The role of inflammatory markers and cortisol in the association between early social cognition abilities and later internalising or externalising problems: Evidence from a UK birth cohort

Inflammatory Markers in Children and Adolescents with Functional Somatic Disorders: A Systematic Review

“…A skewing of the immune system with altered cytokine production has been suggested to be linked to long-term stress exposure causing an activation of the hypothalamicpituitary-adrenal (HPA) axis and the inflammatory system. In a state of chronic stress, prolonged activation of the HPA axis with elevated production of the stress hormone cortisol can cause impairment of the immune system's sensitivity to cortisol, resulting in elevated levels of inflammatory markers [45]. The influence of chronic stress on the HPA axis may change over time, transitioning from heightened to diminished activity, ultimately leading to inadequate regulation of inflammation [46].…”

The role of inflammation in the effects of peer victimisation and stressful life events on mental health in childhood

“…Inflammation was measured by interleukin 6 (IL-6) and C-reactive protein (CRP) levels at age 9, obtained from blood samples during clinic visits (see also Ji et al, 2022 ). Blood samples were collected from non-fasting participants before being immediately spun and frozen at −80 °C, with no evidence of freeze-thaw cycles during storage.…”