Cosmetic and pharmaceutical qualifications of Egyptian bentonite and its suitability as drug carrier for Praziquantel drug

Dardir, Fatma M.; Mohamed, Aya S.; Abukhadra, Mostafa R.; Ahmed, Ezzat A.; Soliman, Mamdouh F.

doi:10.1016/j.ejps.2018.01.041

Cited by 82 publications

(59 citation statements)

References 22 publications

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“…Bentonite ore has thus far been widely used as drilling mud, animal feed additive, adsorbent, and soil improvement agent [5][6][7][8]. Recently, nearly pure montmorillonite purified from bentonite has been extensively studied for its use in cosmetics, natural therapies, and pharmaceuticals [9][10][11][12], owing to its specific properties such as high swelling pressure, high cation exchange capacity, and high adsorption ability [13][14][15]. In pharmaceutical applications, montmorillonite was found to have an active role in dermatological protection and anti-inflammation, and as an antidiarrheal and antacid [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Effect of Nano-Montmorillonite on Osteoblast Differentiation, Mineral Density, and Osteoclast Differentiation in Bone Formation

Kim

Lee

et al. 2020

Nanomaterials

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Calcium-type montmorillonite, a phyllosilicate mineral, has diverse health benefits when introduced into the gastrointestinal tract or applied to the skin. However, the predominant use of this layered material has thus far been in traditional industries, despite its potential application in the pharmaceutical industry. We investigated the effects and mechanism of nano-montmorillonite (NM) on osteoblast and osteoclast differentiation in vivo and in vitro. We examined the osteogenic effects of NM with high calcium content (3.66 wt%) on alkaline phosphatase (ALP) activity, mineralization, bone microarchitecture, and expression level of osteoblast and osteoclast related genes in Ca-deficient ovariectomized (OVX) rats. Micro-computed tomography of OVX rats revealed that NM attenuated the low-Ca-associated changes in trabecular and cortical bone mineral density. It improved ALP activity and mineralization, as well as the expression of osteoblast and osteoclast differentiation associated genes. NM also activated the expression of runt-related transcription factor 2, osteocalcin, bone morphogenetic protein 2, and type 1 collagen via phosphorylated small mothers against decapentaplegic homolog 1/5/8 signaling. Further, NM repressed the expression of receptor activator for cathepsin K, nuclear factor kappa-B ligand and tartrate-resistant acid phosphatase. Therefore, NM inhibits osteoclastogenesis, stimulates osteoblastogenesis, and alleviates osteoporosis.

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Section: Introductionmentioning

confidence: 99%

Effect of Nano-Montmorillonite on Osteoblast Differentiation, Mineral Density, and Osteoclast Differentiation in Bone Formation

Kim

Lee

et al. 2020

Nanomaterials

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“…Such improvement in the OL loading capacities with testing higher concentrations of the OL drug was attributed to the expected increase in the driving forces of the present OL molecules, which promoted their adsorption by the EXK/CF active sites. 12 …”

Section: Resultsmentioning

confidence: 99%

“…The OL residual concentration was determined by an ultraviolet (UV) spectrophotometer after adjusting the λ max to 209 nm. The loading capacities were calculated from eq 6 ( 12 ) …”

Section: Experimental Workmentioning

confidence: 99%

“… 8 Clay minerals include several species of layered silicate minerals, and all of them have significant surface area, high natural reserves, low cost, excellent adsorption properties, nontoxicity, high biocompatibility values, and significant ion exchange properties. 11 , 12 Kaolinite and montmorillonite are the most studied clay minerals in industrial and medical applications. 13 Kaolinite is a hydrous form of aluminum silicate clay minerals of a 1:1 layered structure.…”

