Corticotropin-releasing Factor Mediates the Antinociceptive Action of Nitrous Oxide in Rats

Sawamura, Shigehito; Obara, Masahiko; Takeda, Kenji; Maze, Mervyn; Hanaoka, Kazuo

doi:10.1097/00000542-200309000-00028

Cited by 36 publications

(19 citation statements)

References 30 publications

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“…However, the mechanisms by which this peptide acts are still unclear [22]. Previous studies have suggested that the analgesic effect of CRF on somatic pain sensitivity may be mediated by both opioid and non-opioid mechanisms [23,24]. For example, a previous report [25] demonstrated that CRF administered i.c.v in anesthetized rats has an analgesic effect on sensitivity to somatic pain (caused by electrical current).…”

Section: Discussionmentioning

confidence: 99%

Activation of the corticotropin-releasing factor receptor from the basolateral or central amygdala modulates nociception in guinea pigs

Donatti¹,

Leite–Panissi²

2013

ABB

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Corticotropin-releasing factor (CRF) is a peptide that is released from the hypothalamus into widespread areas of the brain. Evidence has suggested that CRF is involved as a neuromodulator outside of the hypothalamic-pituitary-adrenal axis, playing an important role in fear, anxiety, depression and pain modulation. Our previous report demonstrated that CRF receptor activation in basolateral (BLA) or central nuclei of the amygdala (CeA) produces innate fear in guinea pigs. Inhibition of these receptors via administration of α-helical CRF 9-41 (a nonspecific antagonist) into the CeA or BLA decreased innate fear behavior [1]. Additionally, there is strong evidence that emotional behavior and nociception can be modulated simultaneously. The present study was conducted to investigate the involvement of the CRF receptors of the BLA or CeA in nociception in guinea pigs. Guinea pigs were treated with CRF and α-helical CRF9-41 in three different doses or injected with α-helical CRF 9-41 preceded by CRF into the BLA or CeA, and they were evaluated using the hot plate test. Our findings indicated that activation of CRF receptors in the BLA and in the CeA promoted antinociception, and this effect was reversed by preadministration of α-helical CRF 9-41 in the same area. The treatment with α-helical CRF 9-41 per se into the BLA and CeA did not alter nociception. Thus, nociception modulation occurs in a phasic manner, whereas defensive behavior can occur tonically because the α-helical CRF 9-41 did not cause any modification on the index of analgesia in the hot plate test but did reduce innate fear behavior [1].

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Section: Discussionmentioning

confidence: 99%

Activation of the corticotropin-releasing factor receptor from the basolateral or central amygdala modulates nociception in guinea pigs

Donatti¹,

Leite–Panissi²

2013

ABB

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“…While nitrous oxide is often used for pain relief in normal vaginal delivery and dental procedures, during surgery it is combined with anaesthetic agents. It has been reported in experimental animal studies that the supraspinal opioid receptors are activated through the corticotropine releasing factor of N 2 O [13]. Thus, an interaction occurs between N 2 O and exogenous opioids.…”

Section: Discussionmentioning

confidence: 99%

The Effects Of Nitrous Oxide On Postoperative Pain, Nausea Vomiting and Intraoperative Haemodynamics in Robotic Gynecologic Surgery

Yanli¹

2017

SDRP-JAS

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BACKGROUND n recent years there has been an increase in gynaecological operations performed with robotic surgery. In these procedures, nitrous oxide(N 2 O) or air are used together with inhalation anaesthestics. In this study we aimed to compare the effects of O 2 /N 2 O or O 2 /Air on postoperative pain, nausea vomiting (PONV) and intraoperative thermodynamics in robotic surgery. METHODSAged 28-71 years, classified ASA I-II, 58 patients were separated into 2 groups. Following induction, anaesthesia was maintained O 2 /Air (Group A) or O 2 /N 2 O (Group N) with sevoflurane. Heart rate (HR), mean arterial pressure (MAP), Central Venous Pressure (CVP), end tidal carbon dioxide (ETCO 2 ), peripheral oxygen saturation (SpO 2 ), Aldrete recovery score (ARS), postoperative nausea and vomiting (PONV) and visual analog scale (VAS) were recorded during the operation and postoperative period. RESULTSThe VAS values were higher in Group N at 5th min and higher in Group A at 150th min (p<0.05). In the intragroup analysis, VAS values were significantly lower at 120th, 150th, 180th min compared with 5th, 15th, 30th and 60th min in Group N (p<0.05). In Group A, the values at 15th, 30th min was significantly higher than 60th, 120th and 180th min (p<0.05). Intraoperative haemodynamic parameters (HR, MAP, CVP) were similar in two groups (p>0.05). Intragroup analysis of PONV values were significantly lower at 150th and 180th min compared with both 5th and 30th min in Group N and significantly higher at 5th min compared with 180th min in GroupA(p<0.05). CONCLUSIONWith regard to acute postoperative analgesia we could not find any significant difference between N 2 O and air. Further clinical studies are required to investigate this subject in respect of differences (at 5th min and at 150th min) in the VAS scores.

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“…27 Increased corticotropin-releasing hormone production has also been described in the mechanism of nitrous oxide's antinociceptive action. 28 Nitrous oxide, however, is also a noncompetitive inhibitor of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors 29 and has the capability to activate 2-pore-domain potassium channels, which when activated, hyperpolarize neurons away from their firing threshold. 30 These actions may account for reported neuroprotective effects of nitrous oxide.…”

Section: Discussionmentioning

confidence: 99%

Seizures Temporally Associated With Nitrous Oxide Administration for Pediatric Procedural Sedation

Zier

Doescher

2010

J Child Neurol

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Nitrous oxide is an inhaled agent commonly used by dental staff to provide anxiolysis and analgesia for dental procedures and by anesthesia personnel as an adjunct to more potent general anesthetic gases. More recently, nitrous oxide has been used to provide sedation/analgesia for a variety of medical procedures in children outside of the operating room, including lumbar puncture, laceration repair, fracture reduction, and urologic imaging. We report 3 cases of clinical seizure activity associated with nitrous oxide administration for pediatric procedural sedation. Although temporally related, no causality is established. Review of the medical and dental literature confirm the rarity of these events.

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Corticotropin-releasing Factor Mediates the Antinociceptive Action of Nitrous Oxide in Rats

Abstract: Nitrous oxide activates the CRF system in the brain, which results in stimulation of noradrenergic neurons in the locus ceruleus and its consequent antinociceptive effect.

Cited by 36 publications

References 30 publications

Activation of the corticotropin-releasing factor receptor from the basolateral or central amygdala modulates nociception in guinea pigs

Activation of the corticotropin-releasing factor receptor from the basolateral or central amygdala modulates nociception in guinea pigs

The Effects Of Nitrous Oxide On Postoperative Pain, Nausea Vomiting and Intraoperative Haemodynamics in Robotic Gynecologic Surgery

Seizures Temporally Associated With Nitrous Oxide Administration for Pediatric Procedural Sedation

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