Corticosterone increases spike-wave discharges in a dose- and time-dependent manner in WAG/Rij rats

Schridde, Ulrich; Luijtelaar, Gilles van

doi:10.1016/j.pbb.2004.04.012

Cited by 48 publications

(27 citation statements)

References 44 publications

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“…Notably, seizure activity in these baboons followed a circadian rhythm, with maximal seizure activity correlating with maximal urine cortisol levels (Ehlers and Killam, 1979). Moreover, the WAG/ Rij rats, an absence epilepsy model, show a rapid, albeit transient increase in the number of absence seizures in response to the administration of CORT (Schridde and van Luijtelaar, 2004). In contrast, administration of CORT to absence seizure-prone DBA/2J mice decreased the number of spontaneous spike and wave discharges observed (Capasso et al, 1994).…”

Section: Effects Of Corticosterone On Seizuresmentioning

confidence: 90%

Stress and Epilepsy: Multiple Models, Multiple Outcomes

Sawyer

Escayg

2010

Journal of Clinical Neurophysiology

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Human studies show a link between stress and epilepsy, with stress causing an increase in seizure frequency and severity in patients with epilepsy. Many different animal model systems have been used to better understand this connection and the possible mechanisms involved. This review highlights the results of such studies relating stress and seizure susceptibility, with a focus on the hypothalamic-pituitary-adrenal axis and its relationship to seizure generation. The effects of hypothalamic-pituitary-adrenal axis mediators, acute stress, chronic stress, and early life stress on the seizure phenotype are summarized. Results suggest that stress has both anticonvulsive and proconvulsive properties, depending on the animal strain and the stress/seizure induction paradigm used. Attempts to interpret the stress-epilepsy literature must take these variables into account. The growing availability of genetically modified mice that carry either human epilepsy mutations or mutations in stress pathway genes now provide the opportunity to examine the relationship between stress and epilepsy more directly.

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Section: Effects Of Corticosterone On Seizuresmentioning

confidence: 90%

Stress and Epilepsy: Multiple Models, Multiple Outcomes

Sawyer

Escayg

2010

Journal of Clinical Neurophysiology

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“…The similarity between the circadian rhythms of seizures and cortisol could be explained by the proconvulsive effects of stress hormones, that were suggested by human studies reporting stress as a seizure precipitant (reviewed by van Campen et al [9]) and animal studies showing that stress hormones, such as CRH [46][47][48][49][50] and corticosteroids [51][52][53][54], can influence neuronal excitability and seizure threshold.…”

Section: Discussionmentioning

confidence: 99%

Seizure occurrence and the circadian rhythm of cortisol: a systematic review

Campen

Valentijn

Jansen

et al. 2015

Epilepsy & Behavior

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“…CORT also has been implicated in aggravation of seizure activity in this model (Schridde and van Luijtelaar 2004a). Administration of corticosterone led to an increase in spike wave discharges in WAG/Rij rats (Schridde and van Luijtelaar 2004a).…”

Section: Generalised Epilepsiesmentioning

confidence: 94%

“…Administration of corticosterone led to an increase in spike wave discharges in WAG/Rij rats (Schridde and van Luijtelaar 2004a). Electrophysiological changes due to early life manipulations, though not conclusively established from the available literature, have important potential implications for generalised epilepsies too and further studies are clearly warranted.…”

Section: Generalised Epilepsiesmentioning

confidence: 95%

Electrophysiological insights into the enduring effects of early life stress on the brain

et al. 2010

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Increasing evidence links exposure to stress early in life to long-term alterations in brain function, which in turn have been linked to a range of psychiatric and neurological disorders in humans. Electrophysiological approaches to studying these causal pathways have been relatively underexploited. Effects of early life stress on neuronal electrophysiological properties offer a set of potential mechanisms for these susceptibilities, notably in the case of epilepsy. Thus, we review experimental evidence for altered cellular and circuit electrophysiology resulting from exposure to early life stress. Much of this work focuses on limbic long-term potentiation, but other studies address alterations in electrophysiological properties of ion channels, neurotransmitter systems, and the autonomic nervous system. We discuss mechanisms which may mediate these effects, including influences of early life stress on key components of brain synaptic transmission, particularly glutamate, GABA and 5-HT receptors, and influences on neuroplasticity (primarily neurogenesis and synaptic density) and on neuronal network activity. The existing literature, although small, provides strong evidence that early life stress induces enduring, often robust effects on a range of electrophysiological properties, suggesting further study of enduring effects of early life stress employing electrophysiological methods and concepts will be productive in illuminating disease pathophysiology.

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Corticosterone increases spike-wave discharges in a dose- and time-dependent manner in WAG/Rij rats

Cited by 48 publications

References 44 publications

Stress and Epilepsy: Multiple Models, Multiple Outcomes

Stress and Epilepsy: Multiple Models, Multiple Outcomes

Seizure occurrence and the circadian rhythm of cortisol: a systematic review

Electrophysiological insights into the enduring effects of early life stress on the brain

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