Section: Introductionmentioning

confidence: 99%

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Insight into the Loading and Release Properties of an Exfoliated Kaolinite/Cellulose Fiber (EXK/CF) Composite as a Carrier for Oxaliplatin Drug: Cytotoxicity and Release Kinetics

et al. 2020

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Kaolinite layers were exfoliated as single sheets and admixed with cellulose fibers, forming an advanced exfoliated kaolinite/cellulose fiber (EXK/CF) composite, which was characterized as a promising carrier for the oxaliplatin (OL) drug to induce safety as well as the therapeutic effect. The EXK/CF composite exhibited promising loading capacity and achieved an experimental value of 670 mg/g and an expected theoretical value of 704.4 mg/g. The loading behavior of OL using the EXK/CF composite followed the pseudo-first-order kinetic model and the Langmuir equilibrium model, achieving an adsorption energy of 7.7 kJ/mol. This suggested physisorption and homogeneous loading behavior of the OL molecules in a monolayer form. The release profile of OL from EXK/CF continued for about 100 h with maximum release percentages of 86.4 and 95.2% in the phosphate and acetate buffers, respectively. The determined diffusion exponent from the Korsmeyer–Peppas kinetic model suggested non-Fickian transport behavior of the OL molecules and releasing behavior controlled by erosion as well as diffusion mechanisms. Regarding the cytotoxic effect, the EXK/CF composite has a high safety impact on the normal colorectal cells (CCD-18Co) and higher toxic impacts on the colorectal cancer cell (HCT116) than the free oxaliplatin drug.

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“…The magmatic ilmenite deposit of Wadi Abu Ghalaga is the most famous deposit, which is mined and exported. Bentonite of Egypt is recorded in the Western and Eastern Desert [20][21][22] and Sinai [23]. The most important localities of Egyptian bentonite are located in the North-Western Desert, at south El-Hammam city and south/southwest Alamein area [21].…”

Section: Introductionmentioning

confidence: 99%

The physical properties of bitumen modified with ilmenite and bentonite nanoparticles

2020

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Using nanotechnology in asphalt paving has increased markedly to improve the asphalt characteristics and increase the road life, especially with the significant increase in traffic volumes. The present contribution evaluates the effects of ore nanoparticles namely ilmenite and bentonite on the engineering properties and performance of asphalt binder. The high-resolution transmission electron microscopy (HRTEM) micrograph was used to characterize the investigated nanomaterials. The nanoparticles were blended with asphalt binder with different percentages (0-5% for ilmenite and 0-10% for bentonite by weight of asphalt binder) to determine the appropriate mixing ratio that sustained the desired characteristics. Different tests were conducted to examine the properties of modified asphalt binder among which penetration, softening point, rotational viscosity, penetration index (PI) and ductility. The results of our study revealed an increase in softening point and rotational viscosity and decrease in binder penetration. Moreover, blending of variable amounts of nanomaterials with the asphalt binders has improved their physical properties compared with macroparticles blended and unmodified binders as indicated by the penetration index and ductility test. The most significant improvement in the modified binders was obtained by blending of 5% for two types of nanoparticles. Finally, the rut depth was measured by wheel track test for the modified asphalt mixture, with ilmenite and bentonite, to validate the obtained results. The results show that the engineering performance of asphalt produced from bitumen binder modified with nanoparticles is much better than conventional asphalt and such binder-modified asphalt is strongly recommended for use on site.

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Cosmetic and pharmaceutical qualifications of Egyptian bentonite and its suitability as drug carrier for Praziquantel drug

Cited by 82 publications

References 22 publications

Effect of Nano-Montmorillonite on Osteoblast Differentiation, Mineral Density, and Osteoclast Differentiation in Bone Formation

Effect of Nano-Montmorillonite on Osteoblast Differentiation, Mineral Density, and Osteoclast Differentiation in Bone Formation

Insight into the Loading and Release Properties of an Exfoliated Kaolinite/Cellulose Fiber (EXK/CF) Composite as a Carrier for Oxaliplatin Drug: Cytotoxicity and Release Kinetics

The physical properties of bitumen modified with ilmenite and bentonite nanoparticles

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