Cost‐Effective Control Strategies for Johne's Disease in Dairy Herds

Cho, Jaesung; Tauer, Loren W.; Schukken, Y.H.; Smith, Rebecca L.; Lu, Zhao; Gröhn, Yrjö T.

doi:10.1111/j.1744-7976.2012.01270.x

Cited by 26 publications

(30 citation statements)

References 33 publications

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“…Economic modeling, based in part on the estimated milk loss associated with infection, has been used to recommend control strategies (Cho et al, 2012, 2013; Dorshorst et al, 2006). Many of these models have assumed that all infections eventually develop into clinical disease.…”

Section: Introductionmentioning

confidence: 99%

The effects of progressing and nonprogressing Mycobacterium avium ssp. paratuberculosis infection on milk production in dairy cows

Smith

Gröhn

Pradhan

et al. 2016

Journal of Dairy Science

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Longitudinal data from 3 commercial dairy herds in the northeast United States, collected from 2004 to 2011, were analyzed to determine the effect of Mycobacterium avium subsp. paratuberculosis (MAP) infection status and progression path on milk production. Disease status, as indicated by MAP test results, was determined through quarterly ELISA serum testing, biannual fecal culture, and culture of tissues and feces at slaughter. Milk production data were collected from the Dairy Herd Information Association. Animals with positive MAP test results were categorized, based on test results over the full course of the study, as high path (at least one high-positive culture) or low path (at least one positive culture or ELISA). The cumulative number of positive ELISA and culture results were recorded. The effects of both MAP infection path, status, and number of positive tests on milk production were analyzed using a mixed linear model with an autocorrelation random effect structure. Low and high path animals produced more milk prior to their first positive test than always-negative animals, especially high path animals. While mean production decreased after a first positive test, low path animals were shown to recover some productivity. High path animals continued to exhibit a decrease in milk production, especially after their first high-positive fecal culture. These results show that not all animals that test positive for MAP will have long-term production losses. Milk production decreased significantly with each additional positive test. Ultimately, production loss appeared to be a function of MAP infection progression.

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Section: Introductionmentioning

confidence: 99%

The effects of progressing and nonprogressing Mycobacterium avium ssp. paratuberculosis infection on milk production in dairy cows

Smith

Gröhn

Pradhan

et al. 2016

Journal of Dairy Science

Self Cite

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“…Nonetheless, these increasing cull costs reflect both the considerable cost differences in culling animals in different stages of infection (SI[infected], SI[infectious], and SI[affected]), noting the lack of salvage value for SI [affected] animals and the overall number of animals potentially culled. This underlines the importance of early identification of infected animals, before they progress to SI [affected], and changes to herd management (Dorshorst et al, 2006) over the long-term (Cho et al, 2013) to limit ongoing transmission (and further infected animals). Caution is required when comparing culling costs associated with each testing strategy.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of testing strategies to identify infected animals at a single round of testing within dairy herds known to be infected with Mycobacterium avium ssp. paratuberculosis

Cameron

Strain

et al. 2015

Journal of Dairy Science

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As part of a broader control strategy within herds known to be infected with Mycobacterium avium ssp. paratuberculosis (MAP), individual animal testing is generally conducted to identify infected animals for action, usually culling. Opportunities are now available to quantitatively compare different testing strategies (combinations of tests) in known infected herds. This study evaluates the effectiveness, cost, and cost-effectiveness of different testing strategies to identify infected animals at a single round of testing within dairy herds known to be MAP infected. A model was developed, taking account of both within-herd infection dynamics and test performance, to simulate the use of different tests at a single round of testing in a known infected herd. Model inputs included the number of animals at different stages of infection, the sensitivity and specificity of each test, and the costs of testing and culling. Testing strategies included either milk or serum ELISA alone or with fecal culture in series. Model outputs included effectiveness (detection fraction, the proportion of truly infected animals in the herd that are successfully detected by the testing strategy), cost, and cost-effectiveness (testing cost per true positive detected, total cost per true positive detected). Several assumptions were made: MAP was introduced with a single animal and no management interventions were implemented to limit within-herd transmission of MAP before this test. In medium herds, between 7 and 26% of infected animals are detected at a single round of testing, the former using the milk ELISA and fecal culture in series 5 yr after MAP introduction and the latter using fecal culture alone 15 yr after MAP introduction. The combined costs of testing and culling at a single round of testing increases with time since introduction of MAP infection, with culling costs being much greater than testing costs. The cost-effectiveness of testing varied by testing strategy. It was also greater at 5 yr, compared with 10 or 15 yr, since MAP introduction, highlighting the importance of early detection. Future work is needed to evaluate these testing strategies in subsequent rounds of testing as well as accounting for different herd dynamics and different levels of herd biocontainment.

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“…The primary economic models use the compartmental model to inform control measures from the standpoint of net present values at the herd level (Dressler et al, 2010;Cho et al, 2012Cho et al, , 2013. The optimization strategy depends on whether there is a relationship between Johne's and Crohn's disease in humans.…”

Section: Modeling Production and Health-johne's Disease (Example 2)mentioning

confidence: 99%

Progression to multi-scale models and the application to food system intervention strategies

Gröhn

2015

Preventive Veterinary Medicine

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Cost‐Effective Control Strategies for Johne's Disease in Dairy Herds

Cited by 26 publications

References 33 publications

The effects of progressing and nonprogressing Mycobacterium avium ssp. paratuberculosis infection on milk production in dairy cows

The effects of progressing and nonprogressing Mycobacterium avium ssp. paratuberculosis infection on milk production in dairy cows

Evaluation of testing strategies to identify infected animals at a single round of testing within dairy herds known to be infected with Mycobacterium avium ssp. paratuberculosis

Progression to multi-scale models and the application to food system intervention strategies

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