Hormone Receptors and Age Distribution in Breast Cancer Patients at a University Hospital in Northern Egypt

Abstract

Introduction:Breast cancer is the most common cancer among Egyptian women. The disease is often advanced at diagnosis. Since molecular profiling is not feasible in routine practice, we sought to examine the association of age distribution with hormone receptor profile, disease stage and outcome among Egyptian women.Patients and methods:We conducted a retrospective review of breast cancer patients treated at Mansoura University Cancer Center in the Nile Delta from 2006 through 2011. Age groups were examined in relation to hormone receptors status and tumor clinicopathological criteria. Additionally, the effect of receptor status on disease relapse and disease-free survival was examined with logistic regression and Kaplan–Meier analysis.Results:A total of 263 patients were included in the current analysis. About 66.9% (n = 176) of patients were hormone receptor positive, 14.1% (n = 37) were Her2/neu positive, and 19.0% (n = 50) were triple negative. Median age of the patients was 52 years and was equal across all receptor status types. Triple negative status correlated with increased risk of disease relapse (odds ratio = 1.8, P = 0.03) and with shortened disease-free survival (hazards ratio = 2.6, P < 0.01).Conclusion:The age distribution and receptor status pattern in the Nile Delta region does not explain the aggressive behavior of the disease. The age of the patients at diagnosis is older than patients in earlier studies from Egypt emphasizing the importance of implementing mammographic screening programs.

Correlation between Cancer Breast Subtypes and Age at Presentation in Egyptian Patients; Single Institution Experience

“…The incidence of Her2 positive tumors in the current study was 28.5% but this figure has to take into consideration that our institute is a referral center for the targeted therapy trastuzumab so though our results were in accordance with Salhia et al [21] who reported on an incidence of 25.1%, it was different from Hussein et al who reported on an incidence as low as 14.1% [20].…”

“…In the current study there was a statistically significant difference in distribution of molecular subtypes by age (P-value: 0.031), so though Hormonal positive tumors (luminal subtype) in general was the predominant subtype among all age groups, HR+/Her+ were higher in the younger age group (27% compared to 17.2%) and Her2 overexpression subtype was higher in the younger age group (17.6% compared to 8.2%). Triple negative tumors had the incidence of 16.7% in the current study compared to 19.0% reported by Hussein et al [20], and 28.5% in a report of Elhawary et al who reported on 274 surgical specimens [28]. High frequency of the basal-like subtype has been reported in about 40% of young premenopausal African North American women [29].…”

Impact of Age, Tumor Size, Lymph Node Metastasis, Stage, Receptor Status and Menopausal Status on Overall Survival of Breast Cancer Patients in Pakistan

“…The mean age at diagnosis in our study was 47.5 years which is very similar to that reported in other Asian studies. However, in western population the mean age at diagnosis, as published by Surveillance, Epidemiology and End results (SEER) is 61 years (Hussein O et al, 2013). Majority of our patients presented with nodal involvement, larger tumor size and receptor (ER and PR) positivity.…”

Receptor-Defined Subtypes of Breast Cancer in Indigenous Populations in Africa: A Systematic Review and Meta-Analysis

“…*These studies provided only a combined HR estimate for tumors that were either ER+ or PR+ [33] or ER+ and/or PR+ ([29]; [43]; [52]; [63]; [64]; [71]). These HR estimates were included in both the ER+ and PR+ plots.…”