Cortisol and its effects on cognitive function in a sample of Egyptian school-aged children with attention-deficit hyperactivity disorder

Ibrahim, Omneya; El-lithy, Wafaa; Elmoez, Khaled Abd

doi:10.4103/1110-1105.180270

Cited by 3 publications

(1 citation statement)

References 24 publications

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“…As we expected, only adolescents with high, but not intermediate, levels of hyperactivity/inattention symptoms since early childhood showed lower morning cortisol, compared to those with low and decreasing levels. This finding is consistent with previous evidence of attenuated morning cortisol profiles in adolescents diagnosed with ADHD (Angeli et al, 2018; El-Moez et al, 2016; Fortier et al, 2013; Imeraj et al, 2012; Isaksson et al, 2012). Hypocortisolism in the general child population can be considered a marker of allostatic load.…”

Section: Discussionsupporting

confidence: 93%

Childhood Trajectories of Hyperactivity/Inattention Symptoms and Diurnal Cortisol in Middle Adolescence: Results from a UK Birth Cohort

Ji¹,

Flouri²,

Papachristou³

et al. 2021

J Atten Disord

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Objective Children with attention-deficit/hyperactivity disorder (ADHD) show hypoactivity of the hypothalamic-pituitary-adrenal (HPA) axis. Whether the association between hyperactivity/inattention symptoms with HPA axis dysfunction holds in the general child population too is not clear. Method We assessed associations between longitudinal trajectories of hyperactivity/inattention symptoms during ages 4 to 13 years and basal cortisol profiles at age 15 in a British general population cohort. Results Adolescents with persistently high levels of hyperactivity/inattention symptoms since childhood showed lower total morning cortisol and a smaller diurnal decline, even after adjusting for confounders. No associations were found between any of the symptom trajectories and cortisol awakening response, diurnal slope or daily output of cortisol. Conclusion This study provides evidence for hypocortisolism among adolescents with chronic hyperactivity/inattention symptoms in the general population.

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