Cost-Effectiveness of Adjuvanted Influenza Vaccination of Healthy Children 6 to 60 Months of Age

Marchetti, Monia; Kühnel, Ursula M.; Colombo, Giorgio L; Esposito, Susanna; Principi, Nicola

doi:10.4161/hv.3.1.3657

Cited by 45 publications

(29 citation statements)

References 45 publications

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“…Although one previous modeling study examined influenza vaccination scenarios for children over two years old in Thailand [8], our study assessed the cost-effectiveness of vaccinating younger children against seasonal influenza illness using IIV3 based on empirical cost and outcome data from a cohort study over three influenza seasons. Our findings are consistent with those previously reported from other countries that influenza vaccination among young children is typically economically advantageous from a societal perspective[28–32]. The findings highlight that performance of an influenza vaccine program is closely linked with VE, which varies from year to year depending on the match of circulating viruses to vaccine strains.…”

Section: Discussionsupporting

confidence: 92%

Cost-effectiveness of inactivated seasonal influenza vaccination in a cohort of Thai children ≤60 months of age

et al. 2017

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BackgroundVaccination is the best measure to prevent influenza. We conducted a cost-effectiveness evaluation of trivalent inactivated seasonal influenza vaccination, compared to no vaccination, in children ≤60 months of age participating in a prospective cohort study in Bangkok, Thailand.MethodsA static decision tree model was constructed to simulate the population of children in the cohort. Proportions of children with laboratory-confirmed influenza were derived from children followed weekly. The societal perspective and one-year analytic horizon were used for each influenza season; the model was repeated for three influenza seasons (2012–2014). Direct and indirect costs associated with influenza illness were collected and summed. Cost of the trivalent inactivated seasonal influenza vaccine (IIV3) including promotion, administration, and supervision cost was added for children who were vaccinated. Quality-adjusted life years (QALY), derived from literature, were used to quantify health outcomes. The incremental cost-effectiveness ratio (ICER) was calculated as the difference in the expected total costs between the vaccinated and unvaccinated groups divided by the difference in QALYs for both groups.ResultsCompared to no vaccination, IIV3 vaccination among children ≤60 months in our cohort was not cost-effective in the introductory year (2012 season; 24,450 USD/QALY gained), highly cost-effective in the 2013 season (554 USD/QALY gained), and cost-effective in the 2014 season (16,200 USD/QALY gained).ConclusionThe cost-effectiveness of IIV3 vaccination among children participating in the cohort study varied by influenza season, with vaccine cost and proportion of high-risk children demonstrating the greatest influence in sensitivity analyses. Vaccinating children against influenza can be economically favorable depending on the maturity of the program, influenza vaccine performance, and target population.

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Section: Discussionsupporting

confidence: 92%

Cost-effectiveness of inactivated seasonal influenza vaccination in a cohort of Thai children ≤60 months of age

et al. 2017

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“…One review study in Europe found that the vaccine effectiveness was moderate to good, and that the safety of non-adjuvanted trivalent inactivated influenza vaccines was excellent among children [32]. In addition, the vaccination among children was also a cost-effective approach for preventing influenza disease burden [33]. How to enhance pre-school children’s vaccination coverage rate will be an ongoing challenge for public-health workers.…”

Section: Discussionmentioning

confidence: 99%

Determinants of Receiving the Pandemic (H1N1) 2009 Vaccine and Intention to Receive the Seasonal Influenza Vaccine in Taiwan

Chan

Wang

et al. 2014

PLoS ONE

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ObjectivesThe paper examines the factors associated with both receiving pandemic (H1N1) 2009 vaccines and individuals’ intentions to get the next seasonal influenza vaccine in Taiwan.MethodsWe conducted a representative nationwide survey with in-person household interviews during April–July 2010. Multivariate logistic regression incorporated socio-demographic background, household characteristics, health status, behaviors, and perceptions of influenza and vaccination.ResultsWe completed interviews with 1,954 respondents. Among those, 548 (28.0%) received the pandemic (H1N1) 2009 vaccination, and 469 (24.0%) intended to get the next seasonal influenza vaccine. Receipt of the H1N1 vaccine was more prevalent among schoolchildren, the elderly, those who had contact with more people in their daily lives, and those who had received influenza vaccinations in previous years. In comparison, the intention to receive the next seasonal influenza vaccine tended to be stronger among children, the elderly, and those who reported less healthy status or lived with children, who received a seasonal influenza vaccination before, and who worried more about a possible new pandemic.ConclusionsChildren, the elderly, and those who had gotten seasonal flu shots before in Taiwan were more likely to both receive a pandemic H1N1 vaccination and intend to receive a seasonal influenza vaccine.

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“…Given their ubiquity, there has been surprisingly little research examining the costs associated with childhood respiratory infections that has involved collecting primary data from families. Even for influenza, the most studied of all respiratory viruses, cost-of-illness and vaccine cost-effectiveness evaluations in children have tended to rely on assumptions or use retrospectively collected estimates, often from surveys, for resource utilisation, such as carer time away from work in seeking healthcare or caring for an ill child [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

The cost of community-managed viral respiratory illnesses in a cohort of healthy preschool-aged children

et al. 2008

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Background: Acute respiratory illnesses (ARIs) during childhood are often caused by respiratory viruses, result in significant morbidity, and have associated costs for families and society. Despite their ubiquity, there is a lack of interdisciplinary epidemiologic and economic research that has collected primary impact data, particularly associated with indirect costs, from families during ARIs in children.

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Cost-Effectiveness of Adjuvanted Influenza Vaccination of Healthy Children 6 to 60 Months of Age

Cited by 45 publications

References 45 publications

Cost-effectiveness of inactivated seasonal influenza vaccination in a cohort of Thai children ≤60 months of age

Cost-effectiveness of inactivated seasonal influenza vaccination in a cohort of Thai children ≤60 months of age

Determinants of Receiving the Pandemic (H1N1) 2009 Vaccine and Intention to Receive the Seasonal Influenza Vaccine in Taiwan

The cost of community-managed viral respiratory illnesses in a cohort of healthy preschool-aged children

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