Cortisone and Mortality in Mouse Typhoid. II. Effect of Environmental Temperature.

Abstract

479ing resistance to infection. Because these small doses were shown to be non-toxic to the normal animal, it would seem that cortisone has some specific detrimental effect in mouse typhoid.Summary. Cortisone, administered in single injections ranging from 0.25 to 5 mg, markedly decreased resistance of mice to S. typhimurium. Cortisone had the greatest effect on resistance when administered within 2 days before or after typhoid inoculation. Subcutaneous injections of two other steroids, progesterone and deso'xycorticosterone acetate, in dosage range of 0.1 to 10 mg, had no effect on mortality in mouse typhoid. 1. Kass, E. H., and Finland, M., Ann. Rev. Microb i d , 1953, v7, 361. 2. Shwartzman, G., editor, The Eflect of ACTH and Cortisone upon Infection and Resistance, Columbia Univ. Press, N. Y., 1953, 204 pp.