Cottonseed Oil Protects Against Intestinal Inflammation in Dextran Sodium Sulfate-Induced Inflammatory Bowel Disease

Park, Jin‐Sil; Choi, Jung-Hwa; Hwang, Sung Yeoun; Kim, Jae‐Kyung; Kim, Min Jung; Lee, Seon-Young; Lee, Bo‐In; Park, Sung-Hwan; Cho, Mi‐La

doi:10.1089/jmf.2018.4323

Cited by 26 publications

(45 citation statements)

References 27 publications

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“…It represents a series of chronic relapsingremitting gastrointestinal tract disorders characterized by a persistent intestinal inflammation with clinical symptoms of abdominal pain, blood in stool, weight loss, diarrhea, fatigue, or maldigestion (Hanauer and Hommes, 1996;Yu and Rodriguez, 2017). The precise pathogenesis of IBD is not exactly known, however, some researchers agree that IBD is associated with environmental factors, intestinal microbiota disorder, abnormal autoimmune responses, and genetic susceptibility (Danese and Fiocchi, 2006;Italia and Claudio, 2015;Park et al, 2019). To date, the treatment options of IBD are mainly concentrated on conventional therapies, including non-specific immunosuppressive therapies, antibiotics and anti-inflammatory agents, which have low efficacy and may even cause many side effects (Baumgart and Sandborn, 2007;Yamamoto-Furusho, 2018).…”

Section: Introductionmentioning

confidence: 99%

Algal Oil Rich in n-3 PUFA Alleviates DSS-Induced Colitis via Regulation of Gut Microbiota and Restoration of Intestinal Barrier

Tang

Huang

et al. 2020

Front. Microbiol.

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Algal oil is rich in docosahexaenoic acid (DHA) and has various health benefits against human metabolic disorders and disease. This study aimed to investigate the effects of DHA algal oil on colonic inflammation and intestinal microbiota in dextran sulfate sodium (DSS)-induced colitis mice model. Male C57BL/6 mice was induced colitis by 2.5% DSS and followed by 2 weeks of treatment with algal oil (250 or 500 mg/kg/day). The colonic inflammation was assessed by colon macroscopic damage scores, and the degree of neutrophil infiltration was evaluated by measuring tissue-associated myeloperoxidase (MPO) activity in colonic mucosa. Tight junction proteins in the colonic tissue were measured by real-time PCR and western blot. Moreover, the intestinal microbiota and shot chain fatty acids (SCFAs) were estimated by bioinformatic analysis and GC, respectively. Colonic damage due to DSS treatment was significantly ameliorated by algal oil supplementation. In addition, algal oil significantly inhibited the increases of malondialdehyde (MDA) content, MPO activity, pro-inflammatory cytokines level and tight junction proteins expression in DSS-treated mice. Furthermore, supplementation of algal oil modulated the intestinal microbiota structure in DSS induced colitis mice by increasing the proportion of the unidentified_S24_7 and decreasing the relative abundance of unidentified_Ruminococcaceae, Clostridium and Roseburia. On the analysis of SCFAs, the caecal content of acetic acid, propionic acid, isobutyric acid, buturic, and the total SCFAs showed a significant increase in algal oil-administered mice. Together, these results suggested that algal oil rich in DHA inhibited the progress of DSS-induced colitis in mice by modulating the intestinal microbiota and metabolites and repairing the intestinal barrier, which may be applied in the development of therapeutics for intestinal inflammation.

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Section: Introductionmentioning

confidence: 99%

Algal Oil Rich in n-3 PUFA Alleviates DSS-Induced Colitis via Regulation of Gut Microbiota and Restoration of Intestinal Barrier

Tang

Huang

et al. 2020

Front. Microbiol.

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“…TNF‐ α is an important cytokine during the onset of inflammatory responses, as it promotes T cell differentiation and proliferation, the destruction of the intestinal barrier, and the rapid development and progression of intestinal inflammation 41 . IL‐1 β is also an essential cytokine in the early stages of inflammation, provoking continuous inflammatory responses in colon tissues 42 . After SePSP treatment, therefore, the substantial reduction in the mRNA levels of the proinflammatory cytokines, TNF‐ α and IL‐1 β , in the colon tissues of mice with DSS‐induced UC indicated that SePSP has potential immunomodulatory efficacy in the treatment of colitis.…”

