Cortisone-Ascorbic Acid Interaction and the Pathogenesis of Amyloidosis : Mechanism of Action of Cortisone on Mesenchymal Tissue

The Relation between Amyloid and Ageing in Comparative Pathology

“…Such progress is illustrated by the recognition of chronic rheumatoid arthritis as a condition which prediposes to amyloidosis. While quite recently this relation was only hesitantly suggested (Trasoff et al, 1944), it is now increasingly recognized [Gedda, 1955) and even plays an important role in modern theories on the mechanism of amyloid formation (Teilum, 1952). Thus the range of conditions which are known as possible causes of "secondary" amyloidosis is gradually widening.…”

“…Additional treatment is then superimposed, and the depressing or enhancing effect upon amyloid induction is observed. In this way, an amyloidogenic effect was found to be exercised by increased room temperature (Perasalo, 1949), cortisone or ACTH (Teilum, 1952), nitrogen mustard (Teilum, 1954), vitamin C deficiency and TSH (Uotila et al, 1955).…”

“…It has been concluded that any agent disturbing the collodial stability of serum proteins may cause protein breakdown leading to disturbed antigenantibody relations and amyloid formation (Letterer, 1934). Recently Letterer's theory on antigen-antibody relations in connection with amyloid is being reformulated in terms of exhaustion of antibody forming potencies of mesenchymal (reticulo-endothelial) cells (Gôssner et al, 1951 ;Latvalahti, 1953) or of a perversion or suppres sion of the normal metabolism of plasma cells ( Teilum, 1952( Teilum, , 1954. However this may be, for the present purpose it suffices to note that in mice such a diversity of procedures leads to identical or closely related amyloidotic conditions.…”

Amyloid enhancing factor activity is associated with ubiquitin

“…AA amyloid deposition occurs in two steps (Teilum 1952, Brandwein et al 1985a& 1985b, Sipe et al 1978, Sipe at al. 1986).…”

Experimental Amyloidosis and the Effect of Cortisone Treatment

“…In view of the effect of cortisone treatment on the RE-system in relation to immunological mechanisms [8,11,24], the present study deals with the effect of this hormone on experimental amyloidosis as well as a morpholog ical study of the spleen and liver before the amyloid deposits are developed.…”