Cortisone Treatment of Bell's Palsy

Taverner, D.

doi:10.1016/s0140-6736(54)90608-x

Cited by 58 publications

(15 citation statements)

References 8 publications

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“…The two class I studies 10,11 and one class II study 12 did not show significantly better outcomes in steroid-treated patients. However, these studies were insufficiently powered to exclude a clinically important effect from steroids.…”

Section: Figure Relative Rates Of Good Outcomes (Rectangles) With 95mentioning

confidence: 85%

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Practice parameter: Steroids, acyclovir, and surgery for Bell’s palsy (an evidence-based review) [RETIRED]

Grogan

Gronseth²

2001

Neurology

190

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Article abstract-Objective: To determine the effectiveness of steroids, acyclovir, and surgical facial nerve decompression in Bell's palsy. Methods: The authors identified articles by searching MEDLINE and selected those that prospectively compared outcomes in patients treated with steroids, acyclovir, or surgery with patients not receiving these modalities. The authors graded the quality of each study (class I to IV) using a standard classification-of-evidence scheme. They compared the proportion of patients recovering facial function in the treated group to the proportion of patients recovering facial function in the control group. Results: The authors identified no adequately powered class I studies for any treatment modality. The pooled results of two class I and two class II studies showed significantly better facial outcomes in steroid-treated patients compared with non-steroid-treated patients (relative rate good outcome 1.16, 95% CI 1.05 to 1.29). One class II study demonstrated a significant benefit from acyclovir in combination with prednisone compared with prednisone alone (relative rate good outcome 1.22, 95% CI

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Section: Figure Relative Rates Of Good Outcomes (Rectangles) With 95mentioning

confidence: 85%

“…With the exception of one study 11 that used hydrocortisone, authors used oral prednisone or prednisolone. Authors from another study 12 did not specify the corticosteroid used, but we assumed it was prednisone because the dosage was similar to other studies using this medication.…”

Section: Discussionmentioning

confidence: 99%

Practice parameter: Steroids, acyclovir, and surgery for Bell’s palsy (an evidence-based review) [RETIRED]

Grogan

Gronseth²

2001

Neurology

190

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“…Taverner in 1954 was the first to design a controlled treatment trial of steroids but unfortunately the number of patients was too small to permit a signifcant statistical evaluation (Taverner 1954). …”

Section: Bell's Palsymentioning

confidence: 99%

Role of Corticosteroids in Oral Lesions

Mehdipour¹,

Zenouz²

2012

State of the Art of Therapeutic Endocrinology

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“…Table 1 summarizes these studies and includes 2 of the studies reviewed in the original guideline that attained a grading of Class II or better. 16,17 Only Class I and Class II studies are discussed further. The 2 Class I studies 8,11 randomized patients to steroids vs placebo and described concealed allocation.…”

mentioning

confidence: 99%

“…The 3 Class II studies [15][16][17] did not describe concealed allocation. These studies enrolled fewer than 100 patients each and described complete follow-up and masked outcome assessment.…”

mentioning

confidence: 99%