Role of Corticosteroids in Oral Lesions

Mehdipour, Masoumeh; Zenouz, Ali Taghavi

doi:10.5772/50287

Cited by 9 publications

(12 citation statements)

References 145 publications

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“…The role of systemic corticosteroids in SJS-TEN is controversial. l2, 10 The lesions may be treated with a short course of systemic glucocorticosteroid in patients without significant contraindications to their use. 10 The patient was referred to oral medicine specialist to evaluate and manage the oral manifestation and noted that the oral lesions have not giving significant reaction to the systemic corticosteroid.…”

Section: Discussionmentioning

confidence: 99%

The Importance of Accurate Anamnesis in Determining Suspected Drugs Causing of Oral Manifestation of Stevens Johnson Syndrome-Toxic Epidermal Necrolysis (Case Report)

Selvia

Wardhany

2017

UIP HEATH MED

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Introduction: Stevens - Johnson Syndrome (SJS) and Toxic epidermal necrolysis (TEN) are drug hypersensitivity life-threatening disease that involve skin and mucous membrane. Oral manifestation occurs in almost all the patients of SJS-TEN.Case report: A 52-years-old SJS-TEN female patient was referred from department of dermatology and venereology of RSCM hospital, Jakarta to the department of oral medicine, because of the painful ulcers in the mouth and difficulty to eat. Severe loss of integrity lesions was found in lips and oral mucosa. The causing drugs cannot be identified earlier because of challenging condition during anamnesis. The leading clue of suspected causative drugs was conducted by oral medicine specialist with in depth anamnesis of thorough patients’ medical history. Allergic test after six-week period after the patient first visit shows positive result of carbamazepine and amitriptyline hypersensitivity.Discussion: The delayed in determining causing drugs in this case were because of several causes, especially lack of information gain during anamnesis. In the condition when the operator cannot obtain sufficient information due to patient condition, it was very important to have an excellent communication in the collaborating medical team and patient family as well as constantly obtaining new important information during the ongoing treatment. Since the appropriate and successful treatment was depending in determining an exact cause, the anamnesis plays a critical role in this case.Conclusion: Accurate anamnesis by operator was an important part regarding the successful management of patient with SJS-TEN since the disease has an enormous impact in patient’s quality of life.

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Section: Discussionmentioning

confidence: 99%

The Importance of Accurate Anamnesis in Determining Suspected Drugs Causing of Oral Manifestation of Stevens Johnson Syndrome-Toxic Epidermal Necrolysis (Case Report)

Selvia

Wardhany

2017

UIP HEATH MED

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“…Systemically, prednisone may be used or dexamethasone pulse therapy may be advocated to avoid long-term use of systemic steroids. [ 17 ]…”

Section: E Rythema M Ultiformementioning

confidence: 99%

“…Topical betamethasone or clobetasol is indicated. [ 17 ] Systemically, prednisone (10–20 mg/day) or on alternate days may be required. Intralesional triamcinolone may also be useful in specific cases.…”

Section: Upus E Rythematosusmentioning

confidence: 99%

Systemic and topical steroids in the management of oral mucosal lesions

et al. 2017

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From the time of its introduction in the 1040s, glucocorticoids have provided a panacea for many diseases. The therapeutic benefit of corticosteroids lies in their anti-inflammatory and immunosuppressive properties which makes them highly effective in the management of oral mucosal lesions. This article aims to present to the clinician, the plethora of options available as steroid therapy and enables one to choose based on the underlying disease and the properties of the drug.

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“…Topical steroid such as mometasone furoate microemulsion shows a significant reduction in pain in erosiveulcerative oral lichen planus 18 .The treatment of choice for mild mucous membrane pemphigoid appearing in the mouth include corticosteroid mouthwashes and ointments. Various studies showed the efficacy of topical corticosteroids for symptomatic relief in recurrent aphthous stomatitis, oral lichen planus, erythema multiforme, pemphigus, mucous membrane pemphigoid, bullous pemphigoid, systemic lupus erythematosis, post herpetic neuralgia, facial pain and temporomandibular joint disorders 19 . Hydrocortisone hemisuccinate (as pellets of 2.…”

Section: Topical Corticosteroidsmentioning

confidence: 99%

“…1% of the steroid)are the drugs most commonly adopted for local oral application in RAS .An aqueous suspension of triamcinolone acetonide 0. 1% was used as an oral rinse in the treatment of 46 patients with symptomatic oral lichen planus (Vincent 1990) 19 . A highpotency topical corticosteroid (0.05% clobetasol propionate in Orabase; Colgate, New York, NY) was used for controlling the symptomatology of mucoceles 20 .…”

Section: Topical Corticosteroidsmentioning

confidence: 99%

Ağrı Kesici Olarak Topikal İlaçlar

Srinivasan¹,

Shenai²,

Chatra³

et al. 2015

Arşiv Kaynak Tarama Dergisi

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Topical therapy helps patients with oral and perioral pain problems such as ulcers, burning mouth syndrome, temporomandibular disorders, neuromas, neuropathies and neuralgias. Topical drugs used in the field of dentistry are topical anaesthetics, topical analgesics, topical antibiotics and topical corticosteroids. It provides symptomatic/curative effect. Topical drugs are easy to apply, avoids hepatic first pass metabolism and more sites specific. But it can only be used for medications that require low plasma concentrations to achieve a therapeutic effect. Key words: Topical therapy, topical analgesics, topical antibiotics, topical anesthetics, topical corticosteroids, drugs. ÖZET

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Role of Corticosteroids in Oral Lesions

Cited by 9 publications

References 145 publications

The Importance of Accurate Anamnesis in Determining Suspected Drugs Causing of Oral Manifestation of Stevens Johnson Syndrome-Toxic Epidermal Necrolysis (Case Report)

The Importance of Accurate Anamnesis in Determining Suspected Drugs Causing of Oral Manifestation of Stevens Johnson Syndrome-Toxic Epidermal Necrolysis (Case Report)

Systemic and topical steroids in the management of oral mucosal lesions

Ağrı Kesici Olarak Topikal İlaçlar

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