Corticotropin-releasing hormone downregulates IL-10 production by adaptive forkhead box protein 3–negative regulatory T cells in patients with atopic dermatitis

Oh, Sang Ho; Park, Chang Ook; Wu, Wen‐guey; Kim, Ji Young; Jin, Songqing; Byamba, Dashlkhumbe; Bae, Bumhan; Noh, Seongmin; Lim, Beom Jin; Noh, Ji Yeon; Lee, Kwang Hoon

doi:10.1016/j.jaci.2011.09.008

Cited by 35 publications

(23 citation statements)

References 60 publications

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“…Emotional anxieties such as stress compromise the immunological changes of AD and neuroendocrine function and can become aggravating factors of AD (Raap, Werfel, Jaeger, & SchmidOtt, 2003), and in the cases of participants affected with AD, there are changes involving decreasing Th1/Th2 ratio and the number of NK cells (Pallanti, Lotti, & Urpe, 2005). Corticotrophin-releasing hormone, a stress hormone, reduces functions of acquired T cells releasing IL-10 among AD patients to further worsen AD (Oh et al, 2012), and a vicious cycle, in which deteriorated AD induces a new stress, is repeated. Accordingly, stress needs to be managed first in order to reduce prevalence rates of AD, and complementary adjustment aimed to reduce stress caused by AD is required.…”

Section: Discussionmentioning

confidence: 99%

Prevalence Rate and Factors Associated with Atopic Dermatitis among Korean Middle School Students

Oak

Lee

2012

J Korean Acad Nurs

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Purpose: The purpose of this study was to verify prevalence rates of atopic dermatitis (AD) in middle school students in Korea and to define AD and associated factors. Methods: This study was conducted using secondary analysis of raw data from the 'The 6th Korean National Adolescent Health Behavior Survey, 2010' conducted by the Korea Centers for Disease Control. The participants were 37,570 students. General characteristics and health behavior-related characteristics were analyzed using descriptive statistics, χ 2 -test and logistic regression analysis. Results: Results are as follows. 1. There were 8,494 middle school students (22.6%), who had been diagnosed with AD during the last 12 months. 2. Factors associated with AD in middle school students were gender (p< .001), grade level (p= .001), father's education (p< .001), mother's education (p= .032), regular dietary habits (breakfasts, p= .025; lunches; p= .003), stress (p< .001), recognition of subjective awareness of one's health conditions (p< .001), hand washing before meals at school (p= .013), and cessation education for both smoking (p= .002) and alcohol (p= .031). Conclusion: Results of the study indicate that in order to alleviate AD symptoms in these students, there is a need to develop nursing interventions and education programs taking into consideration these variables and verifying the effects of interventions and programs.

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Section: Discussionmentioning

confidence: 99%

Prevalence Rate and Factors Associated with Atopic Dermatitis among Korean Middle School Students

Oak

Lee

2012

J Korean Acad Nurs

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“…106 However, these effects could be counterbalanced by IL-10, which controls dendritic cell-induced T-cell reactivity in the skin. 107,108 Corticotropin-releasing hormone, which downregulates IL-10 production by adaptive forkhead box protein 3-negative regulatory T cells, 109 has been recently found to have altered expression in patients with AD. 110 Although AD is known as a T H 2-and T H 22-mediated inflammatory skin disease, and psoriasis is known as a T H 1/T H 17-mediated skin disease, 111 there might be AD subsets that do not follow this rule.…”

Section: Immunologic Responsesmentioning

confidence: 99%

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2012

Sicherer

Leung

2013

Journal of Allergy and Clinical Immunology

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This review highlights some of the research advances in anaphylaxis; hypersensitivity reactions to foods, drugs, and insects; and allergic skin diseases that were reported in the Journal in 2012. Studies support an increase in peanut allergy prevalence in children and exposure to the antibacterial agent triclosan and having filaggrin (FLG) loss-of-function mutations as risk factors for food sensitization. The role of specific foods in causing eosinophilic esophagitis is elucidated by several studies, and microRNA analysis is identified as a possible noninvasive disease biomarker. Studies on food allergy diagnosis emphasize the utility of component testing and the possibility of improved diagnosis through stepped approaches, epitope-binding analysis, and bioinformatics. Treatment studies of food allergy show promise for oral immunotherapy, but tolerance induction remains elusive, and additional therapies are under study. Studies on anaphylaxis suggest an important role for platelet-activating factor and its relationship to the need for prompt treatment with epinephrine. Insights on the pathophysiology and diagnosis of non-IgE-mediated drug allergy are offered, with novel data regarding the interaction of drugs with HLA molecules. Numerous studies support influenza vaccination of persons with egg allergy using modest precautions. Evidence continues to mount that there is cross-talk between skin barrier defects and immune responses in patients with atopic dermatitis. Augmentation of the skin barrier with reduction in skin inflammatory responses will likely lead to the most effective intervention in patients with this common skin disease.

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“…In this issue of the Journal, 2 articles shed new light on the role of IL-10 in CHS, a model for allergic contact dermatitis, and in patients with atopic dermatitis (AD), respectively. 6,7 Girard-Madoux et al 6 generated mice harboring a cell-specific deletion of IL-10Ra in all CD11c 1 cells (termed DC-IL10R 2/2 mice) to study the role of IL-10 signaling on CD11c 1 cells during CHS. Of note, CD11c is most prominent on DCs and Langerhans cells.…”

mentioning

confidence: 99%

The suppressive role of IL-10 in contact and atopic dermatitis

Boyman

Werfel

Akdiş

2012

Journal of Allergy and Clinical Immunology

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Corticotropin-releasing hormone downregulates IL-10 production by adaptive forkhead box protein 3–negative regulatory T cells in patients with atopic dermatitis

Cited by 35 publications

References 60 publications

Prevalence Rate and Factors Associated with Atopic Dermatitis among Korean Middle School Students

Prevalence Rate and Factors Associated with Atopic Dermatitis among Korean Middle School Students

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2012

The suppressive role of IL-10 in contact and atopic dermatitis

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