Could mouth rinses be an adjuvant in the treatment of SARS‐CoV‐2 patients? An appraisal with a systematic review

Gandhi, Gargi; Thimmappa, Latha; Upadhya, Nagaraja P; Carnelio, Sunitha

doi:10.1111/idh.12555

Cited by 8 publications

(6 citation statements)

References 69 publications

(154 reference statements)

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“…After checking manually, we omitted four false positives from the shared data papers. One of them used the journal's template: “The data that support the findings of this study are openly available in [repository name] at [DOI]” [ 21 ]. Hence finally, one paper had shared data (0.2%).…”

Section: Resultsmentioning

confidence: 99%

Transparency of COVID-19-Related Research in Dental Journals

Sofi‐Mahmudi

Raittio

2022

Front. Oral. Health

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ObjectiveWe aimed to assess the adherence to transparency practices (data availability, code availability, statements of protocol registration and conflicts of interest and funding disclosures) and FAIRness (Findable, Accessible, Interoperable, and Reusable) of shared data from open access COVID-19-related articles published in dental journals available from the Europe PubMed Central (PMC) database.MethodsWe searched and exported all COVID-19-related open-access articles from PubMed-indexed dental journals available in the Europe PMC database in 2020 and 2021. We detected transparency indicators with a validated and automated tool developed to extract the indicators from the downloaded articles. Basic journal- and article-related information was retrieved from the PMC database. Then, from those which had shared data, we assessed their accordance with FAIR data principles using the F-UJI online tool (f-uji.net).ResultsOf 650 available articles published in 59 dental journals, 74% provided conflicts of interest disclosure and 40% funding disclosure and 4% were preregistered. One study shared raw data (0.15%) and no study shared code. Transparent practices were more common in articles published in journals with higher impact factors, and in 2020 than in 2021. Adherence to the FAIR principles in the only paper that shared data was moderate.ConclusionWhile the majority of the papers had a COI disclosure, the prevalence of the other transparency practices was far from the acceptable level. A much stronger commitment to open science practices, particularly to preregistration, data and code sharing, is needed from all stakeholders.

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Section: Resultsmentioning

confidence: 99%

Transparency of COVID-19-Related Research in Dental Journals

Sofi‐Mahmudi

Raittio

2022

Front. Oral. Health

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“…Increased periodontal pathogens have also been associated with neurological degeneration, particularly smell, in Parkinson's disease [46]. The management of periodontal pathogens via antiseptic mouthwashes is also a recognised clinical approach [47] and has been demonstrated to have efficacy for COVID-19 viral-load reduction [48]. The present work did not ask about mouthwash use, however, as alteration of taste perception can be induced by chlorhexidine itself [49].…”

Section: Differences Between Rapid and Prolonged Recoverymentioning

confidence: 99%

Relationship between Recovery from COVID-19-Induced Smell Loss and General and Oral Health Factors

Catton

Gardner

2022

Medicina

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Background and Objectives: Loss of smell is one of the strongest predictors of coronavirus disease 2019 (COVID-19) and can persist long after other symptoms have resolved. “Long” cases (>28 days) of smell dysfunction present future challenges to medical and dental professionals, as there is a lack of evidence on the causes and any exacerbating or relieving factors. This study aimed to explore the persistence of COVID-19-induced smell loss and association with physical, lifestyle and oral health factors. Materials and Methods: This study was a cross-sectional survey of 235 participants. Recovery of smell was explored, comparing rapid recovery (≤28 days) with prolonged recovery (>28 days). Associative factors included age, sex, illness severity, diet, BMI, vitamin D supplementation, antidepressants, alcohol use, smoking, brushing frequency, flossing, missing teeth, appliances and number of dental restorations. Results: Smell loss showed 87% resolution within 30 days. Prolonged smell loss was significantly associated with older age (mean ± 95%, CI = 31.53 ± 1.36 years for rapid recovery vs. mean ± 95%, CI = 36.0 ± 3 years for prolonged recovery, p = 0.003) and increased self-reported illness severity (mean ± 95%, CI = 4.39 ± 0.27 for rapid recovery vs. 5.01 ± 0.54 for prolonged recovery, p = 0.016). Fisher’s exact test revealed flossing was associated with rapid recovery, with flossers comprising 75% of the rapid-recovery group, compared to 56% in the prolonged-recovery group (odds ratio ± 95%, CI = 2.26 (1.23–4.15), p = 0.01). All other factors were not significantly associated (p > 0.05). Conclusions: Increased age and illness severity were associated with prolonged smell recovery. Use of floss was the only modifiable factor associated with rapid recovery of smell loss. As 87% of cases resolve within 30 days, future studies may benefit from targeted recruitment of individuals experiencing prolonged sense loss. This would increase statistical confidence when declaring no association with the other factors assessed, avoiding type II errors.

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“…Furthermore, this study found that instructions to patients who were diagnosed with COVID‐19 do not seem to have included advice on toothbrush hygiene and care nor on preventing the contamination of surfaces by the generation of aerosol during wet brushing, thus allowing a significant number of patients to continue to adopt toothbrush practices that could predispose cohabitants to the risk of exposure and transmission of SARS‐CoV‐2 in the same household. With that in mind, findings from this study and suggestions by others that aim at reducing the viral load in saliva, 20,21 could inform the public health response to prevent the transmission of SARS‐CoV‐2 and reduce the spread of COVID‐19.…”

Section: Discussionmentioning

confidence: 90%

Are COVID‐19 patients given adequate instructions about toothbrush hygiene? A cross‐sectional study

Al-Khatib

Dalbah

2023

Int J Dental Hygiene

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Objective The aim of this study was to evaluate toothbrush hygienic practices, whether subjects with a positive COVID‐19 test received instructions about toothbrush hygiene, and to determine if carriers of SARS CoV‐2 were assigned separate bathrooms during home isolation. Methods Data were collected by an anonymous online questionnaire. Variables of interest included toothbrush hygiene practices, receiving instructions on toothbrush handling if tested positive for COVID‐19, and being assigned separate bathrooms during home isolation. Results From November 2020 through April 2021; 755 responded (472 [62.5%] females, 269 [35.6%] males, 14 [1.85%] did not specify their gender). 14 (4.1%) of 341 respondents who reported a positive result of a COVID‐19 test received instructions about how to maintain their toothbrush during home isolation. The majority of subjects (74.4%) reported the use of water to wet their toothbrush before brushing, this practice was significantly more common among young subjects (p < 0.001). 58.6% wash all parts of the toothbrush after use while 38.8% wash the head of the toothbrush, and 1.6% place the toothbrush in an antiseptic. 53% used separate bathrooms during isolation, this was significantly associated with age group (p = 0.006) and higher monthly income (p = 0.02). Conclusions The majority of participants with a positive result of the COVID‐19 test were not given explicit instructions about toothbrush handling. Less than half reported good toothbrush hygienic practices. Higher monthly income was significantly associated with using a separate bathroom during home isolation. Providing explicit instructions about toothbrush hygiene is recommended to reduce the spread of contagious diseases such as COVID‐19.

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Could mouth rinses be an adjuvant in the treatment of SARS‐CoV‐2 patients? An appraisal with a systematic review

Cited by 8 publications

References 69 publications

Transparency of COVID-19-Related Research in Dental Journals

Transparency of COVID-19-Related Research in Dental Journals

Relationship between Recovery from COVID-19-Induced Smell Loss and General and Oral Health Factors

Are COVID‐19 patients given adequate instructions about toothbrush hygiene? A cross‐sectional study

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