Cost‐Effectiveness of Clinical Breast Assessment‐Based Screening in Rural Egypt

Denewer, Adel; Hussein, Osama; Farouk, Omar; Elnahas, Waleed; Khater, Ashraf; El-Saed, Aiman

doi:10.1007/s00268-010-0620-3

Cited by 28 publications

(19 citation statements)

References 29 publications

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“…Consequently, practitioners in our country adopted a concept of limited utility of mammography as a screening tool not only because of its cost but also because of the youth of the target population. We previously proposed a breast cancer screening program based on clinical breast examination with selective use of mammography, and we rationaled our proposal on the decreased accuracy of mammography at young ages 16. The data in the current study and other recent reports from Egyptian databases indicate a trend towards an age distribution shift from the midfifties to the early sixties 7,17.…”

Section: Discussionmentioning

confidence: 51%

Hormone Receptors and Age Distribution in Breast Cancer Patients at a University Hospital in Northern Egypt

Hussein

Mosbah

Farouk

et al. 2013

Breast Cancer�(Auckl)

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Introduction:Breast cancer is the most common cancer among Egyptian women. The disease is often advanced at diagnosis. Since molecular profiling is not feasible in routine practice, we sought to examine the association of age distribution with hormone receptor profile, disease stage and outcome among Egyptian women.Patients and methods:We conducted a retrospective review of breast cancer patients treated at Mansoura University Cancer Center in the Nile Delta from 2006 through 2011. Age groups were examined in relation to hormone receptors status and tumor clinicopathological criteria. Additionally, the effect of receptor status on disease relapse and disease-free survival was examined with logistic regression and Kaplan–Meier analysis.Results:A total of 263 patients were included in the current analysis. About 66.9% (n = 176) of patients were hormone receptor positive, 14.1% (n = 37) were Her2/neu positive, and 19.0% (n = 50) were triple negative. Median age of the patients was 52 years and was equal across all receptor status types. Triple negative status correlated with increased risk of disease relapse (odds ratio = 1.8, P = 0.03) and with shortened disease-free survival (hazards ratio = 2.6, P < 0.01).Conclusion:The age distribution and receptor status pattern in the Nile Delta region does not explain the aggressive behavior of the disease. The age of the patients at diagnosis is older than patients in earlier studies from Egypt emphasizing the importance of implementing mammographic screening programs.

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Section: Discussionmentioning

confidence: 51%

Hormone Receptors and Age Distribution in Breast Cancer Patients at a University Hospital in Northern Egypt

Hussein

Mosbah

Farouk

et al. 2013

Breast Cancer�(Auckl)

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“…Finally, widespread screening CBE (and even programs to promote high-quality evaluation and CBE of symptomatic women) may entail substantial numbers of patients with falsepositive results presenting to referral facilities [47,49,57]. Thus, there is a strong need to identify efficient screening protocols and for clinical algorithms to evaluate symptomatic women that can be used at various levels of a low-resource health care system.…”

Section: Early Detection and Screeningmentioning

confidence: 99%

Breast Cancer in Sub-Saharan Africa: Challenges and Opportunities to Reduce Mortality

2016

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The objective of this review is to describe existing data on breast cancer incidence and mortality in low-and middleincome countries (LMICs), in particular in sub-Saharan Africa; identify the limitations of these data; and review what is known about breast cancer control strategies in sub-Saharan African countries and other LMICs. Available estimates demonstrate that breast cancer incidence and mortality are rising in LMICs, including in Africa, although high-quality data from LMICs (and particularly from sub-Saharan Africa) are largely lacking. Case fatality rates from breast cancer appear to be substantially higher in LMICs than in high-income countries. Significant challenges exist to developing breast cancer control programs in LMICs, perhaps particularly in sub-Saharan Africa, and the most effective strategies for treatment and early detection in the context of limited resources are uncertain. High-quality research on breast cancer incidence and mortality and implementation research to guide effective breast cancer control strategies in LMICs are urgently needed. Enhanced investment in breast cancer research andtreatment in LMICs should be a global public health priority. The Oncologist 2016;21:739-744Implications for Practice: The numbers of new cases of breast cancer, and breast cancer deaths per year, in low-and middle-income countries are rising. Engagement by the international breast cancer community is critical to reduce global disparities in breast cancer outcomes. Cancer specialists and institutions in high-income countries can serve as key partners in training initiatives, clinical care, protocol and program development, and research. This article provides an overview of what is known about breast cancer incidence, mortality, and effective strategies for breast cancer control in sub-Saharan Africa and identifies key gaps in the literature. This information can help guide priorities for engagement by the global cancer community.

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“…Most importantly, the median age (52 years) of BC in Lebanon is lower than the western population (63 years) but higher than the Arab countries (e.g., 46 years in Egypt) [6–8]. Nonetheless, Lebanese age-specific incidence rate is the highest worldwide for the 35–39 and 40–49 age groups with the exception of Israeli Jews in the 35–39 age group [9, 10]. …”

Section: Introductionmentioning

confidence: 99%

Breast Density and Breast Cancer Incidence in the Lebanese Population: Results from a Retrospective Multicenter Study

Salem

Atallah

Safi

et al. 2017

BioMed Research International

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Purpose To study the distribution of breast mammogram density in Lebanese women and correlate it with breast cancer (BC) incidence. Methods Data from 1,049 women who had screening or diagnostic mammography were retrospectively reviewed. Age, menopausal status, contraceptives or hormonal replacement therapy (HRT), parity, breastfeeding, history of BC, breast mammogram density, and final BI-RADS assessment were collected. Breast density was analyzed in each age category and compared according to factors that could influence breast density and BC incidence. Results 120 (11.4%) patients had BC personal history with radiation and/or chemotherapy; 66 patients were postmenopausal under HRT. Mean age was 52.58 ± 11.90 years. 76.4% of the patients (30–39 years) had dense breasts. Parity, age, and menopausal status were correlated to breast density whereas breastfeeding and personal/family history of BC and HRT were not. In multivariate analysis, it was shown that the risk of breast cancer significantly increases 3.3% with age (P = 0.005), 2.5 times in case of menopause (P = 0.004), and 1.4 times when breast density increases (P = 0.014). Conclusion Breast density distribution in Lebanon is similar to the western society. Similarly to other studies, it was shown that high breast density was statistically related to breast cancer, especially in older and menopausal women.

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Cost‐Effectiveness of Clinical Breast Assessment‐Based Screening in Rural Egypt

Abstract: Clinical breast assessment-based screening with selective mammography is an effective modality, which improves the results of breast cancer management in Egypt.

Cited by 28 publications

References 29 publications

Hormone Receptors and Age Distribution in Breast Cancer Patients at a University Hospital in Northern Egypt

Hormone Receptors and Age Distribution in Breast Cancer Patients at a University Hospital in Northern Egypt

Breast Cancer in Sub-Saharan Africa: Challenges and Opportunities to Reduce Mortality

Breast Density and Breast Cancer Incidence in the Lebanese Population: Results from a Retrospective Multicenter Study

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