Cortisol, DHEAS and aging: Resistance to cortisol suppression in frail institutionalized elderly

Carvalhaes-Neto, Nelson; Huayllas, Martha Katherine Paniagua; Ramos, Luiz Roberto; Cendoroglo, M. S.; Kater, Cláudio E.

doi:10.1007/bf03345117

Cited by 26 publications

(14 citation statements)

References 53 publications

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“…Elevated levels of stress (and of cortisol) during pregnancy have been associated with preterm labor, low infant birth weight and Apgar scores, and increased use of neonatal intensive care unit services (21)(22)(23). Epidemiological data indicate an inverse relationship between serum DHEA and DHEAS concentrations and the frequency of cardiovascular diseases, immune function, progression of HIV infection, Alzheimer's disease, and progression of age-related diseases (25)(26)(27). Elevated levels of DHEAS are found in patients with adrenal tumors and congenital adrenal hyperplasia, and slightly elevated levels are found in patients with polycystic ovary syndrome (28,29).…”

Section: Discussionmentioning

confidence: 99%

Steroid hormone levels in pregnancy and 1 year postpartum using isotope dilution tandem mass spectrometry

Soldin

Guo

Weiderpass

et al. 2005

Fertility and Sterility

140

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Objective-To establish normal, trimester-specific reference intervals for serum 17β-estradiol, progesterone (P), 17α-hydroxyprogesterone, cortisol, 11-deoxycortisol, androstenedione, DHEA, and DHEAS, measured simultaneously using isotope dilution tandem mass spectrometry. Design-Sequential cohort study.Patient(s)-Healthy women undergoing a normal pregnancy (age, 25-38 years; mean, 30 years) attending a prenatal well clinic at gestation weeks 12, 22, and 32 and approximately 1 year postpartum.Main Outcome Measure(s)-Trimester-specific reference intervals of endogenous steroid hormones analyzed using an isotope dilution tandem mass spectrometer equipped with an atmospheric pressure photoionization source with deuterium-labeled internal standards.Result(s)-Serum estradiol, P, 17α-hydroxyprogesterone, and 11-deoxycortisol increased throughout pregnancy; cortisol increased up to the second trimester and then remained steady, while androstenedione increased by 80 percent by gestation week 12, then remained constant. Serum DHEA-S decreased by 50% by the third trimester. Normal pregnancy depends on pronounced adaptations in pregnancy-related hormone concentrations, characterized by elevated levels of several circulating steroid hormones, which normally increase with the progression of pregnancy (1-6). Endogenous steroid hormone exposure during pregnancy has been of interest in studies of duration of gestation, fetal size, twin pregnancies, control of labor, nausea and vomiting in pregnancy, pregnancyinduced hypertension, and other disease states (5-9). The studies have generally produced weak and inconsistent findings because the hormone levels were either not available or lacked specificity or because surrogate measures of exposure to altered steroid hormone levels were often used to estimate these hormones. Conclusion(s)- NIH Public AccessSteroid hormones are derived from cholesterol. Binding proteins facilitate their transport and increase their half-life but limit their entry into target cells, thereby regulating their biological activity. Binding proteins make precise determination of serum steroid hormone concentrations difficult by interfering with different steroid hormones immunoassays (IAs). Furthermore, the lack of specificity of IAs due to cross reactivity with structurally related molecules is a well-known phenomenon (10-12).In contrast, isotope dilution liquid chromatography-tandem mass spectrometry (LC/MS/MS) is a specific detection method that allows the quantification of the analyte of interest. It also allows for a simpler approach to sample preparation without employing lengthy and timeconsuming extraction and sample derivatization steps. This has been reported in a previous publication, and steroid hormone analysis using isotope dilution LC/MS/MS was compared with the analysis of the same samples using IA techniques (14). Generally, tandem mass spectrometry provides lower values than IA, no doubt because of improved specificity.The reasons for the improved specificity in our tandem mass sp...

