Coumarin-based Hg2+ fluorescent probe: Fluorescence turn-on detection for Hg2+ bioimaging in living cells and zebrafish

Chemoselective and one-pot synthesis of novel coumarin-based cyclopenta[c]pyrans via base-mediated reaction of α,β-unsaturated coumarins and β-ketodinitriles

“…Furthermore, some substituted coumarins are very favorable to use in perfumes, cosmetics, lasers, radiometric chemosensors, bio-sensors, and living cells imaging. [11][12][13][14] Accordingly, the synthesis of molecules containing the coumarin motif is highly desirable.…”

Flavanone-Based Fluorophores with Aggregation-Induced Emission Enhancement Characteristics for Mitochondria-Imaging and Zebrafish-Imaging

“…Zebrafish is in vitro fertilized and has up to 87% genetic similarity with human. Importantly, the embryo of zebrafish is almost transparent and the internal tissues and organs are observed [ 28 , 29 , 30 , 31 ]. The above results indicated that these flavanones derivatives have a good application prospect in living cell imaging, so for further studies the application of such compounds in bioimaging, zebrafish was selected as the research object.…”

A novel coumarin-based colorimetric and fluorescent probe for detecting increasing concentrations of Hg2+in vitro and in vivo

“…35,36 Coumarin derivatives can also be used as uorescent tags or imaging agents for discriminating tumor lesions and investigating the subcellular localization of drugs. [37][38][39][40][41][42][43][44][45][46] In our research, a novel intramolecular charge transfer (ICT)-based uorescent probe CNS (Scheme 1), employing coumarin as the uorophore and thioacetals as the reacting site for Hg 2+ , was constructed by a facile and highly efficient synthesis strategy. The probe should be highly selective and sensitive to Hg 2+ , because the electron-rich dithioacetal group can be specically and rapidly cleaved in the presence of Hg 2+ .…”