Corticosteroid Replacement Therapy

Abstract

The advent of synthetic corticosteroids in the 20th century provided a vital breakthrough in the management of adrenal insufficiency. In this chapter we review the main indications and guidance for appropriate hormone replacement and also look into the management of therapy during special circumstances. For decades hydrocortisone has remained the cornerstone for glucocorticoid replacement but we explore the alternatives including recently introduced modified-release drug preparations and the future treatment considerations currently undergoing research and pre-clinical trials.

The potential hepato-renal toxic effects of glutamate and sulfite sodium in broiler chickens

“…However, the examination of the histological structure of the liver revealed no damage suggesting that ALP content increased without reaching the critical level indicating the hepatic cells damages, the results presented in the present study revealed that feeding broiler chickens with MSG improve growth performance with no detrimental effect on the histological structure of the liver (Ciza et al,2019).This increase could also be explained by free radical production which reacts with polyunsaturated fatty acids of cell membrane leading to impairment of mitochondrial and plasma membranes resulting in enzyme leakage. The result seemingly agrees with the reports of (Farombi and Onyema, 2006;Onyema et al 2012). In our work, biochemical assay demonstrated the changes in liver enzymes and products of oxidative stress.…”