Capillary Fragility in Older People. The Evaluation of Bio‐flavonoid Therapy†

Treatment of Diabetic Retinopathy With Estrogens

“…Drug therapy. Criticism directed toward drug therapy in the management of diabetic retinopathy is justifiable, in view of the initial, but transient, enthusiasm for the host of agents that have failed to live up to the claims made for them (3–10). Furthermore, one has to consider wide variations in the rate of resorption of intraocular hemorrhages.…”

The Little Stroke

“…Excessive cold or heat may also result in increased capillary fragility, as reported by Zaprometov (33). Increased capillary fragility is a frequent phenomenon in aging persons, as shown by Perry and Linden (34), Martin (35), Sokoloff et al (36) and others. The frequency of stroke among the older population, particularly among those with chronic diseases, and the fact that the stroke often occurs soon after a viral or bacterial infection strongly point to capillary injury as the major factor in causing little stroke.…”

“…The hypertensive and diabetic patients showed the highest degree of capillary fragility with the number of petechiae rising to as high as 48–50 per unit area. Since it has been reported (36) that bioflavonoids have a beneficial influence on increased capillary fragility in older people, the petechial index was rechecked regularly every six months both in the patients treated with C.V.P. and in the control group.…”

Dietary factors affecting blood spot incidence and changes in the vascular system of the hen / by John Wilburn Merkley.

“…hov/ever, it is thcu.ght to be related to capillary fr:3gi.lity by many au/chors. Seme reports have shown that hesperidin ancT closoly related compound.^have a therapeutic effect in cases of capil.lary fragility of n'-aircmals (Scarborough and Edin, 1938;Sokoloff et al, 1957). Nalbandov and Card (1947), found that the addition of rutin and vitamin C to the ration did not reduce the incidence of blood and meat spots.…”