Abstract-A comprehensive research framework for a comparative analysis of candidate network architectures and protocols in the clean-slate design of next-generation optical access is proposed. The proposed research framework consists of a comparative analysis framework based on multivariate noninferiority testing and a notion of equivalent circuit rate taking into account user-perceived performances, and a virtual test bed providing a complete experimental platform for the comparative analysis. The capability of the research framework is demonstrated through numerical results from the study of the elasticity of hybrid TDM/WDM-PON based on tunable transceivers.Index Terms-Next-generation optical access, comparative analysis, equivalent circuit rate (ECR), statistical hypothesis testing, non-inferiority testing, quality of experience (QoE).