Could Platelet Indices and Neutrophil to Lymphocyte Ratio Be New Biomarkers for Differentiation of Arteritic Anterior Ischemic Neuropathy from Non-Arteritic Type?

İnanç, Merve; Tekin, Kemal; Budakoglu, Ozlem; İlhan, Bayazıt; Aydemir, Önder; Yılmazbaş, Pelin

doi:10.1080/01658107.2017.1405995

Cited by 12 publications

(12 citation statements)

References 47 publications

(47 reference statements)

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“…In our survey, patients with NA-AION showed a significantly lower platelet count and significantly larger platelets than controls. Former investigations have reported a correlation between NA-AION and increased MPV 11 , 13 , 14 , 18 , a result consistent with our study. Furthermore, Stiebel-Kalish et al 30 , in a systematic review and meta-analysis on aspirin use after NA-AION, concluded that there is weak evidence showing a beneficial effect of acetylsalicylic acid in preventing NA-AION in the second eye.…”

Section: Discussionsupporting

confidence: 93%

“…Systemic hypertension, diabetes mellitus, atherosclerosis, and a crowded optic disc are well-known risk factors 3 , 4 . Former reports have suggested that systemic and local inflammation may affect the pathogenesis of NA-AION, by inducing both atherosclerosis and hypercoagulability 5 - 11 . Inflammation is the result of complex interactions between the immune and inflammatory system, which includes neutrophils, macrophages, and lymphocytes.…”

Section: Introductionmentioning

confidence: 99%

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Red Cell Distribution Width (RDW) and Complete Blood Cell Count-Derived Measures in Non-Arteritic Anterior Ischemic Optic Neuropathy

et al. 2021

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Purpose: To assess the role of complete blood cell count (CBC) dimensional indices and CBC-derived measures in non-arteritic anterior ischemic optic neuropathy (NA-AION). Methods: In this retrospective case-control survey, 37 newly diagnosed NA-AION patients and 37 sex- and age-matched cataract controls were enrolled in 2017-2018. On the same day of NA-AION diagnosis, a blood sample was collected and CBC was determined using an automatic blood counter. CBC dimensional indices, such as mean platelet volume (MPV) and red cell distribution width (RDW), and CBC-combined indices, including neutrophil/lymphocyte ratio (NLR), derived NLR [dNLR = neutrophils/(white blood cells - neutrophils)], and platelet/lymphocyte ratio (PLR), were evaluated. Erythrocyte sedimentation rate (ESR) was also measured. Results: Mean platelet count, median MPV, RDW, NLR, and dNLR were 221±48 x 10 9 /L, 8.2 fL (IQR=7.6-8.9), 13% (IQR=12-14.5), 2.50 (IQR=1.77-3.06), and 1.73 (IQR=1.31-2.07) in NA-AION patients and 248±56 x 10 9 /L, 7.60 fL (IQR=7.05-8.25), 12% (IQR=11.6-13), 1.95 (IQR=1.43-2.49) and 1.36 (IQR=1.07-1.69) in controls. NA-AION patients showed significantly lower platelet count (p=0.03) and significantly higher median values of MPV (p=0.01), RDW (p=0.015), NLR (p=0.03), and dNLR (p=0.01). Multivariate logistic regression models disclosed a significant correlation only between higher levels of RDW and NA-AION (p≤0.05). The attributable risk of the association between NA-AION and RDW was 33%. Conclusions: Results suggest that RDW may be somehow involved in the pathogenesis of NA-AION. However, high-quality cohort studies are warranted to confirm whether, or not, an altered RDW may be considered a potential biomarker of this vascular disorder affecting the optic nerve.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Red Cell Distribution Width (RDW) and Complete Blood Cell Count-Derived Measures in Non-Arteritic Anterior Ischemic Optic Neuropathy

et al. 2021

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Section: Discussionmentioning

