Cost-effectiveness of hepatitis A vaccination in children, adolescents, and adults

Rosenthal, Philip

doi:10.1053/jhep.2003.50016

Cited by 62 publications

(40 citation statements)

References 60 publications

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“…One the one hand, in the highly endemic regions, it is almost impracticable to identify the groups at risk for acquiring the disease; and on the other, the high cost of vaccine makes it difficult to extend this benefit to the entire population. [45][46][47] Israel was the first country to adopt universal vaccination for children at 18 and 24 months of age in June 1999, and the results were excellent. 48 A very recent analysis of the impact of this program, 5.5 years after it began, reveals that an important decline has been observed in the incidence of the disease in all age groups, with 90%…”

Section: Impact Of Anti-hav Vaccinationmentioning

confidence: 99%

“…49 Children at pre-school age must be the main focus of immunization strategies, because of their critical role in virus transmission. 21, [45][46][47]50 As has been demonstrated by different studies, the efficient way to diminish incidence of the disease and even eradicate the infection is mass vaccination of children. There are, however, many barriers to this measure being adopted, among them: the growing number of vaccinations in childhood, other public health priorities, the cost of vaccine and the reduced number of cost-effectiveness studies of this strategy for our country.…”

Section: Impact Of Anti-hav Vaccinationmentioning

confidence: 99%

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Prevenção das hepatites virais através de imunização

Ferreira¹,

Silveira²

2006

J. Pediatr. (Rio J.)

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Objective: To present an updated review and criticism of viral hepatitis A and B prevention by immunization. Summary of the findings: Viral hepatitis prevention is an enormous challenge to the public health systems of countries and the medical and scientific communities. Hepatitis viruses produce important morbimortality in the world, causing acute and chronic hepatic disease. There are highly efficient vaccines available on the market to prevent new infections by the A and B viruses. However, A and B viruses continue to be among the most commonly notified diseases preventable by vaccines. In this article, we discuss the vaccines used to prevent these infections, with the aim of expanding knowledge and the practice of prevention of these infectious diseases.Conclusions: Although the vaccines against A and B hepatitis are recommended for various risk groups, estimated vaccine coverage is still modest and many vaccination opportunities are lost. In order to reduce the incidence of A and B hepatitis, which are preventable by vaccines, it is necessary for physicians to encourage their patients to be vaccinated.

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Section: Impact Of Anti-hav Vaccinationmentioning

confidence: 99%

Section: Impact Of Anti-hav Vaccinationmentioning

confidence: 99%

Prevenção das hepatites virais através de imunização

Ferreira¹,

Silveira²

2006

J. Pediatr. (Rio J.)

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“…Nowadays Hepatitis A vaccine is recommended in USA and Israel [25,26]. Rosenthal P. [27] reviewed some economical analysis about Hepatitis A vaccine and he concluded that its economical benefit is similar the other vaccines that are included in the routine child immunization program. Besides this, it is economically acceptable for adolescents and adults who have a high risk to get this disease.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis A: the costs and benefits of the disease prevention by vaccine, Paraná, Brazil

Zahdi¹,

Maluf²,

Maluf³

2009

Braz J Infect Dis

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This study evaluated the epidemiological behavior of the hepatitis A in Paraná state and compared the costs of the disease and the vaccination. This is an epidemiological descriptive study including a pharmacoeconomy analysis. We collected information in the national database reported cases (SINAN), in the mortality information system (SIM) and in the hospital information system (AIH) among 2000/2003 (Paraná State Public Health Department). We estimated the probability of one cohort of children to acquire hepatitis A during their lifetime and the costs with their treatment. We compared those costs with the cost of vaccinating the children. 14,682 hepatitis A cases were registered during the period studied, and 12,102 (82.4%) occurred in the 0-15 years-old age group. The annual incidence in the general population was 37.5/100,000. We observed 20 deaths caused by this disease; 7 of those occurred by liver failure. The estimated costs with the disease included the hospital costs, liver transplantation, liver failure treatment, and laboratory tests were high. The price of the vaccine is 10 USD/dose. Two doses are necessary to get the protection. The results showed a positive cost -benefit relation when we vaccinate children. We save 2.26 USD in treatment for each dollar invested in the vaccine. Paraná record high number of hepatitis A cases each year. We confirmed the positive costbenefit relation when we vaccinate children against hepatitis A, reducing suffering, hospitalization, death and social costs. Vaccination against hepatitis A should be recommended in the routine of immunization program in Paraná state.

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“…Nas localidades do semi-árido do Nordeste, especialmente os de menor porte, como Cavunge, a poluição ambiental é talvez o maior determinante de várias doenças de transmissão fecal-oral e decorrente de múltiplos fatores, tanto sanitários como culturais 4 .…”

Section: Discussionunclassified

Aspectos sociodemográficos da soroprevalência de marcadores do vírus da hepatite A no povoado de Cavunge, região do semi-árido do Estado da Bahia

Almeida

Tavares-Neto

Queiroz-Andrade

et al. 2006

Rev. Soc. Bras. Med. Trop.

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A hepatite A costuma ser assintomática e apenas cerca de 20% dos casos desenvolve doença clinicamente manifesta, com graus variáveis de gravidade. Ocorre esporadicamente ou de forma epidêmica e a disseminação viral ocorre, sobretudo, em ambientes com precárias condições sociohigiênicas 2 .A infecção é mais freqüente na infância, especialmente entre os menores de 5 anos de idade 6 . Em conseqüência disto e das características da transmissão do vírus da hepatite A (VHA), a melhoria dos indicadores de desenvolvimento humano tem grande impacto sobre a disseminação e transmissão viral 7 .O diagnóstico laboratorial da infecção pelo VHA se faz na fase aguda, com a pesquisa dos anticorpos IgM anti-VHA, os quais tem títulos elevados até a 4ª e a 6ª semana pós-infecção e que desaparecem após o 4º mês do início da mesma 5 ABSTRACTIn Cavunge community, a rural pvillage of the dry tropic in Bahia State, Brazil, a sentinel study on viral hepatitis was developed to characterize the seroprevalence of hepatitis A. The presence of IgG anti-HAV was analyzed in 891 citizens and 85.9% were positive. The prevalence was similar between genders and increased with age. Key-words: hepatitis A virus. Epidemiology. Serological markers of hepatitis. Cavunge. Bahia. perceptíveis desde o início do processo infeccioso e que perduram por longo tempo, ou por toda a vida 9 . Por conta desta característica do anti-VHA IgG e pelas características associadas à transmissão do VHA, foi planejado o estudo de soroprevalência na população do Povoado de Cavunge (município de Ipecaetá, Estado da Bahia), onde também a investigação das condições sanitárias e ambientais permite avaliar possíveis inter-relações com aquela infecção viral. MATERIAL E MÉTODOSO estudo seccional de base populacional foi realizado no ano de 2000. A população de referência é de 2.049 pessoas, com idades entre 7 dias e 95 anos. Aqueles que aceitaram participar do estudo assinaram o termo de consentimento

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Cost-effectiveness of hepatitis A vaccination in children, adolescents, and adults

Cited by 62 publications

References 60 publications

Prevenção das hepatites virais através de imunização

Prevenção das hepatites virais através de imunização

Hepatitis A: the costs and benefits of the disease prevention by vaccine, Paraná, Brazil

Aspectos sociodemográficos da soroprevalência de marcadores do vírus da hepatite A no povoado de Cavunge, região do semi-árido do Estado da Bahia

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