Cost study of dermal substitutes and topical negative pressure in the surgical treatment of burns

Hop, M.J.; Bloemen, M.C.T.; Baar, Margriet E. van; Nieuwenhuis, M.K.; Zuijlen, Paul P. M. van; Polinder, Suzanne; Middelkoop, Esther

doi:10.1016/j.burns.2013.08.025

Cited by 18 publications

(20 citation statements)

References 25 publications

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“…In the current study, burn center stay was a major component of the health care and nonhealth‐care costs (societal costs) for both treatment groups, which is in line with other studies on burn care costs . Productivity loss (nonhealth‐care costs) represented the second largest part of societal costs in both treatment groups (enzyme alginogel group 24%, SSD 26%, respectively).…”

Section: Discussionsupporting

confidence: 88%

“…Productivity loss (nonhealth‐care costs) represented the second largest part of societal costs in both treatment groups (enzyme alginogel group 24%, SSD 26%, respectively). Two Dutch studies found comparable results ranging between 25% and 30% . A Spanish study by Sanchez found that loss of productivity accounted for 80% of societal costs .…”

Section: Discussionmentioning

confidence: 93%

“…Costs of personnel time per hour were based on the gross salary of the nurses, increased with a surcharge for holiday allowance and social charges . Personnel, material, and equipment costs of surgery were obtained from a previous Dutch study by Hop et al Personnel costs were multiplied by time (surgical and anesthesia team) needed for each operation recorded in the current study. For each patient, information on reconstructive surgery, use of blood products, pressure clothes and silicone therapy were recorded prospectively during hospital admission and the follow‐up period up to 12 months postburn.…”

Section: Methodsmentioning

confidence: 99%

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Long‐term quality of life and cost‐effectiveness of treatment of partial thickness burns: A randomized controlled trial comparing enzyme alginogel vs silver sulfadiazine (FLAM study)

Rashaan

Krijnen

Kwa

et al. 2020

Wound Repair Regeneration

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The clinical effectiveness and scar quality of the randomized controlled trial comparing enzyme alginogel with silver sulfadiazine (SSD) for treatment of partial thickness burns were previously reported. Enzyme alginogel did not lead to faster wound healing (primary outcome) or less scar formation. In the current study, the healthrelated quality of life (HRQoL), costs, and cost-effectiveness of enzyme alginogel compared with SSD in the treatment of partial thickness burns were studied. HRQoL was evaluated using the Burn Specific Health Scale-Brief (BSHS-B) and the EQ-5D-5L questionnaire 1 week before discharge and at 3, 6, and 12 months postburn. Costs were studied from a societal perspective (health care and nonhealth-care costs) for a follow-up period of 1 year. A cost-effectiveness analysis was performed using costeffectiveness acceptability curves and comparing differences in societal costs and Quality Adjusted Life Years (QALYs) at 1 year postburn. Forty-one patients were analyzed in the enzyme alginogel group and 48 patients in the SSD group. None of the domains of BSHS-B showed a statistically significant difference between the treatment groups. Also, no statistically significant difference in QALYs was found between enzyme alginogel and SSD (difference −0.03; 95% confidence interval [CI], −0.09 to 0.03; P = .30). From both the health care and the societal perspective, the difference Abbreviation: BSHS-B, Burn Specific Health Scale-Brief; HRQoL, Health-related quality of life; ICER, incremental cost-effectiveness ratio; SSD, silver sulfadiazine; TBSA, total body surface area;QALYs, quality adjusted life years; VAT, Visual Analogue Thermometer.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 93%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Long‐term quality of life and cost‐effectiveness of treatment of partial thickness burns: A randomized controlled trial comparing enzyme alginogel vs silver sulfadiazine (FLAM study)

Rashaan

Krijnen

Kwa

et al. 2020

Wound Repair Regeneration

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“…As a result, reducing medical expenditures may also have the potential to reduce health care costs. A study by Hop et al examined costs of various types of grafts with and without NPWT in burn patients . In that study, the authors did not find significant differences in the mean total cost per patient between patients with dermal substitutes with or without NPWT and those with STSGs with or without NPWT.…”

Section: Discussionmentioning

confidence: 99%

Use of negative pressure wound therapy in burn patients

Teng

2016

International Wound Journal

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According to previous research, adjunctive negative pressure wound therapy (NPWT) can help manage infected wounds when applied along with appropriate debridement and antibiotic therapy as deemed clinically relevant. NPWT not only removes fluid, and reduces oedema, but also promotes perfusion around the wounds. In addition, NPWT may lead to improved graft fixation when used as a bolster, especially in patients who are less compliant or have poor graft fixation that result from using traditional methods. NPWT is a good choice to bolster skin grafts in young, active and less-compliant patients. We propose an enhanced segmental compartment-covered technique, which uses NPWT adjunctively as first-line wound treatment to help manage postoperative infection. Moreover, NPWT promotes granulation tissue formation to prepare the wound bed for subsequent skin graft and may be used as a bolster over the graft, which helps to attain skin graft viability.

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“…Though the total costs among dermal substitutes group culminated higher expenses per patient (2218 Euros), this was not significantly higher than the skin graft only group (1703 Euros). 18 Interestingly, indirect health-related costs such as length of hospital stay and overheads were found to be the most important factors influencing the total cost of treatment. The decision to use dermal substitutes may therefore be a clinical one.…”

Section: Clinical Indications and Outcomes Of Dermal Skin Substitutesmentioning

confidence: 99%

Dermal Skin Substitutes for Upper Limb Reconstruction

2014

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Cost study of dermal substitutes and topical negative pressure in the surgical treatment of burns

Cited by 18 publications

References 25 publications

Long‐term quality of life and cost‐effectiveness of treatment of partial thickness burns: A randomized controlled trial comparing enzyme alginogel vs silver sulfadiazine (FLAM study)

Long‐term quality of life and cost‐effectiveness of treatment of partial thickness burns: A randomized controlled trial comparing enzyme alginogel vs silver sulfadiazine (FLAM study)

Use of negative pressure wound therapy in burn patients

Dermal Skin Substitutes for Upper Limb Reconstruction

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