Cortical thickness and surface area correlates with cognitive dysfunction among first-episode psychosis patients

Haring, Liina; Müürsepp, Andreas; Mõttus, René; Ilves, Pilvi; Koch, Kadri; Uppin, Kärt; Tarnovskaja, J.; Maron, Eduard; Zharkovsky, Alexander; Vasar, Eero; Vasar, Veiko

doi:10.1017/s0033291716000684

Cited by 15 publications

(10 citation statements)

References 74 publications

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“…Contrary to these results, others studies showed reduced cortical thickness in frontal regions in first-episode schizophrenia patients [31,32]. It is important to mention that cortical thickness has been related to cognitive dysfunction in FEP patients [33].…”

Section: Discussionmentioning

confidence: 76%

Long-Term Grey Matter Changes in First Episode Psychosis: A Systematic Review

Gallardo-Ruiz

Crespo‐Facorro

Setién-Suero

et al. 2019

Psychiatry Investig

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Objective To determine possible progressive changes of the grey matter at the first stages of the schizophrenia spectrum disorders, and to determine what regions are involved in these changes. Methods We searched the literature concerning studies on longitudinal changes in grey matter in first-episode psychosis using magnetic resonance imaging, especially studies with an interval between scans of more than a year. Only articles published before 2018 were searched. We selected 19 magnetic resonance imaging longitudinal studies that used different neuroimaging analysis techniques to study changes in cerebral grey matter in a group of patients with a first episode of psychosis. Results Patients with first episode of psychosis showed a decrease over time in cortical grey matter compared with a group of control subjects in frontal, temporal (specifically in superior regions), parietal, and subcortical regions. In addition to the above, studies indicate that patients showed a grey matter decrease in cerebellum and lateral ventricles volume. Conclusion The results suggest a decrease in grey matter in the years after the first episode of psychosis. Furthermore, the results of the studies showed consistency, regardless of the methods used in their analyses, as well as the time intervals between image collections.

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Section: Discussionmentioning

confidence: 76%

Long-Term Grey Matter Changes in First Episode Psychosis: A Systematic Review

Gallardo-Ruiz

Crespo‐Facorro

Setién-Suero

et al. 2019

Psychiatry Investig

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“…Correlations between general cognitive ability and GMV and CT were positive and consistent with studies of healthy individuals (25, 27, 36), whereas correlations between general cognitive ability and CSA were negative. Studies correlating CSA and cognition yield inconsistent results, with some showing positive correlations (25, 36, 70) and others showing negative (71) or no correlations between the two measures in healthy samples (72). The use of ICV as an adjustment variable may contribute to the negative relationship between general cognitive ability and CSA.…”

Section: Discussionmentioning

confidence: 99%

Multivariate Relationships Between Cognition and Brain Anatomy Across the Psychosis Spectrum

Rodrigue

McDowell

Tandon

et al. 2018

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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“…In FEP, volumetric decreases in thalamus, insula, and anterior cingulate have been consistently identified 38 . In addition, cortical thickness reductions have been reported, particularly across frontal regions [39][40][41][42][43][44] although some studies have also identified thinning in parietal and temporal regions including fusiform gyrus 39,42 . Regarding cortical thinning, the studies that have investigated this in FEP point to a fairly consistent pattern of thinning across frontal and parietal cortices 44 sometimes accompanied by thinning in temporal regions 42,45 .…”

Section: Brain Structural Correlates Of Functional Capacity In First-mentioning

confidence: 99%

Brain structural correlates of functional capacity in first-episode psychosis

Alkan

Davies

Greenwood

et al. 2020

Sci Rep

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Impaired functional capacity is a core feature of schizophrenia and presents even in first-episode psychosis (FEP) patients. Impairments in daily functioning tend to persist despite antipsychotic therapy but their neural basis is less clear. Previous studies suggest that volume loss in frontal cortex might be an important contributor, but findings are inconsistent. We aimed to comprehensively investigate the brain structural correlates of functional capacity in FEP using MRI and a reliable objective measure of functioning [University of California, San Diego Performance-Based Skills Assessment (UPSA)]. In a sample of FEP (n = 39) and a well-matched control group (n = 21), we measured cortical thickness, gray matter volume, and white matter tract integrity (fractional anisotropy, FA) within brain regions implicated by previous work. The FEP group had thinner cortex in various frontal regions and fusiform, and reduced FA in inferior longitudinal fasciculus (ILF). In FEP, poorer functional capacity correlated with reduced superior frontal volume and lower FA in left ILF. Importantly, frontal brain volumes and integrity of the ILF were identified as the structural correlates of functional capacity in FEP, controlling for other relevant factors. These findings enhance mechanistic understanding of functional capacity deficits in schizophrenia by specifying the underlying neural correlates. In future, this could help inform intervention strategies.

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Cortical thickness and surface area correlates with cognitive dysfunction among first-episode psychosis patients

Abstract: Significant correlations between CTh and CA with neurocognitive performance were localized in brain areas known to be involved in cognition. The results also suggested a disrupted structure-function relationship in FEP patients compared with CS.

Cited by 15 publications

References 74 publications

Long-Term Grey Matter Changes in First Episode Psychosis: A Systematic Review

Long-Term Grey Matter Changes in First Episode Psychosis: A Systematic Review

Multivariate Relationships Between Cognition and Brain Anatomy Across the Psychosis Spectrum

Brain structural correlates of functional capacity in first-episode psychosis

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