Cortisone Treatment of Nephrosis

Arneil, Gavin C.; Wilson, H. E. C.

doi:10.1136/adc.27.134.322

Cited by 17 publications

(8 citation statements)

References 9 publications

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“…In many patients with the nephrotic syndrome, proteinuria diminished during or after treatment with corticotropin (ACTH) or Cortisone (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17). Further, in most patients so treated GFR increased (6)(7)(8)12).…”

mentioning

confidence: 99%

The Effect of Corticotropin (ACTH) on Glomerular Permeability to Albumin in Children with the Nephrotic Syndrome 12

Lauson¹,

Forman²,

McNamara³

et al. 1954

J. Clin. Invest.

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Present evidence indicates that proteinuria in patients with the nephrotic syndrome is the result of increased permeability of the glomerular capillary walls to proteins, particularly to albumin (1, 2). A rough indication of the permeability to albumin, relative to permeability to water, is provided by the ratio of the concentration of albumin in glomerular fluid to that in plasma. Assuming that no albumin is excreted by the tubules, the rate of albumin excretion (in mg. per min.) divided by the rate of glomerular filtration of water (GFR, in ml. per min.) represents the lowest possible concentration of albumin in glomerular fluid (in mg. per ml.) ; if some albumin is reabsorbed by the tubules, as seems likely, the actual concentration of albumin in glomerular fluid would be greater than this calculated value. If it is accepted that the clearance of inulin (CIN) is equivalent to GFR in children with the nephrotic syndrome (3), it follows that the renal clearance of albumin (CALB) divided by CIN, i.e., CALB/CIN, represents the minimum ratio of the albumin concentration in glomerular fluid to that in plasma. Chinard, Lauson, and Eder (4) showed that in patients with the nephrotic syndrome the renal clearance of the blue dye, T-1824 (CT_1824), was somewhat less than but approximately proportional to CALB. It would appear, therefore, that where large changes in permeability are expected CT_1824should be a satisfactory substitute for CALB. The

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mentioning

confidence: 99%

The Effect of Corticotropin (ACTH) on Glomerular Permeability to Albumin in Children with the Nephrotic Syndrome 12

Lauson¹,

Forman²,

McNamara³

et al. 1954

J. Clin. Invest.

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“…(adrenocorticotrophin) at this hospital. The results of cortisone treatment have been reported previously (Arneil and Wilson, 1952) and corresponding findings for A.C.T.H. are now given and the value of the two hormones compared.…”

mentioning

confidence: 70%

“…The cortisone-treated cases previously reported (Arneil and Wilson, 1952) have since been augmented in numbers, and 15 courses of this hormone have now been given to nine cases of nephrosis. These 15 courses provoked diuresis on 10 occasions in this small series, whereas A.C.T.H.…”

Section: Treatmentmentioning

confidence: 99%

“…The finding of an excess of antidiuretic substance in the systemic blood of nephrotic patients (Barlow, 1952) encouraged us in this speculation. The investigation of this problem leading to the identification and analysis of a peptide in nephrotic urine, closely resembling posterior pituitary hormone, has been published elsewhere (Arneil and Wilson, 1953).…”

Section: Treatmentmentioning

confidence: 99%

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A.C.T.H in Nephrosis

Arneil¹,

Wilson²

1953

Archives of Disease in Childhood

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“…Gavin CA y Wilson EH, trataron a seis pacientes con altas dosis de cortisona (de 100 a 300 mg/día) por 5 días y el resultado fue la remisión de la proteinuria. 3 En 1978, se publica uno de los primeros estudios multicéntricos prospectivos en nefrología pediátrica con la incorporación de 24 centros de América del Norte, Europa y Asia.…”

unclassified

Consenso de tratamiento del síndrome nefrótico en la infancia

2014

Arch Argent Pediat

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Cortisone Treatment of Nephrosis

Cited by 17 publications

References 9 publications

The Effect of Corticotropin (ACTH) on Glomerular Permeability to Albumin in Children with the Nephrotic Syndrome 12

The Effect of Corticotropin (ACTH) on Glomerular Permeability to Albumin in Children with the Nephrotic Syndrome 12

A.C.T.H in Nephrosis

Consenso de tratamiento del síndrome nefrótico en la infancia

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