Section: Discussionmentioning

confidence: 99%

Purification and antioxidant and anti‐Inflammatory activity of extracellular polysaccharopeptide from sanghuang mushroom, Sanghuangporus lonicericola

et al. 2020

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BACKGROUNDSanghuang mushrooms are medicinal fungi widely used in eastern Asia. In this study, the antioxidant and anti‐inflammatory activity of a novel extracellular polysaccharopeptide, sanghuang extracellular polysaccharopeptide (SePSP) was investigated. The SePSP was purified from the submerged fermentation broth of a sanghuang mycelium, Sanghuangporus lonicericola strain CBS17, which was isolated from a wild sanghuang fruiting body.RESULTSThe SePSP was extracted using an ethanol precipitation procedure, followed by diethylaminoethanol (DEAE) anion‐exchange and size‐exclusion chromatography. The mass ratio of the polysaccharide and peptide components in the purified SePSP was approximately 4.87:1. By determining its free radical scavenging abilities using 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH), the hydroxyl free radical, and the superoxide anion free radical, as well as its total reducing power, SePSP was shown to have strong concentration‐dependent antioxidant activity in vitro. Further, SePSP effectively alleviated dextran sodium sulfate (DSS)‐induced ulcerative colitis (UC) in mice. Administration of 200 mg kg−1 SePSP by gavage for 7 days prevented body weight loss; significantly reduced the mRNA levels of proinflammatory cytokines, including TNF‐α and IL‐1β; increased mRNA level of the anti‐inflammatory cytokine IL‐10 in the colon, and decreased the malondialdehyde concentration from 6.42 to 4.82 μmol L−1 in the blood in UC mice.CONCLUSIONThe SePSP had strong concentration‐dependent antioxidant activity in vitro and effectively alleviated DSS‐induced UC in mice. The in vivo therapeutic efficacy in DSS‐induced UC may be mediated by modulating the expression of inflammatory cytokines and inhibiting oxidative stress. The findings provide a scientific rationale for the use of bioactive nutraceuticals from sanghuang mushrooms to develop functional foods for the prevention and treatment of UC. © 2020 Society of Chemical Industry

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“…A prospective study including 412 patients with quiescent UC treated with an aminosalicylate, reported that dietary intake of myristic acid, a SFA commonly found in palm oil, coconut oil and dairy fats was associated with increased risk of a flare (OR 3.01; 95% CI: 1.17-7.74) [30]. Coconut oil could not demonstrate a beneficial effect in DSS-induced colitis in mice [144].…”

Section: Coconut Oilmentioning

confidence: 99%

Food and Food Groups in Inflammatory Bowel Disease (IBD): The Design of the Groningen Anti-Inflammatory Diet (GrAID)

Campmans-Kuijpers

Dijkstra

2021

Nutrients

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Diet plays a pivotal role in the onset and course of inflammatory bowel disease (IBD). Patients are keen to know what to eat to reduce symptoms and flares, but dietary guidelines are lacking. To advice patients, an overview of the current evidence on food (group) level is needed. This narrative review studies the effects of food (groups) on the onset and course of IBD and if not available the effects in healthy subjects or animal and in vitro IBD models. Based on this evidence the Groningen anti-inflammatory diet (GrAID) was designed and compared on food (group) level to other existing IBD diets. Although on several foods conflicting results were found, this review provides patients a good overview. Based on this evidence, the GrAID consists of lean meat, eggs, fish, plain dairy (such as milk, yoghurt, kefir and hard cheeses), fruit, vegetables, legumes, wheat, coffee, tea and honey. Red meat, other dairy products and sugar should be limited. Canned and processed foods, alcohol and sweetened beverages should be avoided. This comprehensive review focuses on anti-inflammatory properties of foods providing IBD patients with the best evidence on which foods they should eat or avoid to reduce flares. This was used to design the GrAID.

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Cottonseed Oil Protects Against Intestinal Inflammation in Dextran Sodium Sulfate-Induced Inflammatory Bowel Disease

Cited by 26 publications

References 27 publications

Algal Oil Rich in n-3 PUFA Alleviates DSS-Induced Colitis via Regulation of Gut Microbiota and Restoration of Intestinal Barrier

Algal Oil Rich in n-3 PUFA Alleviates DSS-Induced Colitis via Regulation of Gut Microbiota and Restoration of Intestinal Barrier

Purification and antioxidant and anti‐Inflammatory activity of extracellular polysaccharopeptide from sanghuang mushroom, Sanghuangporus lonicericola

Food and Food Groups in Inflammatory Bowel Disease (IBD): The Design of the Groningen Anti-Inflammatory Diet (GrAID)

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