Cotonoates A and B, New Aromatic Esters from Cotoneaster racemiflora

Khan, Shafiq Ahmad; Yasmeen, Shazia; Afza, Nighat; Malik, Abdul; Iqbal, Lubna; Lateef, Mehreen

doi:10.1515/znb-2008-1013

Cited by 10 publications

(8 citation statements)

References 3 publications

(2 reference statements)

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“…Plants belonging this genus commonly called as "Dağ muşmulası or Tavşan elması" in the different region of Anatolia. In addition, the Cotoneaster species are widely used as culinary plants in different countries including Turkey (Baytop, 1999;Cakilcioglu and Turkoglu, 2010;Khan et al, 2008). Previously, some bioactive compounds were reported in the genus (El-Mousallamy et al, 2000;Khan et al, 2008;Sokkar et al, 2013;Zengin et al, 2014) but so far, there is no information about biological activities and chemical fingerprint of C. integerrimus.…”

Section: Introductionmentioning

confidence: 99%

Chemical and biological insights on Cotoneaster integerrimus: A new (-)- epicatechin source for food and medicinal applications

et al. 2016

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Section: Introductionmentioning

confidence: 99%

Chemical and biological insights on Cotoneaster integerrimus: A new (-)- epicatechin source for food and medicinal applications

et al. 2016

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“…Nevertheless, in a set of identified phenolic acids, chlorogenic ( 28 ) and ferulic ( 29 ) acids were noted as the most abundant phenolics in the twigs and fruits of C. integerrimus [ 24 ], the leaves of C. meyeri [ 23 ], the leafy twigs of C. nummularia [ 7 ], and the leafy twigs of C. horizontalis [ 26 ]. Apart from typical phenolic acids, lesser-known compounds, including esters of benzoic and terephthalic acids, named cotonoates A ( 43 ), B ( 44 ), and horizontoates A ( 45 ), B ( 46 ), were isolated from the leafy twigs of C. racemiflora and C. horizontalis , respectively [ 27 , 28 ].…”

Section: Phytochemical Composition Of the Genus Cotoneasmentioning

confidence: 99%

“…Cotoneaster species, as the most widespread plants in East Asia, are also natural medicines with a long traditional use in Iran, Pakistan, Turkey, Mongolia, and Tibet [ 5 , 27 , 45 , 46 ]. Numerous species are known to the local community for their diuretic, astringent, expectorant, hepatoprotective, digestive, cardiotonic, antiviral, and spasmolytic properties.…”

Section: Biological Activities Of the Genus Cotoneaster mentioning

confidence: 99%

An Overview of the Genus Cotoneaster (Rosaceae): Phytochemistry, Biological Activity, and Toxicology

Kicel

2020

Antioxidants

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Traditional herbal medicines have become a subject of global importance with both medical and economic implications. The regular consumption of herbal drugs has led to serious concerns regarding their quality, effectiveness, and safety. Thus, relevant scientific evidence has become an important criterion for the acceptance of traditional health claims. The genus Cotoneaster Medikus provides numerous species traditionally used in Asian medicine for the treatment of haemorrhoids, diabetes, and cardiovascular diseases. This review summarises the achievements of modern research on the Cotoneaster taxa, including ethnobotany, phytochemistry, pharmacology, and toxicology. To date, more than 90 compounds have been isolated or analytically identified in Cotoneaster leaves, fruits, flowers or twigs. These phytochemicals are categorised into flavonoids, procyanidins, phenolic acids, cotonefurans, cyanogenic glycosides, triterpenes, sterols, fatty acids, volatile compounds, and carbohydrates, and many of them are responsible for Cotoneaster pharmacological properties including antioxidant, anti-inflammatory, antimicrobial, antiparasitic, hepatoprotective, anti-diabetic or anti-dyslipidaemic activity. In order to ensure the safety of pharmaceutical applications, the potential toxicity of Cotoneaster extracts has also been investigated. In conclusion, this systematic review provides an important reference base for further study into the various medical applications of both the dry extracts and pure isolates of Cotoneaster species.

