from CG-treated rats. In the aorta from CG-treated rats, the mechanism involved superoxide dismutase (SOD)-and catalase-sensitive free radical production. The latter was associated with enhanced expression of Cu/Zn SOD and endothelial NO synthase. These results suggest that oral administration of CG produces a decrease in blood pressure in normotensive rats. This hemodynamic effect was associated with enhanced endothelium-dependent relaxation and an induction of Cu/Zn SOD and endothelial NO synthase expressions in the vessel wall. They also show subtle mechanisms that compensate for the increased participation of NO to maintain unchanged agonistinduced contractility. These data provide a pharmacological basis for the empirical use of CG against cardiovascular diseases. blood pressure; vasoconstriction CEDRELOPSIS GREVEI (CG) Baill (Meliaceae) is an endemic plant from the southern and western areas of Madagascar empirically used against pulmonary diseases such as cough, tuberculosis, and pneumonia. This plant is also used as an antiasthenic, anti-inflammatory, and antihypertensive drug (4, 5, 10).Different classes of compounds have been isolated from CG including chromones, coumarins, triterpenoids, limonoids, and polyphenols (9,13,20,27). These compounds are known to be biologically active and beneficial against different pathologies such as inflammation, cancer, and cardiovascular diseases (15,19). Among these compounds, the most active are the molecules from the class of polyphenols and coumarins. Indeed, they have been reported to scavenge reactive oxygen species (ROS), inhibit oxidation of low-density lipoprotein, prevent platelet aggregation, induce vasorelaxation, and interact with the nitric oxide (NO) pathway (1,2,14,16,22,23).Very recently, we reported that a crude extract of CG was able to induce relaxation of the rat aorta in both the presence or absence of functiona...

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Cedrelopsis grevei induced hypotension and improved endothelial vasodilatation through an increase of Cu/Zn SOD protein expression

Ranaivo¹,

Rakotoarison²,

Tesse³

et al. 2004

American Journal of Physiology-Heart and Circulatory Physiology

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“…Scoparone exerts strong anti-asthma action by reducing directly the intracellular calcium ion concentration in isolated tracheal smooth muscle (Zhao et al, 2000;Liu et al, 2002;Fang et al, 2003). We have reported elsewhere that scoparone occurs also with other coumarins such as cedrecoumarin and norbraylin in the Malagasy endemic Cedrelopsis grevei (Ptaeorylaceae) which is commonly used in Madagascar to combat fatigue and to treat fever and muscle pain (Mulholland et al, 2002(Mulholland et al, , 2003. However, little is known of the effects of these plants on the whole body and smooth muscle system except for the vasorelaxing properties of scoparone and other coumarins from this source (Rakotoarison et al, 2003).…”

Section: Resultsmentioning

confidence: 99%

Investigations of the Malagasy species Tachiadenus longiflorus Grisebach (Gentianaceae): Linking chemical finding and traditional usage

Randrianarivelojosia

Langlois

Mulholland

2006

Journal of Ethnopharmacology

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“…Regarding to the phytochemistry, C. grevei trunk bark contains chromones, coumarins, acetophenones, triterpenoid derivates and limonoids (Eshiett and Taylor, 1968;Dean and Robinson, 1971;Schulte et al, 1973;Mulholland et al, 1999;Mulholland et al, 2002;Mulholland et al, 2003;Um et al, 2003). A fraction of C. grevei hydroalcoholic trunk bark extract rich in coumarins has been reported to demonstrate a vasodilatatory effect in rat aortic rings .…”

Section: Introductionmentioning

confidence: 99%

Cedrelopsis grevei improves endothelial vasodilatation in aged rats through an increase of NO participation

Mingorance

Andriantsitohaina

Sotomayor

2008

Journal of Ethnopharmacology

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Coumarins from Cedrelopsis grevei (Ptaeroxylaceae)

Cited by 19 publications

References 9 publications

Cedrelopsis grevei induced hypotension and improved endothelial vasodilatation through an increase of Cu/Zn SOD protein expression

Cedrelopsis grevei induced hypotension and improved endothelial vasodilatation through an increase of Cu/Zn SOD protein expression

Investigations of the Malagasy species Tachiadenus longiflorus Grisebach (Gentianaceae): Linking chemical finding and traditional usage

Cedrelopsis grevei improves endothelial vasodilatation in aged rats through an increase of NO participation

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