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Section: Discussionmentioning

confidence: 99%

Steroid hormone levels in pregnancy and 1 year postpartum using isotope dilution tandem mass spectrometry

Soldin

Guo

Weiderpass

et al. 2005

Fertility and Sterility

140

View full text Add to dashboard Cite

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“…A large and growing body of evidence links activity of the neuroendocrine, cardiovascular, and immune system parameters that we have noted to show substantial change with age and stress experience to levels of cognitive and physical functioning in later life. For example, indicators of low anabolic to high catabolic hormone activity (e.g., low levels of DHEA, high levels of cortisol, impaired glucocorticoid feedback regulation, a high cortisol to DHEA ratio) have been linked to the development and/or severity of cognitive impairments (see Ferrari et al, 2000;Pedersen, Wan, & Mattson, 2001;Polleri, Gianelli, & Murialdo, 2002, for reviews) and physical frailty and/or disability (Carvalhaes-Neto, Huayllas, Ramos, Cendoroglo, & Kater, 2003;Ershler & Keller, 2000;Roubenoff, 2003;Valenti et al, 2004). Similarly, proinfl ammatory biomarkers, such as IL-6 and CRP, are predictive of the development and/or progression of cognitive impairment (Godbout & Johnson, 2009;Weaver et al, 2002;Yaffe et al, 2003) and physical frailty (Ferrucci et al, 1999;Taaffe, Harris, Ferrucci, Rowe, & Seeman, 2000;Walston et al, 2002).…”

Section: Cognitive and Physical Functioningmentioning

confidence: 96%

Stress and Aging: A Biological Double Jeopardy?

Gruenewald¹,

Seeman²

2010

annu rev gerontol geriatr

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Chronic stress may take its toll on the body at any period in the life course, but age may be linked to characteristics of stressor exposure and response, as well as underlying biological vulnerabilities, which modulate the effects of stressor experience on biological well-being. In this review, we fi rst address age-related patterns of stressor exposure and response, highlighting commonly experienced stressors in older adults and characteristics of stressor appraisal and coping in later life. We then review patterns of biological functioning associated with chronic stress experience and aging in an effort to highlight the biological commonalities associated with both conditions. We conclude with an examination of the idea that the biological changes typically observed with advancing age may render older adults more susceptible to negative biological and health consequences of chronic stress experience.

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“…That is, although DHEA(S) concentrations tend to decline under such conditions, cortisol concentrations generally either increase or do not change. Since anabolic and catabolic hormones regulate each other and may produce "net effects", the ratio of their levels represents an important addition to measures of either one independently (Carvalhaes-Neto et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Effects of dehydroepiandrosterone supplementation during stressful military training: A randomized, controlled, double-blind field study

Taylor

Padilla

Stanfill

et al. 2011

Stress

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Dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) are anabolic prehormones involved in the synthesis of testosterone. Both have been shown to exert neuroprotective effects during stress. In this randomized, controlled, double-blind field study, we examined the effects of a 12-day DHEA regimen on stress indices in military men undergoing survival training. Forty-eight men were randomized to either a DHEA treatment group or placebo control group. The treatment group received 50 mg of oral DHEA supplementation daily for 5 days during classroom training followed by 7 days of 75 mg during stressful field operations. Control subjects received identical placebo pills. Salivary assays (DHEA[S], testosterone, and cortisol) were conducted at four time points: distal pre-stress (T1), proximal pre-stress (T2), mock-captivity stress (T3), and 24 h recovery (T4). Subjective distress was also assessed at T1, T3, and T4. As expected, DHEA treatment resulted in higher salivary concentrations of DHEA and DHEAS during daily living, mock-captivity stress, and recovery. Similar patterns were observed for salivary markers of anabolic balance: DHEA/cortisol, DHEAS/cortisol, and testosterone/cortisol concentration ratios. Despite notable time effects, no group differences emerged for subjective distress. A brief, low dose DHEA regimen yielded large increases in salivary DHEA(S) concentrations and enhanced anabolic balance throughout sustained military stress. These physiological changes did not extrapolate to subjective distress.

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Cortisol, DHEAS and aging: Resistance to cortisol suppression in frail institutionalized elderly

Cited by 26 publications

References 53 publications

Steroid hormone levels in pregnancy and 1 year postpartum using isotope dilution tandem mass spectrometry

Steroid hormone levels in pregnancy and 1 year postpartum using isotope dilution tandem mass spectrometry

Stress and Aging: A Biological Double Jeopardy?

Effects of dehydroepiandrosterone supplementation during stressful military training: A randomized, controlled, double-blind field study

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