Brain structural correlates of functional capacity in first-episode psychosis

Alkan, Erkan; Davies, Geoff; Greenwood, Kathryn; Evans, Susan E.

doi:10.1038/s41598-020-73553-8

Cited by 5 publications

(2 citation statements)

References 82 publications

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“…Experts also believe that medication adherence is needed for adequate rehabilitation. This is in line with the finding that compliance with medication helps to improve symptoms, although it has little impact on recovery and functioning (Alkan et al, 2020 ; Chien & Yip, 2013 ; Millan et al, 2016 ; Swartz et al, 2007 ). Besides prolonged treatment, psychoeducation and personal understanding of recovery is needed to reach the rehabilitation goals in all areas of functioning.…”

Section: Discussionsupporting

confidence: 82%

Triangulation study of needs assessment of people with severe mental illness in “follow‐up” day hospital settings

2022

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Aim The aim of research was to assess the needs of patients with severe mental illness (SMI) attending follow‐up day hospital (DH) programmes from the patients', relatives' and experts' perspective. Design This triangulation research relies on three sources of information and two techniques of data collection. Methods Qualitative research was conducted comprising semi‐structured interviews (n = 15) and focus groups (n = 4) in three sequential rounds, triangulating patients', relatives' and experts' views. A content analysis was carried out. Results Study reveals a diverse spectrum of needs of SMI patients in follow‐up DH programmes. The analysis yielded six themes: optimal daily functioning, work and educational activities, social network inclusion, continuous treatment, support and guidance, long‐term care. DH programmes should assess the needs of patients with SMI and be adapted according to the findings. In addition to clinical treatment, requirements for continuous treatment, psychological and social needs, therapeutic relationship in less‐restrictive settings should be considered.

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Section: Discussionsupporting

confidence: 82%

Triangulation study of needs assessment of people with severe mental illness in “follow‐up” day hospital settings

2022

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“…Reduced cortical thickness has been consistently demonstrated in SZH 17 , including first episode psychosis 18 . The meta-analysis by van Erp et al 17 , found evidence for widespread cortical thinning; effect sizes were largest in frontal and temporal regions.…”

Section: Introductionmentioning

confidence: 95%

Cognitive impairment in schizophrenia: relationships with cortical thickness in fronto-temporal regions, and dissociability from symptom severity

2021

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Cognitive impairments are a core and persistent characteristic of schizophrenia with implications for daily functioning. These show only limited response to antipsychotic treatment and their neural basis is not well characterised. Previous studies point to relationships between cortical thickness and cognitive performance in fronto-temporal brain regions in schizophrenia patients (SZH). There is also evidence that these relationships might be independent of symptom severity, suggesting dissociable disease processes. We set out to explore these possibilities in a sample of 70 SZH and 72 age and gender-matched healthy controls (provided by the Center of Biomedical Research Excellence (COBRE)). Cortical thickness within fronto-temporal regions implicated by previous work was considered in relation to performance across various cognitive domains (from the MATRICS Cognitive Battery). Compared to controls, SZH had thinner cortices across most fronto-temporal regions and significantly lower performance on all cognitive domains. Robust relationships with cortical thickness were found: visual learning and attention performance correlated with bilateral superior and middle frontal thickness in SZH only. Correlations between attention performance and right transverse temporal thickness were also specific to SZH. Findings point to the importance of these regions for cognitive performance in SZH, possibly reflecting compensatory processes and/or aberrant connectivity. No links to symptom severity were observed in these regions, suggesting these relationships are dissociable from underlying psychotic symptomology. Findings enhance understanding of the brain structural underpinnings and possible aetiology of cognitive impairment in SZH.

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Associations between BMI and brain structures involved in food intake regulation in first-episode schizophrenia spectrum disorders and healthy controls

Luckhoff

Asmal²,

Scheffler³

et al. 2022

Journal of Psychiatric Research

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Brain structural correlates of functional capacity in first-episode psychosis

Cited by 5 publications

References 82 publications

Triangulation study of needs assessment of people with severe mental illness in “follow‐up” day hospital settings

Triangulation study of needs assessment of people with severe mental illness in “follow‐up” day hospital settings

Cognitive impairment in schizophrenia: relationships with cortical thickness in fronto-temporal regions, and dissociability from symptom severity

Associations between BMI and brain structures involved in food intake regulation in first-episode schizophrenia spectrum disorders and healthy controls

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