Cost-Effectiveness of the Strategies to Reduce the Incidence of Dengue in Colima, México

Abstract

Dengue fever is considered to be one of the most important arboviral diseases globally. Unsuccessful vector-control strategies might be due to the lack of sustainable community participation. The state of Colima, located in the Western region of Mexico, is a dengue-endemic area despite vector-control activities implemented, which may be due to an insufficient health economic analysis of these interventions. A randomized controlled community trial took place in five urban municipalities where 24 clusters were included. The study groups (n = 4) included an intervention to improve the community participation in vector control (A), ultra-low volume (ULV) spraying (B), both interventions (AB), and a control group. The main outcomes investigated were dengue cumulative incidence, disability-adjusted life years (DALYs), and the direct costs per intervention. The cumulative incidence of dengue was 17.4%, A; 14.3%, B; 14.4%, AB; and 30.2% in the control group. The highest efficiency and effectiveness were observed in group B (0.526 and 6.97, respectively) and intervention A was more likely to be cost-effective ($3952.84 per DALY avoided) followed by intervention B ($4472.09 per DALY avoided). Our findings suggest that efforts to improve community participation in vector control and ULV-spraying alone are cost-effective and may be useful to reduce the vector density and dengue incidence.

The cost-effectiveness of controlling dengue in Indonesia using wMel Wolbachia released at scale: a modelling study

“…A number of previous studies have attempted to estimate the cost-effectiveness of vector control interventions for dengue [23,[40][41][42][43]. The methods used tend to fall into one of two approaches: field trials or modelbased assessments.…”

“…The methods used tend to fall into one of two approaches: field trials or model-based assessments. Experimental and observational control trials have been used to estimate cost-effectiveness (per DALY averted) for larvicides in Cambodia ($313) [ 40 ], community clear up campaigns ($3953) and ultra-low volume spraying ($4472) in Mexico [ 42 ], and an integrated package of vector control interventions in Sri Lanka ($98) [ 43 ]. Short-term control trials with disease endpoints are likely to overestimate effectiveness due to the effects of heard immunity and may mean interventions delay rather than avert disease.…”

Integrated vector management with additional pre-transmission season thermal fogging is associated with a reduction in dengue incidence in Makassar, Indonesia: Results of an 8-year observational study

“…The strategy we describe here has the advantage of only modifying existing procedures by altering the timing and locations of fogging. While the costs for increased surveys and fogging might be greater, they are almost certainly outweighed by the savings in reduced dengue incidence [38, 39]. Since Ae .…”

The potential cost-effectiveness of controlling dengue in Indonesia using wMel Wolbachia released at scale: a modelling study

“…The methods used tend to fall into one of two approaches: field trials or model-based assessments. Experimental and observational control trials have been used to estimate cost-effectiveness (per DALY averted) for larvicides in Cambodia ($313) [31], community clear up campaigns ($3,953) and ultra-low volume spraying ($4,472) in Mexico [33] and an integrated package of vector control interventions in Sri Lanka ($98) [34]. Short-term control trials with disease endpoints are likely to overestimate effectiveness due to the effects of heard immunity and may mean interventions delay rather than avert disease.…”