Corticosterone-attenuating and anxiolytic properties of mecamylamine in the rat

Newman, Mary B.; Nazian, Stanley J.; Sanberg, Paul R.; Diamond, David M.; Shytle, R. Douglas

doi:10.1016/s0278-5846(00)00178-0

Cited by 45 publications

(32 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Intra-CeA administration of the nicotinic receptor antagonist mecamylamine produced clear anxiolyticlike effects in the plus maze, without any effect on locomotor activity. This is in agreement with other investigators who found that mecamylamine may have anxiolytic properties [58] and reduces tension and anxiety in patients with Tourette syndrome [59] . Thus, there may be a natural cholinergic-nicotinic pathway in the CeA blockade of which may induce anxiolytic responses.…”

Section: Discussionsupporting

confidence: 93%

Effect of Intra-Amygdala Injection of Nicotine and GABA Receptor Agents on Anxiety-Like Behaviour in Rats

Zarrindast¹,

Solati²,

Oryan

et al. 2008

Pharmacology

View full text Add to dashboard Cite

There is evidence that both cholinergic and GABAergic systems are involved in the neurobiology of anxiety. In the present study, we investigated the effects and interaction of nicotinic and GABAergic systems in the central amygdala of rats, using the elevated plus maze test of anxiety. Bilateral administration of nicotine (1 and 2 µg/rat; 1 µl/rat; 0.5 µl/rat in each side) into the central amygdala (intra-CeA) induced an anxiogenic-like effect, shown by specific decreases in the percentage of open-arm time (%OAT) and percentage of open arm entries (%OAE). Intra-CeA injection of mecamylamine, a selective nicotine acetylcholine receptor antagonist (20, 30 and 50 ng/rat; 1 µl/rat; 0.5 µl/rat in each side) produced significant anxiolytic-like behaviour. The intra-CeA injection of the GABA_A receptor agonist muscimol (0.25, 0.5 and 0.75 µg/rat; 1 µl/rat; 0.5 µl/rat in each side) decreased %OAT and %OAE, indicating anxiogenic-like behaviour. However, intra-CeA administration of the GABA_A receptor antagonist bicuculline (0.25, 0.5 and 1 µg/rat; 1 µl/rat; 0.5 µl/rat in each side) produced significant anxiolytic-like behaviour. Nicotine in a subeffective dose (0.25 µg/rat) when co-administered with muscimol did not significantly increase the anxiety behaviour. An effective dose of nicotine (2 µg/rat) in combination with bicuculline (0.25, 0.5 and 1 µg/rat) had no interaction on %OAT, %OAE and locomotor activity. It can be concluded that in the central amygdala, the GABAergic system is not involved in the anxiogenic response to nicotine.

show abstract

Section: Discussionsupporting

confidence: 93%

Effect of Intra-Amygdala Injection of Nicotine and GABA Receptor Agents on Anxiety-Like Behaviour in Rats

Zarrindast¹,

Solati²,

Oryan

et al. 2008

Pharmacology

View full text Add to dashboard Cite

show abstract

“…First, the enhanced reactivity of the HPA axis provides clues for neuropsychopharmacotherapy. For example, it has been shown that mecamylamine blocks the neuroendocrine effects of acetylcholine, thereby stimulating the HPA axis and ostensibly targeting the underlying stress and anxiety associated with TS (Newman et al, 2001;Sanberg et al, 1998;Silver et al, 2000). In addition, the observed relationship between tic performance and reduced cortisol in patients suggests that behavioral therapy which aims to redirect rather than suppress motor and vocal tics may be preferred (Evers & van de Wetering, 1994).…”

Section: Discussionmentioning

confidence: 99%

Examining cortisol rhythmicity and responsivity to stress in children with Tourette syndrome

Corbett

Mendoza

Baym

et al. 2008

Psychoneuroendocrinology

View full text Add to dashboard Cite

show abstract

“…In adult rats, mecamylamine generally has been reported to have anxiolytic-like effects at low doses (0.1, 0.3, & 1.0 mg/kg), with no effects on anxiety-like behavior at a higher dose (3.0 mg/kg) (Newman et al, 2002;Newman et al, 2001). Perhaps the 1.0 mg/kg dose of mecamylamine used in the present study was not anxiolytic in adult sham animals due to the surgical manipulation necessary to implant the minipumps, given that the elevated plus maze has been shown to be quite sensitive to prior perturbation (Doremus et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Withdrawal from chronic nicotine in adolescent and adult rats

Wilmouth

Spear

2006

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

The purpose of the present experiment is to assess potential differences in nicotine withdrawal in both adolescent and adult rats. Nicotine dependence was induced via osmotic minipump in adolescent rats (releasing 22.2 mg/kg/day on Postnatal Day 28) and adults (release rate of 18.4 mg/kg/day on Postnatal Day 60); differential initial release rates were used across age to compensate for the more rapid weight gain of adolescence. On Day 7 of nicotine exposure, withdrawal was induced via the administration of a nicotinic antagonist, mecamylamine (1.0 mg/kg i.p.), and withdrawal-induced anxiogenesis assessed on the elevated plus maze. On Days 1 and 4 after pump removal, animals were examined for startle responses and prepulse inhibition in an acoustic startle chamber. Adult animals exhibited a nicotine withdrawal-induced increase in anxiety, while adolescents did not. One day following the removal of minipumps, only nicotine dependent adolescent animals exhibited a disruption in prepulse inhibition. Nicotine withdrawal failed to produce an alteration in acoustic startle response in either group. Together these data suggest that ontogenic differences in nicotine withdrawal are dependent on the withdrawal measure examined, with adolescents being less sensitive than adults to anxiety-like symptoms, while being more sensitive to withdrawal-induced cognitive disruption.Despite the overall decrease in adolescent tobacco use that has occurred in the past 10 years, the prevalence of use among teens is still quite high, with 50% of 12 th graders reporting trying smoking and 23% reporting smoking within the last 30 days in 2005 (Johnston, et al

show abstract

Corticosterone-attenuating and anxiolytic properties of mecamylamine in the rat

Cited by 45 publications

References 29 publications

Effect of Intra-Amygdala Injection of Nicotine and GABA Receptor Agents on Anxiety-Like Behaviour in Rats

Effect of Intra-Amygdala Injection of Nicotine and GABA Receptor Agents on Anxiety-Like Behaviour in Rats

Examining cortisol rhythmicity and responsivity to stress in children with Tourette syndrome

Withdrawal from chronic nicotine in adolescent and adult rats

Contact Info

Product

Resources

About