Could platelet distribution width be a predictive marker for unexplained recurrent miscarriage?

Ural, Ülkü Mete; Tekın, Yeşim Bayoğlu; Balık, Gülşah; Şahin, Figen Kır; Çolak, Sabri

doi:10.1007/s00404-014-3192-x

Cited by 15 publications

(5 citation statements)

References 27 publications

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“…20 Mete Ural et al stated that the PDW increased with recurrent miscarriage. 21 These results support our finding that the PLT and PCT values were significantly increased in patients with RPL.…”

Section: Discussionsupporting

confidence: 91%

Can Plateletcrit be a Marker for Recurrent Pregnancy Loss?

Aynıoğlu

Işık

Şahbaz

et al. 2014

Clin Appl Thromb Hemost

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Section: Discussionsupporting

confidence: 91%

Can Plateletcrit be a Marker for Recurrent Pregnancy Loss?

Aynıoğlu

Işık

Şahbaz

et al. 2014

Clin Appl Thromb Hemost

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“…In inflammatory processes with an increased risk of thrombosis, PLTs in the circulation increase in number and size, migrating to the site of infection where they should be heavily consumed . As they migrate, they regulate their own functions by changing their shapes and releasing biologically active substances . This may explain the possible mechanisms to understand how PLT indices such as MPV, PDW and PCT are altered in some cases.…”

Section: Discussionmentioning

confidence: 99%

Platelet indices in preterm premature rupture of membranes and their relation with adverse neonatal outcomes

Dündar

Çakmak

Özgen

et al. 2017

J of Obstet and Gynaecol

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Aim: Preterm premature rupture of membranes (PPROM) is not only the most common distinguishable cause of preterm delivery, but is also associated with adverse neonatal outcomes. We determined the platelet indices in PPROM cases and evaluated their relationship to adverse neonatal outcomes. Methods: Fifty patients with PPROM and 50 patients who experienced spontaneous preterm labor at < 37 gestational weeks were evaluated. Complete blood counts, birth weights, Apgar scores, presence of sepsis and respiratory distress syndrome (RDS) and neonatal intensive care unit admission were recorded. Results: Patients with PPROM had increased mean platelet volumes (9.40 vs 10; P = 0.01), plateletcrit (0.19 vs 0.21; P = 0.03) and a higher frequency of neonatal sepsis (18% vs 38%; P = 0.02). Platelet indices in the patient group were compared according to the development of RDS. Plateletcrit values were higher in the RDS positive group (0.23 AE 0.05 vs. 0.21 AE 0.04; P = 0.04). The cut-off value for plateletcrit was determined as > 0.22, and the probability of RDS increased 5.86 times when plateletcrit values exceeded 0.22 (odds ratio 5.86, 95% confidence interval 1.01-32.01; P = 0.04). A one-unit increase in platelet distribution width resulted in a 1.33-fold increase in the risk of RDS (odds ratio 1.33, 95% confidence interval 1.01-1.77; P = 0.04). Conclusion: Mean platelet volumes and plateletcrit significantly increased and plateletcrit had a predictive value for RDS in PPROM cases. Monitoring plateletcrit may be promising for predicting the development of RDS, one of the most common and serious complications of PPROM rupture.

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“…It has been proven that natural prothrombotic events are caused by physiological changes during pregnancy. 4 The hemostatic balance in placental vessels may be altered during pregnancy. These events may cause hypercoagulable states, which may in turn lead to inadequate fetomaternal circulation due to reduced placental perfusion.…”

Section: Introductionmentioning

confidence: 99%

“…However, for most of these factors, the corresponding pathogenesis has not been established. It has been proven that natural prothrombotic events are caused by physiological changes during pregnancy [4]. The hemostatic balance in placental vessels may be altered during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Predictive value of D‐dimer in patients with unexplained recurrent implantation failure during freeze‐thaw embryo transfer cycles

Zeng

et al. 2023

American J Rep Immunol

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Background This study aimed to evaluate whether D‐dimer can predict the clinical outcomes of patients with unexplained recurrent implantation failure (URIF) during freeze‐thaw embryo transfer (FET) cycles. Methods Our study was divided into two parts. The first part was a retrospective study that included 433 patients. Plasma D‐dimer levels were monitored in all patients before FET, and the patients were classified into two groups according to whether they delivered at least one live infant or not. D‐dimer was compared between groups, and receiver operating characteristic (ROC) curves were constructed to analyze the impact of D‐dimer on live birth. The second part was a prospective study that included 113 patients who were categorized into high and low D‐dimer groups based on the ROC curve analysis from the retrospective study. Clinical outcomes were compared between these two groups. Results In the first part, we found that plasma D‐dimer levels in patients with live birth were significantly lower than those in patients without live birth. According to the ROC curve, 0.22 mg/L was the cutoff value for D‐dimer in the prediction of the live birth rate (LBR) (AUC 0.806, 95% CI: 0.763, 0.848). The second part of the study confirmed that clinical pregnancy rate (50.98% vs. 32.26%, P = .044) and LBR (41.18% vs. 22.58%, P = .033) of patients with D‐dimer ≤0.22 mg/L were all significantly higher than those of patients with D‐dimer > 0.22 mg/L. Conclusions Our study indicates that D‐dimer > 0.22 mg/L is a useful index for predicting URIF during FET cycles.

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Could platelet distribution width be a predictive marker for unexplained recurrent miscarriage?

Cited by 15 publications

References 27 publications

Can Plateletcrit be a Marker for Recurrent Pregnancy Loss?

Can Plateletcrit be a Marker for Recurrent Pregnancy Loss?

Platelet indices in preterm premature rupture of membranes and their relation with adverse neonatal outcomes

Predictive value of D‐dimer in patients with unexplained recurrent implantation failure during freeze‐thaw embryo transfer cycles

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