Examining cortisol rhythmicity and responsivity to stress in children with Tourette syndrome

Corbett, Blythe A.; Mendoza, Sally P.; Baym, Carol L.; Bunge, Silvia A.; Levine, Seymour

doi:10.1016/j.psyneuen.2008.03.014

Cited by 77 publications

(83 citation statements)

References 58 publications

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“…For example, a series of adult TD patients were found to have elevated levels of cerebrospinal fluid (CSF) norepinephrine and to have excreted high levels of urinary norepinephrine in response to the stress associated with a lumbar puncture (Chappell et al 1994). These elevated levels of CSF norepinephrine may also contribute to the elevation in CSF corticotropin-releasing factor and peripheral cortisol levels seen in some TD patients (Chappell et al 1996;Corbett et al 2008). …”

Section: Noradrenergic Systemmentioning

confidence: 99%

Neurobiological Substrates of Tourette's Disorder

Leckman

Bloch

Smith³

et al. 2010

Journal of Child and Adolescent Psychopharmacology

169

126

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Objective: This article reviews the available scientific literature concerning the neurobiological substrates of Tourette's disorder (TD). Methods: The electronic databases of PubMed, ScienceDirect, and PsycINFO were searched for relevant studies using relevant search terms. Results: Neuropathological as well as structural and functional neuroimaging studies of TD implicate not only the sensorimotor corticostriatal circuit, but also the limbic and associative circuits as well. Preliminary evidence also points to abnormalities in the frontoparietal network that is thought to maintain adaptive online control. Evidence supporting abnormalities in dopaminergic and noradrenergic neurotransmission remains strong, although the precise mechanisms remain the subject of speculation. Conclusion: Structural and functional abnormalities in multiple parallel corticostriatal circuits may underlie the behavioral manifestations of TD and related neuropsychiatric disorders over the course of development. Further longitudinal research is needed to elucidate these neurobiological substrates.

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Section: Noradrenergic Systemmentioning

confidence: 99%

Neurobiological Substrates of Tourette's Disorder

Leckman

Bloch

Smith³

et al. 2010

Journal of Child and Adolescent Psychopharmacology

169

126

View full text Add to dashboard Cite

show abstract

“…Clinical observations as well as studies of TD and early-onset OCD have consistently suggested that these disorders are sensitive to psychosocial stress (Bornstein et al 1990;Chappell et al 1994;Charmandari et al 2003;Hoekstra et al 2004). For example, a number of reports documented an abnormal response to stress in TD patients (Chappell et al 1996;Lin et al 2007;Corbett et al 2008). Recently, Lin et al (2009) monitored 45 children with tic disorder and/or OCD and 41 matched healthy control subjects over a 2-year period for the level of psychosocial stress.…”

Section: The Role Of Psychosocial Stressmentioning

confidence: 99%

The Immunobiology of Tourette's Disorder, Pediatric Autoimmune Neuropsychiatric Disorders Associated withStreptococcus, and Related Disorders: A Way Forward

Murphy

Kurlan

Leckman

2010

Journal of Child and Adolescent Psychopharmacology

143

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Obsessive-compulsive disorder (OCD) and related conditions including Tourette's disorder (TD) are chronic, relapsing disorders of unknown etiology associated with marked impairment and disability. Associated immune dysfunction has been reported and debated in the literature since the late 80s. The immunologic culprit receiving the most interest has been Group A Streptococcus (GAS), which began to receive attention as a potential cause of neuropsychiatric symptoms, following the investigation of the symptoms reported in Sydenham's chorea (SC) and rheumatic fever, such as motor tics, vocal tics, and both obsessive-compulsive and attention deficit/hyperactivity symptoms. Young children have been described as having a sudden onset of these neuropsychiatric symptoms temporally associated with GAS, but without supporting evidence of rheumatic fever. This presentation of OCD and tics has been termed pediatric autoimmune neuropsychiatric disorders associated with Streptococcus (PANDAS). Of note, SC, OCD, and TD often begin in early childhood and share common anatomic areas-the basal ganglia of the brain and the related cortical and thalamic sites-adding support to the possibility that these disorders might share a common immunologic and/or genetic vulnerability. Relevant manuscripts were identified through searches of the PsycINFO and MedLine databases using the following keywords: OCD, immune, PANDAS, Sydenham chorea, Tourette's disorder Group A Streptococcus. Articles were also identified through reference lists from research articles and other materials on childhood OCD, PANDAS, and TD between 1966 and December 2010. Considering the overlap of clinical and neuroanatomic findings among these disorders, this review explores evidence regarding the immunobiology as well as the relevant clinical and therapeutic aspects of TD, OCD, and PANDAS.

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“…Furthermore, evening cortisol values were negatively correlated with overall tic severity 1 . This is relevant to our cases, as Weiner et al revealed a significant decrease in nocturnal cortisol production after use of fluticasone in patients with mild-to-moderate asthma who had not used inhaled corticosteroids (ICS) for at least three months 2 .…”

Section: Discussionmentioning

confidence: 94%

“…Corbett et al studied salivary cortisol levels in children 7-13 years with TS compared to healthy controls and discovered that the TS group had significantly lower evening cortisol levels compared to the control group 1 . Furthermore, evening cortisol values were negatively correlated with overall tic severity 1 .…”

Section: Discussionmentioning

confidence: 99%