Costus pictus–transition from a medicinal plant to functional food: A review

Selvakumarasamy, Saranya; Rengaraju, Balakrishnaraja; Arumugam, Siddhu Adhiaman; Ramalakshmi, K.

doi:10.1016/j.fufo.2021.100068

Cited by 9 publications

(5 citation statements)

References 37 publications

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“…It is found that alpha and beta amyrins are the main active compounds thought to be responsible for the therapeutic effects ( Ashwini et al., 2017 ). Interestingly, silver nanoparticles of C. pictus methanolic extracts have shown a surge in phenolic and flavonoid contents and increased antioxidant activity ( Selvakumarasamy et al., 2021 ). Therefore, evaluating the nanoformulations on the hypothyroidism animal model is recommended.…”

Section: Medicinal Plants Controlling Thyroid Hormones Disordersmentioning

confidence: 99%

“…Costus pictus, also known as insulin plant, fiery Costus , and spiral flag ( Selvakumarasamy et al., 2021 ) is widely used in the traditional management of diabetes, and its methanolic extract has shown synergistic antidiabetic effect with metformin in the alloxan-induced diabetic model ( Naik et al., 2022 ). The main active compounds in this plant are alpha and beta amyrin.…”

Section: Medicinal Plants Controlling Thyroid Hormones Disordersmentioning

confidence: 99%

See 1 more Smart Citation

Medicinal plants’ proposed nanocomposites for the management of endocrine disorders

Zarzour

Kamarulzaman

Saqallah

et al. 2022

Heliyon

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Section: Medicinal Plants Controlling Thyroid Hormones Disordersmentioning

confidence: 99%

Section: Medicinal Plants Controlling Thyroid Hormones Disordersmentioning

confidence: 99%

Medicinal plants’ proposed nanocomposites for the management of endocrine disorders

Zarzour

Kamarulzaman

Saqallah

et al. 2022

Heliyon

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“…Another species Costus pictus commonly known as American Insulin Plant was introduced recently in India (Figure 16B). Flavonoid quercetin is present in the leaves which exhibit antidiabetic, antioxidant and hepatoprotective properties (Selvakumarasamy et al 2021). The leaves of Costus pictus (American Insulin plant) and the rhizome of Costus speciosus (Indian Insulin plant) are good source to lower down the blood sugar level due to hypoglycemic properties (Azhagu and Ganesan 2021; Sharma and Sharma 2021).…”

Section: Anti-diabetic Plantsmentioning

confidence: 99%

Traditional Phytotherapy by Medicinal Plants: A Review

2022

Medicinal Plants: Ethnomedicine, Pharmacognosy and Therapeutic Values

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This reviewed chapter deals with important ethno-medicinal plants used as anti-cancer, anti-viral, anti-bacterial, anti-oxidant and anti-asthmatic plants. A wide variety of medicinal plants are being used as a primary source against various diseases in different systems of medicine like Ayurveda, Siddha, and Unani. The traditional knowledge of medicinal plants has been an integral part of our lifestyle since ancient times. Plants around the world have special medicinal and diagnostic properties. Medicinal plants contain various phytochemical compounds like alkaloids, flavonoids, steroids, phenols, tannin, glycosides, etc. This chapter has been extensively reviewed for the use of different plant parts containing active phytochemicals and their response on different types of diseases. Different plant species synthesize metabolites that possess many biological activities such as anti-diabetic, anti-oxidant, anti-cancer, anti-viral, anti-bacterial, anti-asthmatic, antiinflammatory etc. that have been used in drug development through clinical trials. Synthetic drugs have a narrow therapeutic window with several adverse side effects. Due to this disadvantage of synthetic drugs, there is a growing trend in the field of research to find new and reputable medicines based on the development of various herbs.

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“…Recent research has evaluated this plant’s antidiabetic potential [ 6 , 7 ]. The phytochemical profile of Saussurea costus evidenced the presence of carbohydrates, triterpenoids, proteins, alkaloids, tannins, saponins, flavonoids, and steroids as active ingredients [ 8 ], which contributes to the diverse qualities [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Lactiplantibacillus plantarum and Saussurea costus as Therapeutic Agents against a Diabetic Rat Model—Approaches to Investigate Pharmacophore Modeling of Human IkB Kinase and Molecular Interaction with Dehydrocostus Lactone of Saussurea costus

et al. 2023

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Lactic acid bacteria is well-known as a vital strategy to alleviate or prevent diabetes. Similarly, the plant Saussurea costus (Falc) Lipsch is a preventive power against diabetes. Here, we aimed to determine whether lactic acid bacteria or Saussurea costus is more effective in treating a diabetic rat model in a comparative study manner. An in vivo experiment was conducted to test the therapeutic activity of Lactiplantibacillus plantarum (MW719476.1) and S. costus plants against an alloxan-induced diabetic rat model. Molecular, biochemical, and histological analyses were investigated to evaluate the therapeutic characteristics of different treatments. The high dose of S. costus revealed the best downregulated expression for the IKBKB, IKBKG, NfkB1, IL-17A, IL-6, IL-17F, IL-1β, TNF-α, TRAF6, and MAPK genes compared to Lactiplantibacillus plantarum and the control groups. The downregulation of IKBKB by S. costus could be attributed to dehydrocostus lactone as an active compound with proposed antidiabetic activity. So, we performed another pharmacophore modeling analysis to test the possible interaction between human IkB kinase beta protein and dehydrocostus lactone as an antidiabetic drug. Molecular docking and MD simulation data confirmed the interaction between human IkB kinase beta protein and dehydrocostus lactone as a possible drug. The target genes are important in regulating type 2 diabetes mellitus signaling, lipid and atherosclerosis signaling, NF-κB signaling, and IL-17 signaling pathways. In conclusion, the S. costus plant could be a promising source of novel therapeutic agents for treating diabetes and its complications. Dehydrocostus lactone caused the ameliorative effect of S. costus by its interaction with human IkB kinase beta protein. Further, future studies could be conducted to find the clinical efficacy of dehydrocostus lactone.

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Costus pictus–transition from a medicinal plant to functional food: A review

Cited by 9 publications

References 37 publications

Medicinal plants’ proposed nanocomposites for the management of endocrine disorders

Medicinal plants’ proposed nanocomposites for the management of endocrine disorders

Traditional Phytotherapy by Medicinal Plants: A Review

Lactiplantibacillus plantarum and Saussurea costus as Therapeutic Agents against a Diabetic Rat Model—Approaches to Investigate Pharmacophore Modeling of Human IkB Kinase and Molecular Interaction with Dehydrocostus Lactone of Saussurea costus

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