Cortisol levels in fingernails, neurocognitive performance and clinical variables in euthymic bipolar I disorder

Herane-Vives, Andrés; Cleare, Anthony J.; Chang, Chin‐Kuo; Angel, Valeria de; Papadopoulos, Andrew; Fischer, Susanne; Halari, Rozmin; Cheung, Eric Yat Wo; Young, Allan H.

doi:10.1080/15622975.2017.1298838

Cited by 10 publications

(11 citation statements)

References 78 publications

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“…Finally, the use of hair specimens to measure chronic cortisol concentrations is a relatively new tool, and there remain uncertainties regarding the effects of many potential confounding factors . As a result, other biological sources, such as fingernail specimens, might ultimately be better suited to measure chronic cortisol levels in affective disorders .…”

Section: Discussionmentioning

confidence: 99%

Short‐term and long‐term measures of cortisol in saliva and hair in atypical and non‐atypical depression

Herane-Vives

Angel

Papadopoulos

et al. 2018

Acta Psychiatr Scand

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Section: Discussionmentioning

confidence: 99%

Short‐term and long‐term measures of cortisol in saliva and hair in atypical and non‐atypical depression

Herane-Vives

Angel

Papadopoulos

et al. 2018

Acta Psychiatr Scand

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“…More studies are needed in order to corroborate our findings, as well as the exploration of other biological sources with the potential to measure cortisol levels over a longerterm period, such as fingernails. 55,56 Indeed, by using fingernail specimens, we recently found increased fingernail cortisol concentration in out-patients with moderate MDEs in comparison with controls. This difference was, indeed, mainly driven by melancholic symptoms.…”

Section: Cortisol In Out-patients With Melancholic Depressionmentioning

confidence: 94%

Comparison of short-term (saliva) and long-term (hair) cortisol levels in out-patients with melancholic and non-melancholic major depression

et al. 2020

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Background Major depressive episodes (MDEs) show diverse cortisol level alterations. Heterogeneity in symptom profiles, symptom severity and cortisol specimens may explain these heterogeneous results. Less severely ill out-patients with a non-melancholic MDE (NM-MDE) may have a variation in the rhythm of cortisol secretion rather than in its concentration. Method Cortisol measures were taken (a) over a short-term period (12 h) by measuring daily salivary output using the area under the curve with respect to the ground (AUCg) and (b) over a long-term period (3 months) in hair. Additionally, cortisol reactivity measures in saliva – the cortisol awakening response and the 30 min delta cortisol secretion after awakening (DELTA) – were investigated in 19 patients with a melancholic MDE (M-MDE) and 52 with a NM-MDE, and in 40 matched controls who were recruited from the UK and Chile. Depression severity scores were correlated with different cortisol measures. Results The NM-MDE group showed a decreased AUCg in comparison with controls (P = 0.02), but normal cortisol reactivity and long-term cortisol levels. The M-MDE group did not exhibit any significant cortisol alterations nor an association with depression severity scores. Higher Hamilton Rating Scale for Depression score was linked with decreased hair cortisol concentration (HCC, P = 0.05) and higher DELTA (P = 0.04) in NM-MDEs, whereas decreased HCC was the sole alteration associated with out-patients with severe M-MDEs. Conclusions The contrasting short- and long-term cortisol output results are compatible with an alteration in the rhythm of cortisol secretion in NM-MDEs. This alteration may consist of large and/or intense episodes of hypercortisolaemia in moderate NM-MDEs and frequent, but brief and sharp early-morning DELTAs in its severe form. These changes may reflect the effects of environmental factors or episodes of nocturnal hypercortisolaemia that were not measured by the short-term samples used in this study.

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“…Fingernail cortisol extraction method widely used in previous studies was adopted in this study. 19 , 21 , 23 , 27 , 30 Each fingernail sample was transferred into a 15 mL Falcon tube (BD Biosciences, Franklin Lakes, NJ, USA). Then, 5 mL of isopropanol was added.…”

Section: Methodsmentioning

confidence: 99%

“… 25 In the same year, Higashi et al confirmed that there was little difference in fingernail cortisol between the right and left hands, and fingernail analysis using either hand looked promising for the evaluation of cortisol level in the body. 26 Currently, fingernail cortisol measurement has been applied in patients with euthymic bipolar I disorder and cancer, 27 , 28 as well as in individuals experiencing a major depressive episode. 29 In comparison with saliva, blood, or urine as samples to assess chronic stress, fingernail cortisol could be a convenient and accurate measure.…”

Section: Introductionmentioning

confidence: 99%

Associations of perceived stress with the present and subsequent cortisol levels in fingernails among medical students: a prospective pilot study

Wu¹,

Zhou²,

Xu³

et al. 2018

PRBM

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PurposeCortisol in fingernails could retrospectively reflect cumulative stress over a long period. However, the association between fingernail cortisol and perceived stress needs to be validated. This exploratory study aimed to investigate the associations of perceived stress with the present and subsequent cortisol levels in fingernails of the subjective stress measurement among medical students.MethodsStudents were recruited from a medical university in Shenyang, China. The final sample consisted of 51 students (16 men, 35 women). On the Day 30 of our data and fingernail collection procedure, the 10-item Perceived Stress Scale was used to measure perceived stress. Fingernail samples were collected twice, on Days 15 (denoted as FD15) and 45 (denoted as FD45) of the procedure, and participants were asked to grow fingernails for 15 days in each collection. Cortisol was determined by an enzyme immunoassay method using the ELISA kit. Multiple linear regression was performed to examine the association between perceived stress and cortisol level. The Bonferroni correction was made for multiple comparisons.ResultsThe level of cortisol was 5.65 pg/mg (SD =1.88) for FD15 and 5.41 pg/mg (SD =1.63) for FD45. Perceived stress was not associated with the cortisol level of FD15 (β=−0.014, P=0.924), but it was significantly and positively associated with the cortisol level of FD45 (β=0.436, P=0.003), which remained significant after Bonferroni correction. The associations between fingernail cortisol and demographic variables (gender, age, BMI, and physical activity) were not significant.ConclusionThis study was the first to investigate fingernail cortisol in China. Perceived stress was positively associated with the subsequent cortisol levels in fingernails, but not the present. The findings suggested that fingernail cortisol could indicate stress exposure in the past. Furthermore, a simple and easy self-reported measure could reflect cumulative stress as measured by fingernail cortisol.

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Cortisol levels in fingernails, neurocognitive performance and clinical variables in euthymic bipolar I disorder

Cited by 10 publications

References 78 publications

Short‐term and long‐term measures of cortisol in saliva and hair in atypical and non‐atypical depression

Short‐term and long‐term measures of cortisol in saliva and hair in atypical and non‐atypical depression

Comparison of short-term (saliva) and long-term (hair) cortisol levels in out-patients with melancholic and non-melancholic major depression

Associations of perceived stress with the present and subsequent cortisol levels in fingernails among medical students: a prospective pilot study

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