“…The coefficient of variation, defined as standard deviation compared to the mean, was 0.15 and 0.38, for EDSS II and III, respectively, for all 12 studies including EDSS estimates of costs. Concerning the mildest severity categorization, hereafter called EDSS I, seven out of ten studies that specified costs per category identified MS treatment as the main cost driver [26,[37][38][39][40][41][42]. The cost driver varied more between studies in the moderate severity group, EDSS II, where it was identified as drugs or MS treatment [37,[39][40][41], permanent reductions in productive work [26,38,43], other classifications of indirect costs [57,58], and informal care [42].…”