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“…Racemiside, scopoletin, 7,8-dimethoxy-6-hydroxycoumarin, 3,3',4'-tri-O-methylellagic acid, and cereotagloperoxide isolated from the ethyl acetate-soluble fraction of Cotoneaster racemiflora, showed profound antioxidative activities in the DPPH assay [129].Free radical scavenging activity measured by 1,1diphenyl-2-picryl-hydrazil (DPPH) showed that methyl 3,4-dihydroxy-5-methoxybenzoate isolated from the plant possessed significant antioxidant (IC 50: 9.7±0.12µm). The spectrophotometric method showed that the same compound exerted lipoxygenase inhibitory activities (IC 50: 19.5±0.07 µm) [130].Antioxidant capacities of ethyl acetate, methanol and water extracts of the plant were evaluated by free radical scavenging assay (DPPH, ABTS and O 2 ), reducing power, phosphomolybdenum, β-carotene/linoleic acid bleaching and metal chelating assays. The highest DPPH and O 2 scavenging activities were exerted by water extract of the plant, followed by the methanol extract.…”

Section: Cotoneaster Racemifloramentioning

confidence: 99%

Medicinal plants with antioxidant and free radical scavenging effects (part 2): plant based review

Al-Snafi¹

2016

IOSRPHR

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Previous studies showed that a wide range of medicinal plants exerted antioxidant and free radical scavenging activity. These plants included: Cicer arietinumThe free radicals scavenging, antioxidant properties and intestinal α-glucosidase inhibitory activity of methanol extract of two varieties of Cicer arietinum were evaluated. Compared with raw seeds increase in total polyphenol and flavonoids concentration in green gram sprouts and Kabuli Chana sprouts (KCs) were recorded. Total protein concentrations in sprouts did not differ from non-sprouted grains. 2,2'-Azinobis (3-ethyl benzthiazoline-6-sulphonic acid) cation scavenging activity was more than twice in Bengal gram sprouts of (BGs) and KCs than their raw seeds. 2,2-diphenyl-1-picrylhydrazyl, hydrogen peroxide scavenging, nitro blue tetrazolium reducing and glucose-induced Hb-glycation inhibitory activity did not differ from non-sprouted raw grains. Increase in rat intestinal α-glucosidase inhibitory activity was observed in BGs and KCs. BGs significantly mitigated first 30 min starch-induced postprandial glycemic excursions and reduced 2 h postprandial glycemic load [44][45].The extent of free radical scavenging properties and antioxidant effects of crude extracts of sprouted Cicer arietinum (Chick pea/Chana/Bengal gram) seeds were evaluated. Two main varieties of Cicer arietinum seeds viz. Kabuli-Chana (cream seed-coat) and Bengal gram (brown seed-coat) were examined and compared for their free radical scavenging properties and antioxidant effects. Free radical scavenging properties were evaluated against stable 2, 2-diphenyl-1-picrylhydrazyl radical (DPPH) and hydrogen peroxide radical and the Medicinal plants with antioxidant and free radical scavenging 63 extent of antioxidant effect was assessed by lipid peroxidation induced by ferrous sulphate on the lipid present in the liver homogenate. The results showed that the two Cicer arietinum extracts were differed in their capacities to quench or inhibit DPPH, hydrogen peroxide and lipid peroxide. Brown colored Cicer arietinum sprouts showed the greatest activity against DPPH radicals, hydrogen peroxide radicals and lipid peroxide compared to the cream variety [45][46].The root of Cicer arietinum was extracted using solvents of different polarities and explored for in vitro free radical scavenging activity. Preliminary assays of three different extracts of Cicer arietinum root showed that the extracts possess electron donating ability and reduction of ferric ion to ferrous in a cell free system at pH-7.4. It has also been found from total antioxidant capacity as assessed by reduction of molybdate showed Cicer arietinum root extracts to possess (standard) ascorbic acid equivalents per milligrams of the extracts. Hydroalcoholic root extract was found more effective when compared to alcoholic and water extracts in scavenging 1, 1-diphenyl-2-picrylhydrazyl, reducing ferric ion and molybdate reduction in antioxidant capacity. A significant correlations exist between extract concentrations and percentage scaveng...

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Cotonoates A and B, New Aromatic Esters from Cotoneaster racemiflora

Cited by 10 publications

References 3 publications

Chemical and biological insights on Cotoneaster integerrimus: A new (-)- epicatechin source for food and medicinal applications

Chemical and biological insights on Cotoneaster integerrimus: A new (-)- epicatechin source for food and medicinal applications

An Overview of the Genus Cotoneaster (Rosaceae): Phytochemistry, Biological Activity, and Toxicology

Medicinal plants with antioxidant and free radical scavenging effects (part 2): plant based review

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