The cost of community-managed viral respiratory illnesses in a cohort of healthy preschool-aged children

Lambert, Stephen B.; Allen, Kelly M.; Carter, Rob; Nolan, Terence M.

doi:10.1186/1465-9921-9-11

Cited by 78 publications

(81 citation statements)

References 52 publications

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“…10 In an Australian cohort of pre-school aged children followed by a diary and parent-collected specimens for viral detection, the mean cost of a respiratory picornavirus (rhinovirus or enterovirus) illness was 267 Australian dollars (154 D ) and picornaviruses were associated with the highest overall costs during the study, compared with other respiratory viruses. 11 Otitis media accounts for a substantial proportion of the disease burden in children caused by rhinovirus. In a cohort study following children from 2 months to 2 years of age, rhinovirus was detected in nasopharyngeal sample in 40% of acute otitis media episodes.…”

Section: Burden Of Rhinovirus Infections In the Communitymentioning

confidence: 99%

Clinical effects of rhinovirus infections

Peltola

Waris

Österback

et al. 2008

Journal of Clinical Virology

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Section: Burden Of Rhinovirus Infections In the Communitymentioning

confidence: 99%

Clinical effects of rhinovirus infections

Peltola

Waris

Österback

et al. 2008

Journal of Clinical Virology

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“…Children have the highest rates of infection, have the highest rates of hospitalization due to laboratory‐confirmed influenza and are the principal agents of transmission in communities 1, 2, 3, 4. Annual vaccination is the most effective method for preventing influenza and its complications.…”

Section: Introductionmentioning

confidence: 99%

Safety and tolerability of a 2009 trivalent inactivated split‐virion influenza vaccine in infants, children and adolescents

Lambert

Chuk

Nissen

et al. 2013

Influenza Resp Viruses

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ObjectiveTo evaluate the safety of CSL's split‐virion inactivated trivalent 2009 Southern Hemisphere formulation influenza vaccine (TIV) in children.MethodsWe enrolled 1992 healthy children into three groups: Cohorts A, ≥6 months to <3 years; B, ≥3 years to <9 years; and C, ≥9 years to <18 years. Children received one or two doses of 0·25 ml (22·5 μg haemagglutinin) or 0·5 ml (45 μg) TIV, depending on age and prior vaccination history. We collected post‐vaccination solicited adverse event (AE) data (days 0–6), including fever (temperature: ≥37·5°C axilla, ≥38·0°C oral), unsolicited AEs (days 0–29) and serious AEs (SAEs) and new‐onset chronic illnesses (NOCIs; to day 180 after last vaccination).ResultsAt least one solicited AE was reported by 80%/78%/78% of children in Cohorts A, B and C, respectively. Systemic AEs were more common among Cohort A (72% of participants), and local AEs were more common among Cohort C (71% of participants). Fever was more common in younger cohorts, in influenza vaccine‐naïve children (29% of Cohort A receiving their first dose), and following first compared with second doses. Severe fever following a first dose prevented 20 participants receiving their second scheduled vaccine dose. A 7‐month‐old participant had a single uncomplicated febrile convulsion on the day of vaccination.ConclusionsNearly 80% of subjects reported at least one solicited AE following immunization. Fever prevalence was highest in vaccine‐naïve Cohort A participants, similar to other paediatric studies using CSL vaccine. Further research to understand fever‐related AEs in children following CSL's TIV is recommended.

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“…Além disso, a morbidade infantil associada às creches tem implicações econômicas, pois as doenças acarretam um aumento na utilização de serviços de saúde e nos gastos familiares com assistência médica e medicamentos 9 . No entanto, estudos sobre a etiologia viral das IRAs em crianças que frequentam creches são relativamente poucos na literatura 10 .…”

Section: Introductionunclassified

Frequent respiratory pathogens of respiratory tract infections in children attending daycare centers

Bonfim¹,

Nogueira²,

Simas³

et al. 2011

J Pediatr (Rio J)

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Objectives: To identify and characterize respiratory viruses that infect children from daycare centers with symptoms of respiratory infection and to evaluate the association of clinical and epidemiological disease data with the identified virus. Methods:We conducted a study between 2003 and 2005 in 176 children with respiratory infection symptoms attending a municipal daycare center. Samples from nasopharyngeal secretion were tested by reverse transcriptase polymerase chain reaction and positive samples for picornavirus were sequenced.Results: All 782 collected samples were analyzed and 31.8% were positive for at least one of the studied respiratory viruses. Respiratory infections were characterized by the presence of mild symptoms of the upper respiratory tract, the most common of which were runny nose and cough. In the 2 years of study, most cases of infection occurred in autumn and winter, but respiratory viruses were detected throughout all the study period. Conclusions:Respiratory viruses and respiratory infections caused by them are part of the daily life of children attending daycare centers. Our results show the great impact that respiratory infections have on these children and suggest that more attention must be paid to viral pathogens. Resultados: Todas as 782 amostras coletadas foram analisadas, e 31,8% foram positivas para algum dos vírus respiratórios estudados. As infecções respiratórias foram caracterizadas pela presença de sintomas moderados do trato respiratório superior, sendo os mais comuns coriza e tosse. Em 2 anos de estudo, a maioria dos casos de infecção ocorreram no outono e no inverno, mas vírus respiratórios foram detectados ao longo de todo o período de estudo. J Pediatr (Rio J) Conclusões:Vírus respiratórios e as infecções respiratórias causadas por eles fazem parte do cotidiano de crianças que frequentam creches. Nossos resultados mostram o grande impacto gerado pelas infecções respiratórias nessas crianças e sugere que uma maior atenção deve ser dispensada aos patógenos virais.J Pediatr (Rio J). 2011;87(5):439-44: Vírus respiratórios, infecção respiratória aguda, crianças de creche.

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The cost of community-managed viral respiratory illnesses in a cohort of healthy preschool-aged children

Cited by 78 publications

References 52 publications

Clinical effects of rhinovirus infections

Clinical effects of rhinovirus infections

Safety and tolerability of a 2009 trivalent inactivated split‐virion influenza vaccine in infants, children and adolescents

Frequent respiratory pathogens of respiratory tract infections in children attending daycare centers

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