confidence: 99%

“… 18 An elevated NLR is associated with the functional immune status of chronic inflammation, and may be an independent risk factor for diabetic peripheral neuropathy 19 and nonarteritic anterior ischemic optic neuropathy. 20 The PLR denotes the presence of inflammation in cardiovascular disease 21 and many inflammatory disease and cancers, such as Behçet's disease 22 and endometrial carcinoma. 23 A high neutrophil value is a marker of a nonspecific inflammatory process, while a low lymphocyte value indicates inadequate immune regulation.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of MRI Contrast Enhancement of the Oculomotor Nerve in Ischemic Isolated Oculomotor Nerve Palsy

et al. 2020

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Background and Purpose Contrast enhancement of the oculomotor nerve in MRI was recently noticed in patients with clinical ischemic isolated oculomotor nerve palsy (iIONP). The opinions about whether this is a sign of inflammation and whether or not to administer steroids vary between doctors. The study aimed to determine the associations between this enhancement and vascular-disease risk factors (VRFs) and inflammatory factors in iIONP patients. Methods The study recruited patients who had experienced iIONP during the previous 2 years. They were divided into groups A and B based on whether or not they exhibited an enhanced oculomotor nerve in MRI of the cavernous sinus using thin-section, fat-suppressed, and contrast-enhanced sequences. VRFs, inflammatory factors, and improvement scores were compared between the two groups. Results Most (71.1%) of the 45 included iIONP patients had enhanced oculomotor nerves in MRI. VRFs, periorbital pain, elevated C-reactive protein and erythrocyte sedimentation rate, the neutrophil-to-lymphocyte ratio, and the platelet-to-lymphocyte ratio were not significantly associated with the enhancement. Four of the five patients in group A exhibited an elevated cerebrospinal fluid (CSF) IgG synthesis rate. The improvement score of eight patients who received 80 mg of methylprednisolone in addition to the routine therapy was not significantly different from the scores of the other patients (p=0.485). Conclusions More than half of the iIONP patients had an enhanced oculomotor nerve in MRI. A few of them also had elevated CSF IgG synthesis rate, but no further evidence for inflammation was found. The administration of steroids seemed to have no benefit other than increasing the blood glucose level.

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“…On the other hand, some studies argued that alterations in platelet function and microvascular blood flow are more important than the inflammatory reactions in the pathogenesis of NAION. However, the exact mechanism is still unclear [ 17 ]. These inflammatory markers may be used as predictive factors and new biomarkers for NAION.…”

mentioning

confidence: 99%

Serum Inflammatory Biomarkers in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy

Koçak

Eraydin

Turunç

et al. 2020

Korean J Ophthalmol

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Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common cause of optic neuropathy in patients aged >50 years. NAION presents with acute, painless vision loss, optic disc swelling, and visual field defects in the affected eye. Although the pathological mechanism of NAION has not been elucidated, acute ischemia caused by circulatory insufficiency of the optic nerve head is generally accepted in the pathogenesis of NAION [1,2]. It is thought that multifactorial disorders, wherein different combinations of some local and systemic risk factors, play a role in the development of NAION [3]. While systemic diseases such as diabetes mellitus, hypertension, nocturnal arterial hypotension, ischemic heart disease, cerebrovascular events, and atherosclerosis are

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Could Platelet Indices and Neutrophil to Lymphocyte Ratio Be New Biomarkers for Differentiation of Arteritic Anterior Ischemic Neuropathy from Non-Arteritic Type?

Cited by 12 publications

References 47 publications

Red Cell Distribution Width (RDW) and Complete Blood Cell Count-Derived Measures in Non-Arteritic Anterior Ischemic Optic Neuropathy

Red Cell Distribution Width (RDW) and Complete Blood Cell Count-Derived Measures in Non-Arteritic Anterior Ischemic Optic Neuropathy

Clinical Significance of MRI Contrast Enhancement of the Oculomotor Nerve in Ischemic Isolated Oculomotor Nerve Palsy

Serum Inflammatory Biomarkers in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy

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