The suppressive role of IL-10 in contact and atopic dermatitis

Boyman, Onur; Werfel, Thomas; Akdiş, Cezmi A.

doi:10.1016/j.jaci.2011.10.046

Cited by 24 publications

(12 citation statements)

References 11 publications

(16 reference statements)

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“…MEKS did not affect the expression of IL-10, however, DEX significantly reduced the expression levels of all cytokines examined in the present study, including IL-10, which has a suppressive role in CD and atopic dermatitis (20). Treatment with DEX also led to a significant reduction in the spleen/body weight ratio when compared with the CTL and the NOR groups, which is indicative of an immune reaction.…”

contrasting

confidence: 52%

Anti-inflammatory activity of Kochia scoparia fruit on contact dermatitis in mice

Ryu

Han

et al. 2015

Molecular Medicine Reports

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Abstract. The mature fruit of Kochia scoparia (L.) Schrad. is widely administered in China and Korea as a medicinal herb for treatment of skin diseases, diabetes mellitus and rheumatoid arthritis. The present study investigated the effects of methanol extracts of K. scoparia dried fruit (MEKS) on ear swelling, histopathological changes (such as epidermal acanthosis, spongiosis and immune cell infiltration) and cytokine production in 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis mice. Topical application of MEKS inhibited DNFB-induced ear thickness and weight increases, as well as DNFB-induced epidermal acanthosis, spongiosis and immune cell infiltration. In addition, treatment with MEKS significantly decreased the levels of tumor necrosis factor-α, interferon-γ and monocyte chemotactic protein-1 in inflamed tissues. These data indicate that the mature fruit of K. scoparia has the potential to be administered for the treatment of inflammatory skin diseases and that the anti-inflammatory action of K. scoparia is involved in the inhibition of type 1 T helper cell skewing reactions.

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contrasting

confidence: 52%

Anti-inflammatory activity of Kochia scoparia fruit on contact dermatitis in mice

Ryu

Han

et al. 2015

Molecular Medicine Reports

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“…16 It seems that in both patients with atopic dermatitis and those with allergic contact dermatitis, IL-17, IL-22, and IL-10 display inflammatory, tissue-protective, immunoregulatory roles, and sometimes all 3 can exist in the same biopsy specimen, demonstrating the complexity of the inflammation. 168 …”

Section: Role Of Il-22 In Patients With Allergic Diseasementioning

confidence: 99%

TH17 and TH22 cells: A confusion of antimicrobial response with tissue inflammation versus protection

Akdiş

Palomares

Veen

et al. 2012

Journal of Allergy and Clinical Immunology

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164

118

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“…106 However, these effects could be counterbalanced by IL-10, which controls dendritic cell-induced T-cell reactivity in the skin. 107,108 Corticotropin-releasing hormone, which downregulates IL-10 production by adaptive forkhead box protein 3-negative regulatory T cells, 109 has been recently found to have altered expression in patients with AD. 110 Although AD is known as a T H 2-and T H 22-mediated inflammatory skin disease, and psoriasis is known as a T H 1/T H 17-mediated skin disease, 111 there might be AD subsets that do not follow this rule.…”

Section: Immunologic Responsesmentioning

confidence: 99%

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2012

Sicherer

Leung

2013

Journal of Allergy and Clinical Immunology

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This review highlights some of the research advances in anaphylaxis; hypersensitivity reactions to foods, drugs, and insects; and allergic skin diseases that were reported in the Journal in 2012. Studies support an increase in peanut allergy prevalence in children and exposure to the antibacterial agent triclosan and having filaggrin (FLG) loss-of-function mutations as risk factors for food sensitization. The role of specific foods in causing eosinophilic esophagitis is elucidated by several studies, and microRNA analysis is identified as a possible noninvasive disease biomarker. Studies on food allergy diagnosis emphasize the utility of component testing and the possibility of improved diagnosis through stepped approaches, epitope-binding analysis, and bioinformatics. Treatment studies of food allergy show promise for oral immunotherapy, but tolerance induction remains elusive, and additional therapies are under study. Studies on anaphylaxis suggest an important role for platelet-activating factor and its relationship to the need for prompt treatment with epinephrine. Insights on the pathophysiology and diagnosis of non-IgE-mediated drug allergy are offered, with novel data regarding the interaction of drugs with HLA molecules. Numerous studies support influenza vaccination of persons with egg allergy using modest precautions. Evidence continues to mount that there is cross-talk between skin barrier defects and immune responses in patients with atopic dermatitis. Augmentation of the skin barrier with reduction in skin inflammatory responses will likely lead to the most effective intervention in patients with this common skin disease.

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The suppressive role of IL-10 in contact and atopic dermatitis

Cited by 24 publications

References 11 publications

Anti-inflammatory activity of Kochia scoparia fruit on contact dermatitis in mice

Anti-inflammatory activity of Kochia scoparia fruit on contact dermatitis in mice

TH17 and TH22 cells: A confusion of antimicrobial response with tissue inflammation versus protection

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2012

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