Cosavirus Infection in Persons with and without Gastroenteritis, Brazil

Stöcker, Andreas; Souza, Breno Frederico de Carvalho Dominguez; Ribeiro, Tereza Cristina Medrado; Netto, Eduardo Martins; Araujo, Luciana Gomes de; Corrêa, Jefferson Ivan; Almeida, Pedro Afonso de Oliveira; Mattos, Ângela Peixoto de; Ribeiro, Hugo da Costa; Pedral-Sampaio, Diana; Drosten, Christian; Drexler, Jan Felix

doi:10.3201/eid1804.111415

Cited by 51 publications

(41 citation statements)

References 13 publications

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“…Only on the basis of statistical analysis on clinical manifestation of cosavirus and its co-infection, we can conclude its significant association with gastroenteritis. Our data only supports the previous studies reported association of cosavirus in gastroenteritis from other countries 16,[28][29][30][31][32][33] . Previously cosavirus was only reported in stool samples of patient suspected for the acute flaccid paralysis (AFP) in India 34 .…”

Section: Table 3: Comparison Of Quantitative Clinical Parameters Betwsupporting

confidence: 50%

“…In 2012 Stocker et al reported presence for the cosavirus in Patients with gastroenteritis as well as in control group 30 . Very low prevalence (0.01% to 3.6%) of cosavirus was reported from other countries like in Japan, Thailand and Brazil 28,30,33 . In this study we found 3% prevalence of cosavirus.…”

Section: Table 3: Comparison Of Quantitative Clinical Parameters Betwmentioning

confidence: 99%

“…Cosavirus is reported globally in acute gastroenteritis cases, AFP cases, lung transplant recipient and in sewage water [28][29][30][31][32] , still its significant presence is not defined in gastroenteritis cases. In 2012 Stocker et al reported presence for the cosavirus in Patients with gastroenteritis as well as in control group 30 .…”

Section: Table 3: Comparison Of Quantitative Clinical Parameters Betwmentioning

confidence: 99%

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2016

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Viral gastroenteritis is one of the major causes of childhood mortality in India. About 30 to 50 % gastroenteritis caused by unknown etiological agents. This study was aimed to identify unknown RNA viral etiology and their clinical manifestation with pediatric acute gastroenteritis, conducted at tertiary care hospital of Uttar Pradesh, North India from July 2012 to December 2013. A total of 234 patients with their clinical profiling were enrolled in this study. Identification of viruses was performed by serological (ELISA for rotavirus) and molecular methods (PCR for astrovirus, norovirus and cosavirus). Quantitative and qualitative data analysis performed by Chi-square and student t-test. Total subjects positive for infection was 35%.Co-infection present in 21% cases. Rotavirus, astrovirus, norovirus and cosavirus were detected in 25%, 10%, 7% and 3% subjects respectively. Other than diarrhea, vomiting was a significant symptom (p=0.0002). Severity of diarrhea was more than vomiting with 5.5±2.7 vs. 3.3±2.6 episodes in 24 hrs. Mean duration of symptoms 3.7±9.1. Eighty percent virus positivity were below the age of 6 years (39.2 ±34.6, median=34 months) and 65% males were positive. This study defines the viral etiology and their clinical association with gastroenteritis. This is the first report of prevalence and co-infection of cosavirus in this region. The outcome of the study provides a baseline data which can be used to design and develop the preventive strategies against unknown etiologies like cosavirus.

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Section: Table 3: Comparison Of Quantitative Clinical Parameters Betwsupporting

confidence: 50%

Section: Table 3: Comparison Of Quantitative Clinical Parameters Betwmentioning

confidence: 99%

Section: Table 3: Comparison Of Quantitative Clinical Parameters Betwmentioning

confidence: 99%

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2016

IJPSR

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“…The presence of HCoSV genomes was first examined by TaqMan-based qPCR [11], using a LightCycler Ò 480 RealTime PCR Instrument II (Roche Diagnostics, Mannheim, Germany). The genome copy numbers of HCoSV were determined based on a standard curve prepared with tenfold serial dilutions of plasmid DNA containing the partial 5' UTR sequence of strain HCoSV-A1 (GenBank accession number: J438902).…”

Section: Introductionmentioning

confidence: 99%

Occurrence and genetic diversity of human cosavirus in influent and effluent of wastewater treatment plants in Arizona, United States

et al. 2015

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“…Human Enterovirus type C has also been identified among healthy children [32,33]. Human Cosavirus (for the common stool-associated Picornavirus) and human Salivirus (for the stool Aichi-like virus), which are not yet recognized as new species, have been reported in several studies in stool samples from healthy children [5,34,35,36,37,38]; however, an understanding of their pathogenicity is lacking because they can also be present in cases of gastroenteritis.…”

Section: Exploring the Viral Flora In Humansmentioning

confidence: 99%

Describing the Silent Human Virome with an Emphasis on Giant Viruses

et al. 2013

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Viruses are the most abundant obligate intracellular entities in our body. Until recently, they were only considered to be pathogens that caused a broad array of pathologies, ranging from mild disease to deaths in the most severe cases. However, recent advances in unbiased mass sequencing techniques as well as increasing epidemiological evidence have indicated that the human body is home to diverse viral species under non-pathological conditions. Despite these studies, the description of the presumably healthy viral flora, i.e. the normal human virome, is still in its infancy regarding viral composition and dynamics. This review summarizes our current knowledge of the human virome under non-pathological conditions.

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Cosavirus Infection in Persons with and without Gastroenteritis, Brazil

Cited by 51 publications

References 13 publications

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Occurrence and genetic diversity of human cosavirus in influent and effluent of wastewater treatment plants in Arizona, United States

Describing the Silent Human Virome with an Emphasis on Giant Viruses

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