Cortisone in the Immediate Therapy of Apoplectic Stroke

Cardiac Pharmacology

“…However, some authors find that, while f3-blocking agents have little influence on the electrocardiographic pat tern typical of coronary insufficiency (159,160,164), the combination of propranolol and isosorbid dinitrate, apart from alleviating pain and improv ing exercise capacity, notably modifies the ischemic electrocardiographic pattern of selected patients with severe and refractory forms of angina ( 177). This combination of propranolol and isosorbid dinitrate produced persistent relief of symptoms in 109 of 115 patients including some with re fractory angina (178). In twelve other cases of angina evaluated in a blind crossover study the combination of the two drugs produced a greater overall improvement than either drug alone (179).…”

The Prevention of Ischaemic Heart Disease

“…These observations have suggested that stress and physical inactivity may be precipitating factors. Occupational stress is more than four times as common in those with IHD as in healthy controls (Russek and Zohman 1958). Friedman et al (1958) have shown that stress is accompanied by an increased serum cholesterol in accountants at the end of the financial year.…”

Capillary Fragility in Older People. The Evaluation of Bio‐flavonoid Therapy†

“…According to a statement in the Journal of the American Medical Association, "certainly they are contraindicated in cases of cerebral hemorrhage, but even in cases in which typical cerebral thrombosis appears to be present, the use of anticoagulants has led to fatal intracerebral hemorrhage" (55). Russek et al (56) recommend the use of cortisone in apoplectic stroke, and reported favorable results in 15 cases. Although immediate cortisone therapy may benefit apoplectic patients by improving their emotional and mental status, it has no effect on patients with cerebral hemorrhage, according to these investigators.…”