Cost of illness of liver diseases in Japan

Matsumoto, Kunichika; Wu, Yufei; Fujita, Shigeru; Seto, Kanako; Hatakeyama, Yosuke; Onishi, Ryo; Hasegawa, Tomonori

doi:10.1016/j.aohep.2020.08.073

Cited by 6 publications

(6 citation statements)

References 23 publications

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“…As in the United States Japan, Europe, the United Kingdom, Iran, the Middle East, and other developed and developing countries, the burden of fatty liver certainly is increased in future. 4,7,[22][23][24][25][26][27][28][29][30] The study from France, Germany, Italy, Spain, the United Kingdom, and the United States in 2018 found that the mean total cost/per patient/year for NASH was €2763, €4917, and €5509 for direct medical, direct nonmedical, and indirect costs, respectively. 23 Another study included five countries in Europe that estimated total economic costs were €8548-19 546 M. Of these, health system costs were €619-1292 M, and total well-being costs were €41 536-90 379 M. 4 This study is similar to the current study in increasing cost with the severity of the disease.…”

Section: Discussionmentioning

confidence: 99%

Estimating the cost of illness of non‐alcoholic fatty liver disease in Bangladesh

Alam,

Islam Alin,

Begum

et al. 2023

JGH Open

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Background and AimNon‐alcoholic fatty liver disease (NAFLD) is a growing concern, affecting about 45 million of the Bangladeshi population. There is a paucity of research on the economic burden of NAFLD. The study aims to estimate the cost of illness of NAFLD in Bangladesh.MethodsIn this prospective, cross‐sectional study, a total of 250 patients of NAFLD, non‐alcoholic steatohepatitis (NASH), and NASH cirrhosis were included from public and private hospitals. Costs of hospitalization, physician fees, investigation costs, expenditures on medical procedures, drugs; and nonmedical costs such as transport expenses and other informal payments (tips) were estimated.ResultsThe overall cost per patient per evaluation was (16.90–46 942.00) USD. The cost in public and private hospitals was 384.76 and 1146.93 USD, respectively. The cost per patient of NAFLD was 157.91 (16.90–955.08) USD, and for NASH cirrhosis was 1783.80 (422.48–46 942) USD. The cost of illness increased to USD 281.18 for diabetics and 254.52 USD for hypertensive. If all the NAFLD patients are evaluated once in healthcare settings, the projected cost will be 7.11 billion USD. In NAFLD, cost for investigations, medicines, transportation, and consultation of physicians was 49.08%, 32.41%, 11.11%, and 6.67%, respectively.ConclusionsNAFLD is causing a huge economic burden to the healthcare system. The cost of illness is increased with NASH cirrhosis. Overall, this study provides valuable insights into the economic burden of NAFLD in Bangladesh and emphasizes the several ways of intervention to reduce the cost by preventive measures and accessible healthcare for affected individuals.

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Section: Discussionmentioning

confidence: 99%

Estimating the cost of illness of non‐alcoholic fatty liver disease in Bangladesh

Alam,

Islam Alin,

Begum

et al. 2023

JGH Open

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“…We estimated the disease burden from a societal perspective and estimated the COI generated per year every 3 years in a time series for future estimates. We used the same estimation method that has been developed by Rice et al and To refer future population that we had previously used to estimate the COIs of other diseases [35][36][37][38][39][40][41][42][43].…”

Section: Methodsmentioning

confidence: 99%

“…Thus, it represents an appropriate method for studying the relationship between social aging and disease burden. We have also previously COI to estimate the social burden of different diseases [35][36][37][38][39][40][41][42][43].…”

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confidence: 99%

Cost of illness in a super-aged society—comparison of breast, lung, and prostate cancer in Japan

et al. 2022

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Background Aging increases the disease burden because of an increase in disease prevalence and mortality among older individuals. This could influence the perception of the social burden of different diseases and treatment prioritization within national healthcare services. Cancer is a disease with a high disease burden in Japan; however, the age-specific frequency and age-specific mortality rates differ according to site. In this study, we evaluated the relationship between the aging of the Japanese society and the disease burden by comparing the features of three cancers with different age-specific frequency rates in Japan. Furthermore, we made projections for the future to determine how the social burden of these cancers will change. Methods We calculated the social burden of breast, lung, and prostate cancers by adding the direct, morbidity, and mortality costs. Estimates were made using the cost of illness (COI) method. For future projections, approximate curves were fitted for mortality rate, number of hospital admissions per population, number of outpatient visits per population, and average length of hospital stay according to sex and age. Results The COI of breast, lung, and prostate cancers in 2017 was 903.7, 1,547.6, and 390.8 billion yen, respectively. Although the COI of breast and prostate cancers was projected to increase, that of lung cancer COI was expected to decrease. In 2017, the average age at death was 68.8, 76.8, and 80.7 years for breast, lung, and prostate cancers, respectively. Conclusions Patients with breast cancer die earlier than those with other types of cancer. The COI of breast cancer (“young cancer”) was projected to increase slightly because of an increase in mortality costs, whereas that of prostate cancer (“aged cancer”) was projected to increase because of an increase in direct costs. The COI of lung cancer (“aging cancer”) was expected to decrease in 2020, despite the increase in deaths, as the impact of the decrease in human capital value outweighed that of the increase in deaths. Our findings will help prioritize future policymaking, such as cancer control research grants.

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“…Currently there is a great food and nutrition problem that is increasing, due to the poor quality of nutrients contained in them on the one hand and on the other hand the excess of carbohydrates which is one of the factors that triggers the problem of fatty liver which is simply the initial stage of more serious diseases such as cirrhosis and cancer [1][2][3][4][5][6][7][8]. Thus, the relationship between diseases and diet is increasingly con rmed [9][10].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Natural Hepatoprotectors and Added Foods by Photoacoustic Spectroscopy and Colorimetry

Saucedo-Alfonzo

Domínguez-Pacheco

Hernández-Aguilar

et al. 2022

Preprint

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The current pandemic events make it necessary to develop foods with a higher content of nutrients that have a better impact on the health of the population. The improvement of daily food mixtures by adding nutraceutical materials with bioactive substances has a favorable effect on food products and consumers. In the present study, photoacoustic spectroscopy and colorimetry were used to characterize hepatoprotective plants and tortillas added with black radish (2 and 8%) and black radish and turmeric (3%). The main findings were: 1) Of the evaluated hepatoprotectants Silybum marianum, Peumus boldus and Raphanus sativus; the black radish peel is the one that presents the highest level of photoacoustic signal at the wavelength (250 -900 nm). 2) The “tortillas” characterized by PAS and colorimetry, presented a positive correlation between the photoacoustic signal at the wavelength of 450 nm. and the color variables a* and b*. Likewise, there is a correlation between the color parameter L* and the amplitude of the photoacoustic signal at the wavelength of 350 nm. 3). The dehydration process modifies the color of the tortilla, being the variable L*, the most affected and to a lesser degree a* and b*. The PAS technique and colometry permit the study of naturals hepatoprotectors, and blends of cornmeal added with black radish.

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Cost of illness of liver diseases in Japan

Cited by 6 publications

References 23 publications

Estimating the cost of illness of non‐alcoholic fatty liver disease in Bangladesh

Estimating the cost of illness of non‐alcoholic fatty liver disease in Bangladesh

Cost of illness in a super-aged society—comparison of breast, lung, and prostate cancer in Japan

Characterization of Natural Hepatoprotectors and Added Foods by Photoacoustic Spectroscopy and Colorimetry

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